Search Results - "Giese, Karl Peter"

The Roles of Protein Kinases in Learning and Memory by Giese, Karl Peter, Mizuno, Keiko

“…In the adult mammalian brain, more than 250 protein kinases are expressed, but only a few of these kinases are currently known to enable learning and memory…”
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Hippocampus-Dependent Memory Formation: Do Memory Type-Specific Mechanisms Exist? by Mizuno, Keiko, Giese, Karl Peter

“…Long-term memory (LTM) formation requires gene transcription and de novo protein synthesis. The transcription factor CREB is required for hippocampus-dependent…”
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GSK‐3: A key player in neurodegeneration and memory by Giese, Karl Peter

“…Abnormalities in molecular signalling have been implicated in neurodegeneration. It is emerging that glycogen synthase kinase‐3 (GSK‐3) is a key signalling…”
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Calcium/calmodulin‐dependent kinase II and memory destabilization: a new role in memory maintenance by Vigil, Fabio Antonio, Giese, Karl Peter

“…In this review, we discuss the poorly explored role of calcium/calmodulin‐dependent protein kinase II (CaMKII) in memory maintenance, and its influence on…”
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Prevention of long-term memory loss after retrieval by an endogenous CaMKII inhibitor by Vigil, Fabio Antonio, Mizuno, Keiko, Lucchesi, Walter, Valls-Comamala, Victoria, Giese, Karl Peter

“…CaMK2N1 and CaMK2N2 are endogenous inhibitors of calcium/calmodulin-dependent protein kinase II (CaMKII), a key synaptic signaling molecule for learning and…”
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Glycogen synthase kinase-3 inhibition is integral to long-term potentiation by Hooper, Claudie, Markevich, Vladimir, Plattner, Florian, Killick, Richard, Schofield, Emma, Engel, Tobias, Hernandez, Felix, Anderton, Brian, Rosenblum, Kobi, Bliss, Tim, Cooke, Sam F., Avila, Jesús, Lucas, José J., Giese, Karl Peter, Stephenson, John, Lovestone, Simon

“…Glycogen synthase kinase‐3 (GSK‐3) is a serine/threonine kinase regulating diverse cellular functions including metabolism, transcription and cell survival…”
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Effects of p35 Mutations Associated with Mental Retardation on the Cellular Function of p35-CDK5 by Takada, Shunsuke, Mizuno, Keiko, Saito, Taro, Asada, Akiko, Giese, Karl Peter, Hisanaga, Shin-Ichi

“…p35 is an activation subunit of the cyclin-dependent kinase 5 (CDK5), which is a Ser/Thr kinase that is expressed predominantly in neurons. Disruption of the…”
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Transcriptional corepressor SIN3A regulates hippocampal synaptic plasticity via Homer1/mGluR5 signaling by Bridi, Morgan, Schoch, Hannah, Florian, Cédrick, Poplawski, Shane G, Banerjee, Anamika, Hawk, Joshua D, Porcari, Giulia S, Lejards, Camille, Hahn, Chang-Gyu, Giese, Karl-Peter, Havekes, Robbert, Spruston, Nelson, Abel, Ted

“…Long-term memory depends on the control of activity-dependent neuronal gene expression, which is regulated by epigenetic modifications. The epigenetic…”
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In memoriam: John Lisman - commentaries on CaMKII as a memory molecule by Bear, Mark F, Cooke, Sam F, Giese, Karl Peter, Kaang, Bong-Kiun, Kennedy, Mary B, Kim, Ji-Il, Morris, Richard G M, Park, Pojeong

“…Shortly before he died in October 2017, John Lisman submitted an invited review to Molecular Brain on 'Criteria for identifying the molecular basis of the…”
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Insulin Receptor Substrate 2 Is a Negative Regulator of Memory Formation by Irvine, Elaine E, Drinkwater, Laura, Radwanska, Kasia, Al-Qassab, Hind, Smith, Mark A, O'Brien, Melissa, Kielar, Catherine, Choudhury, Agharul I, Krauss, Stefan, Cooper, Jonathan D, Withers, Dominic J, Giese, Karl Peter

