Search Results - "Gierke, Sarah"

CLASPs link focal-adhesion-associated microtubule capture to localized exocytosis and adhesion site turnover by Stehbens, Samantha J., Paszek, Matthew, Pemble, Hayley, Ettinger, Andreas, Gierke, Sarah, Wittmann, Torsten

“…Turnover of integrin-based focal adhesions (FAs) with the extracellular matrix (ECM) is essential for coordinated cell movement. In collectively migrating…”
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Efbalropendekin Alfa enhances human natural killer cell cytotoxicity against tumor cell lines in vitro by Shehata, Hesham M, Dogra, Pranay, Gierke, Sarah, Holder, Patrick, Sanjabi, Shomyseh

“…IL-15 has shown preclinical activity by enhancing the functional maturation of natural killer (NK) cells. Clinical evaluation of the potential anticancer…”
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The Gag protein PEG10 binds to RNA and regulates trophoblast stem cell lineage specification by Abed, Mona, Verschueren, Erik, Budayeva, Hanna, Liu, Peter, Kirkpatrick, Donald S, Reja, Rohit, Kummerfeld, Sarah K, Webster, Joshua D, Gierke, Sarah, Reichelt, Mike, Anderson, Keith R, Newman, Robert J, Roose-Girma, Merone, Modrusan, Zora, Pektas, Hazal, Maltepe, Emin, Newton, Kim, Dixit, Vishva M

“…Peg10 (paternally expressed gene 10) is an imprinted gene that is essential for placental development. It is thought to derive from a Ty3-gyspy LTR (long…”
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Mechanism of Actin Network Attachment to Moving Membranes: Barbed End Capture by N-WASP WH2 Domains by Co, Carl, Wong, Derek T., Gierke, Sarah, Chang, Vicky, Taunton, Jack

“…Actin filament networks exert protrusive and attachment forces on membranes and thereby drive membrane deformation and movement. Here, we show that N-WASP WH2…”
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Tumor-intrinsic expression of the autophagy gene Atg16l1 suppresses anti-tumor immunity in colorectal cancer by Taraborrelli, Lucia, Şenbabaoğlu, Yasin, Wang, Lifen, Lim, Junghyun, Blake, Kerrigan, Kljavin, Noelyn, Gierke, Sarah, Scherl, Alexis, Ziai, James, McNamara, Erin, Owyong, Mark, Rao, Shilpa, Calviello, Aslihan Karabacak, Oreper, Daniel, Jhunjhunwala, Suchit, Argiles, Guillem, Bendell, Johanna, Kim, Tae Won, Ciardiello, Fortunato, Wongchenko, Matthew J., de Sauvage, Frederic J., de Sousa e Melo, Felipe, Yan, Yibing, West, Nathaniel R., Murthy, Aditya

“…Microsatellite-stable colorectal cancer (MSS-CRC) is highly refractory to immunotherapy. Understanding tumor-intrinsic determinants of immunotherapy resistance…”
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The neutrophil protein CD177 is a novel PDPN receptor that regulates human cancer-associated fibroblast physiology by Astarita, Jillian L, Keerthivasan, Shilpa, Husain, Bushra, Şenbabaoğlu, Yasin, Verschueren, Erik, Gierke, Sarah, Pham, Victoria C, Peterson, Sean M, Chalouni, Cecile, Pierce, Andrew A, Lill, Jennie R, Gonzalez, Lino C, Martinez-Martin, Nadia, Turley, Shannon J

“…The cancer-associated fibroblast (CAF) marker podoplanin (PDPN) is generally correlated with poor clinical outcomes in cancer patients and thus represents a…”
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Analysis of Microtubule Polymerization Dynamics in Live Cells by Gierke, Sarah, Kumar, Praveen, Wittmann, Torsten

“…The spatiotemporal regulation of intracellular microtubule polymerization dynamics, by numerous microtubule-associated proteins and other mechanisms, is…”
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Obligate role for Rock1 and Rock2 in adult stem cell viability and function by Sambandam, Arivazhagan, Storm, Elaine, Tauc, Helen, Hackney, Jason A., Garfield, David, Caplazi, Patrick, Liu, John, Zhang, Juan, Zhang, Hua, Duggan, Jeff, Jeet, Surinder, Gierke, Sarah, Chang, Patrick, Wu, Xiumin, Newman, Robert, Tam, Lucinda, Alcantar, Tuija, Wang, Lifen, Roose-Girma, Meron, Modrusan, Zora, Lee, Wyne P., Jasper, Heinrich, de Sauvage, Frederic, Pappu, Rajita

