Search Results - "Giethlen, Bruno"

Discovery, Structure–Activity Relationship, and Antiparkinsonian Effect of a Potent and Brain-Penetrant Chemical Series of Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4 by Charvin, Delphine, Pomel, Vincent, Ortiz, Millan, Frauli, Mélanie, Scheffler, Sophie, Steinberg, Edith, Baron, Luc, Deshons, Laurène, Rudigier, Rachel, Thiarc, Delphine, Morice, Christophe, Manteau, Baptiste, Mayer, Stanislas, Graham, Danielle, Giethlen, Bruno, Brugger, Nadia, Hédou, Gaël, Conquet, François, Schann, Stephan

“…The metabotropic glutamate receptor 4 (mGluR4) is an emerging target for the treatment of Parkinson’s disease (PD). However, since the discovery of its…”
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Discovery of BNC375, a Potent, Selective, and Orally Available Type I Positive Allosteric Modulator of α7 nAChRs by Harvey, Andrew J, Avery, Thomas D, Schaeffer, Laurent, Joseph, Christophe, Huff, Belinda C, Singh, Rajinder, Morice, Christophe, Giethlen, Bruno, Grishin, Anton A, Coles, Carolyn J, Kolesik, Peter, Wagner, Stéphanie, Andriambeloson, Emile, Huyard, Bertrand, Poiraud, Etienne, Paul, Dharam, O’Connor, Susan M

“…Positive allosteric modulators (PAMs) of α7 nAChRs can have different properties with respect to their effects on channel kinetics. Type I PAMs amplify peak…”
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Lu AE58054, a 5-HT6 antagonist, reverses cognitive impairment induced by subchronic phencyclidine in a novel object recognition test in rats by Arnt, Jorn, Bang-Andersen, Benny, Grayson, Ben, Bymaster, Franklin P., Cohen, Michael P., DeLapp, Neil W., Giethlen, Bruno, Kreilgaard, Mads, McKinzie, David L., Neill, Joanna C., Nelson, David L., Nielsen, Søren M., Poulsen, Mette N., Schaus, John M., Witten, Louise M.

“…The in-vitro potency and selectivity, in-vivo binding affinity and effect of the 5-HT6R antagonist Lu AE58054…”
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Expeditious Route Towards (±)-Desethyleburnamonine, a Precursor of (±)-Vindeburnol by Jung-Deyon, Laurence, Giethlen, Bruno, Mann, André

“…An expeditious route to (±)‐desethyleburnamonine (1), a direct precursor of vindeburnol, is reported. Microwave irradiation of an indolo‐tetrahydropyridine…”
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LU AE58054, A POTENT AND SELECTIVE 5-HT6 ANTAGONIST, REVERSES SUBCHRONIC PCP-INDUCED COGNITIVE IMPAIRMENT IN A RAT NOVEL OBJECT RECOGNITION TEST by Arnt, Jørn, Bang-Andersen, Benny, Bymaster, Frank, Cohen, Michael, DeLapp, Neil, Giethlen, Bruno, Grayson, Ben, Kreilgaard, Mads, McKinzie, David, Neill, Jo, Nielsen, Søren M, Nelson, David, Poulsen, Mette N, Schaus, John, Witten, Louise M

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Oxidation of indolines with Fremy's salt: A mechanistic proposal by Giethlen, Bruno, Schaus, John M.

“…Oxidation of an indoline with Fremy's salt (potassium nitrosodisulfonate) led to the formation of an unstable intermediate which isomerized to the desired…”
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