“…Insulin has been shown to impact on learning and memory in both humans and animals, but the downstream signaling mechanisms involved are poorly characterized…”
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Cyclin-Dependent Kinase 5 Activator p25 Is Generated During Memory Formation and Is Reduced at an Early Stage in Alzheimer's Disease by Engmann, Olivia, Hortobágyi, Tibor, Thompson, Andrew J, Guadagno, Jennifer, Troakes, Claire, Soriano, Salvador, Al-Sarraj, Safa, Kim, Yong, Giese, Karl Peter

“…Background The cyclin-dependent kinase 5 activator p35 can be cleaved into p25. Formation of p25 has been suggested to contribute to neurodegeneration in…”
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Inhibitory Autophosphorylation of CaMKII Controls PSD Association, Plasticity, and Learning by Elgersma, Ype, Fedorov, Nikolai B, Ikonen, Sami, Choi, Esther S, Elgersma, Minetta, Carvalho, Ofelia M, Giese, Karl Peter, Silva, Alcino J

“…To investigate the function of the α calcium-calmodulin-dependent kinase II (αCaMKII) inhibitory autophosphorylation at threonines 305 and/or 306, we generated…”
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The role of CaMKII autophosphorylation for NMDA receptor-dependent synaptic potentiation by Giese, Karl Peter

“…Potentiation of glutamatergic synaptic transmission is thought to underlie memory. The induction of this synaptic potentiation relies on activation of NMDA…”
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Calcium/calmodulin-dependent kinase II and Alzheimer's disease by Ghosh, Anshua, Giese, Karl Peter

“…CaMKII is a remarkably complex protein kinase, known to have a fundamental role in synaptic plasticity and memory formation. Further, CaMKII has also been…”
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Hippocampus-dependent learning and memory is impaired in mice lacking the Ras-guanine-nucleotide releasing factor 1 (Ras-GRF1) by Giese, Karl Peter, Friedman, Eugenia, Telliez, Jean-Baptiste, Fedorov, Nikolai B, Wines, Mary, Feig, Larry A, Silva, Alcino J

“…Previous results have suggested that the Ras signaling pathway is involved in learning and memory. Ras is activated by nucleotide exchange factors, such as the…”
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A revised view of the role of CaMKII in learning and memory by Bayer, Karl Ulrich, Giese, Karl Peter

“…The Ca2+/calmodulin (CaM)-dependent protein kinase II (CaMKII) plays a fundamental role in learning and possibly also in memory. However, current mechanistic…”
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Novel Insights into the Beneficial and Detrimental Actions of Cdk5 by Giese, Karl Peter

“…In the adult brain, cyclin-dependent kinase 5 (Cdk5) can be beneficial by contributing to memory formation or can be detrimental by causing neurodegeneration,…”
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Novel insights into CaMKII function and regulation during memory formation by Lucchesi, Walter, Mizuno, Keiko, Giese, Karl Peter

“…Abstract Ca2+ /calmodulin-dependent kinase II (CaMKII) is an abundant synaptic signalling molecule that is essential for memory formation and the induction of…”
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Remembering Mike Stewart by Rusakov, Dmitri A., Giese, Karl Peter, Sandi, Carmen, Dommett, Eleanore, Overton, Paul G.

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Mice lacking the cAMP effector protein POPDC1 show enhanced hippocampal synaptic plasticity by Shetty, Mahesh Shivarama, Ris, Laurence, Schindler, Roland F R, Mizuno, Keiko, Fedele, Laura, Giese, Karl Peter, Brand, Thomas, Abel, Ted

“…Abstract Extensive research has uncovered diverse forms of synaptic plasticity and an array of molecular signaling mechanisms that act as positive or negative…”
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