“…The ability of stem cells to rapidly proliferate and differentiate is integral to the steady-state maintenance of tissues with high turnover such as the blood…”
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EB1-Recruited Microtubule +TIP Complexes Coordinate Protrusion Dynamics during 3D Epithelial Remodeling by Gierke, Sarah, Wittmann, Torsten

“…Epithelial remodeling, in which apical-basal polarized cells switch to a migratory phenotype, plays a central role in development and disease of multicellular…”
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Single-Cell RNA Sequencing Reveals Stromal Evolution into LRRC15 + Myofibroblasts as a Determinant of Patient Response to Cancer Immunotherapy by Dominguez, Claudia X, Müller, Sören, Keerthivasan, Shilpa, Koeppen, Hartmut, Hung, Jeffrey, Gierke, Sarah, Breart, Beatrice, Foreman, Oded, Bainbridge, Travis W, Castiglioni, Alessandra, Senbabaoglu, Yasin, Modrusan, Zora, Liang, Yuxin, Junttila, Melissa R, Klijn, Christiaan, Bourgon, Richard, Turley, Shannon J

“…With only a fraction of patients responding to cancer immunotherapy, a better understanding of the entire tumor microenvironment is needed. Using single-cell…”
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Palmitoylation of TEAD Transcription Factors Is Required for Their Stability and Function in Hippo Pathway Signaling by Noland, Cameron L., Gierke, Sarah, Schnier, Paul D., Murray, Jeremy, Sandoval, Wendy N., Sagolla, Meredith, Dey, Anwesha, Hannoush, Rami N., Fairbrother, Wayne J., Cunningham, Christian N.

“…The Hippo signaling pathway is responsible for regulating the function of TEAD family transcription factors in metazoans. TEADs, with their co-activators…”
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GSK3β phosphorylation modulates CLASP-microtubule association and lamella microtubule attachment by Kumar, Praveen, Lyle, Karen S, Gierke, Sarah, Matov, Alexandre, Danuser, Gaudenz, Wittmann, Torsten

“…Polarity of the microtubule (MT) cytoskeleton is essential for many cell functions. Cytoplasmic linker-associated proteins (CLASPs) are MT-associated proteins…”
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Inhibition of MRTF activation as a clinically achievable anti-fibrotic mechanism for pirfenidone by Ma, Hsiao-Yen, Vander Heiden, Jason A, Uttarwar, Salil, Xi, Ying, N'Diaye, Elsa-Noah, LaCanna, Ryan, Caplazi, Patrick, Gierke, Sarah, Moffat, John, Wolters, Paul J, Ding, Ning

“…Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic disease characterised by aberrant fibroblast/myofibroblast accumulation and excessive collagen…”
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Effects of PI3K Inhibition on Afucosylated Antibody-Driven FcγRIIIa Events and Phospho-S6 Activity in NK Cells by Romeo, Valentina, Gierke, Sarah, Edgar, Kyle A, Liu, Scot D

“…PI3K is one of the most frequently mutated genes in cancers and has been the target of numerous anticancer therapies. With the additional development of…”
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A WISP1 antibody inhibits MRTF signaling to prevent the progression of established liver fibrosis by Xi, Ying, LaCanna, Ryan, Ma, Hsiao-Yen, N’Diaye, Elsa-Noah, Gierke, Sarah, Caplazi, Patrick, Sagolla, Meredith, Huang, Zhiyu, Lucio, Laura, Arlantico, Alexander, Jeet, Surinder, Brightbill, Hans, Emson, Claire, Wong, Aaron, Morshead, Katrina B., DePianto, Daryle J., Roose-Girma, Merone, Yu, Charles, Tam, Lucinda, Jia, Guiquan, Ramalingam, Thirumalai R., Marsters, Scot, Ashkenazi, Avi, Kim, Si Hyun, Kelly, Ryan, Wu, Shuang, Wolters, Paul J., Feldstein, Ariel E., Vander Heiden, Jason A., Ding, Ning

“…Fibrosis is the major risk factor associated with morbidity and mortality in patients with non-alcoholic steatohepatitis (NASH)-driven chronic liver disease…”
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Oncostatin M expression induced by bacterial triggers drives airway inflammatory and mucus secretion in severe asthma by Headland, Sarah E, Dengler, Hart S, Xu, Daqi, Teng, Grace, Everett, Christine, Ratsimandresy, Rojo A, Yan, Donghong, Kang, Jing, Ganeshan, Kirthana, Nazarova, Evgeniya V, Gierke, Sarah, Wedeles, Christopher J, Guidi, Riccardo, DePianto, Daryle J, Morshead, Katrina B, Huynh, Alison, Mills, Jessica, Flanagan, Sean, Hambro, Shannon, Nunez, Victor, Klementowicz, Joanna E, Shi, Yongchang, Wang, Jianyong, Bevers, 3rd, Jack, Ramirez-Carrozzi, Vladimir, Pappu, Rajita, Abbas, Alex, Vander Heiden, Jason, Choy, David F, Yadav, Rajbharan, Modrusan, Zora, Panettieri, Jr, Reynold A, Koziol-White, Cynthia, Jester, Jr, William F, Jenkins, Brendan J, Cao, Yi, Clarke, Christine, Austin, Cary, Lafkas, Daniel, Xu, Min, Wolters, Paul J, Arron, Joseph R, West, Nathaniel R, Wilson, Mark S

“…Exacerbations of symptoms represent an unmet need for people with asthma. Bacterial dysbiosis and opportunistic bacterial infections have been observed in, and…”
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Toxigenic Clostridium perfringens isolated from at-risk pediatric inflammatory bowel disease patients by Kuo, James, Uzunovic, Jasmina, Jacobson, Amanda, Dourado, Michelle, Gierke, Sarah, Rajendram, Manohary, Keilberg, Daniela, Mar, Jordan, Stekol, Emily, Curry, Joanna, Verstraete, Sofia, Lund, Jessica, Liang, Yuxin, Tamburini, Fiona B, Omattage, Natalie S, Masureel, Matthieu, Rutherford, Steven T, Hackos, David H, Tan, Man-Wah, Byrd, Allyson L, Keir, Mary E, Skippington, Elizabeth, Storek, Kelly M

“…The goal was to identify microbial drivers of IBD, by investigating mucosal-associated bacteria and their detrimental products in IBD patients. We directly…”
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Small molecule inhibition of group I p21-activated kinases in breast cancer induces apoptosis and potentiates the activity of microtubule stabilizing agents by Ong, Christy C, Gierke, Sarah, Pitt, Cameron, Sagolla, Meredith, Cheng, Christine K, Zhou, Wei, Jubb, Adrian M, Strickland, Laura, Schmidt, Maike, Duron, Sergio G, Campbell, David A, Zheng, Wei, Dehdashti, Seameen, Shen, Min, Yang, Nora, Behnke, Mark L, Huang, Wenwei, McKew, John C, Chernoff, Jonathan, Forrest, William F, Haverty, Peter M, Chin, Suet-Feung, Rakha, Emad A, Green, Andrew R, Ellis, Ian O, Caldas, Carlos, O'Brien, Thomas, Friedman, Lori S, Koeppen, Hartmut, Rudolph, Joachim, Hoeflich, Klaus P

“…Breast cancer, the most common cause of cancer-related deaths worldwide among women, is a molecularly and clinically heterogeneous disease. Extensive genetic…”
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A fluorescent splice-switching mouse model enables high-throughput, sensitive quantification of antisense oligonucleotide delivery and activity by Byrnes, Amy E., Roudnicky, Filip, Gogineni, Alvin, Soung, Allison L., Xiong, Monica, Hayne, Margaret, Heaster-Ford, Tiffany, Shatz-Binder, Whitney, Dominguez, Sara L., Imperio, Jose, Gierke, Sarah, Roberts, Jasmine, Guo, Jinglong, Ghosh, Soumitra, Yu, Charles, Roose-Girma, Merone, Elstrott, Justin, Easton, Amy, Hoogenraad, Casper C.

“…While antisense oligonucleotides (ASOs) are used in the clinic, therapeutic development is hindered by the inability to assay ASO delivery and activity…”
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The neutrophil protein CD177 is a novel PDPN receptor that regulates human cancer-associated fibroblast physiology by Jillian L. Astarita, Shilpa Keerthivasan, Bushra Husain, Yasin Şenbabaoğlu, Erik Verschueren, Sarah Gierke, Victoria C. Pham, Sean M. Peterson, Cecile Chalouni, Andrew A. Pierce, Jennie R. Lill, Lino C. Gonzalez, Nadia Martinez-Martin, Shannon J. Turley

“…The cancer-associated fibroblast (CAF) marker podoplanin (PDPN) is generally correlated with poor clinical outcomes in cancer patients and thus represents a…”
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