Search Results - "Gieras, Anna"

Epsin and Sla2 form assemblies through phospholipid interfaces by Garcia-Alai, Maria M., Heidemann, Johannes, Skruzny, Michal, Gieras, Anna, Mertens, Haydyn D. T., Svergun, Dmitri I., Kaksonen, Marko, Uetrecht, Charlotte, Meijers, Rob

“…In clathrin-mediated endocytosis, adapter proteins assemble together with clathrin through interactions with specific lipids on the plasma membrane. However,…”
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An Organized Co-assembly of Clathrin Adaptors Is Essential for Endocytosis by Skruzny, Michal, Desfosses, Ambroise, Prinz, Simone, Dodonova, Svetlana O., Gieras, Anna, Uetrecht, Charlotte, Jakobi, Arjen J., Abella, Marc, Hagen, Wim J.H., Schulz, Joachim, Meijers, Rob, Rybin, Vladimir, Briggs, John A.G., Sachse, Carsten, Kaksonen, Marko

“…Clathrin-mediated endocytosis, the main trafficking route from the plasma membrane to the cytoplasm, is critical to many fundamental cellular processes…”
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Immune System Remodelling by Prenatal Betamethasone: Effects on β-Cells and Type 1 Diabetes by Perna-Barrull, David, Gieras, Anna, Rodriguez-Fernandez, Silvia, Tolosa, Eva, Vives-Pi, Marta

“…Type 1 diabetes (T1D) is a multifactorial disease of unknown aetiology. Studies focusing on environment-related prenatal changes, which might have an influence…”
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Prediction of IgE-binding epitopes by means of allergen surface comparison and correlation to cross-reactivity by Dall'Antonia, Fabio, PhD, Gieras, Anna, PhD, Devanaboyina, Siva Charan, PhD, Valenta, Rudolf, MD, Keller, Walter, PhD

“…Background The experimental determination of conformational allergen epitopes recognized by IgE is a difficult task because they often involve discontinuous…”
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Prenatal Administration of Betamethasone Causes Changes in the T Cell Receptor Repertoire Influencing Development of Autoimmunity by Gieras, Anna, Gehbauer, Christina, Perna-Barrull, David, Engler, Jan Broder, Diepenbruck, Ines, Glau, Laura, Joosse, Simon A, Kersten, Nora, Klinge, Stefanie, Mittrücker, Hans-Willi, Friese, Manuel A, Vives-Pi, Marta, Tolosa, Eva

“…Prenatal glucocorticoids are routinely administered to pregnant women at risk of preterm delivery in order to improve survival of the newborn. However, in half…”
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Hypoallergenic derivatives of the major birch pollen allergen Bet v 1 obtained by rational sequence reassembly by Campana, Raffaela, PhD, Vrtala, Susanne, PhD, Maderegger, Bernhard, PhD, Jertschin, Peter, PhD, Stegfellner, Gottfried, PhD, Swoboda, Ines, PhD, Focke-Tejkl, Margarete, PhD, Blatt, Katharina, Gieras, Anna, MSc, Zafred, Domen, BSc, Neubauer, Angela, PhD, Valent, Peter, MD, Keller, Walter, PhD, Spitzauer, Susanne, MD, Valenta, Rudolf, MD

“…Background At least 100 million patients suffer from birch pollen allergy. Objective Rational design of recombinant derivatives of the major birch pollen…”
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Fatal COVID-19 in a Child with Persistence of SARS-CoV-2 Despite Extensive Multidisciplinary Treatment: A Case Report by Apostolidou, Sofia, Harbauer, Theresa, Lasch, Peter, Biermann, Daniel, Hempel, Maja, Lütgehetmann, Marc, Pfefferle, Susanne, Herrmann, Jochen, Rüffer, André, Reinshagen, Konrad, Kozlik-Feldmann, Rainer, Gieras, Anna, Kniep, Inga, Oh, Jun, Singer, Dominique, Ebenebe, Chinedu Ulrich, Kobbe, Robin

“…Critical Coronavirus disease 2019 (COVID-19) developed in a 7-year-old girl with a history of dystrophy, microcephaly, and central hypothyroidism. Starting…”
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IgE epitope proximity determines immune complex shape and effector cell activation capacity by Gieras, Anna, PhD, Linhart, Birgit, PhD, Roux, Kenneth H., PhD, Dutta, Moumita, PhD, Khodoun, Marat, PhD, Zafred, Domen, PhD, Cabauatan, Clarissa R., PhD, Lupinek, Christian, MD, Weber, Milena, MSc, Focke-Tejkl, Margarete, PhD, Keller, Walter, PhD, Finkelman, Fred D., MD, Valenta, Rudolf, MD

“…Background IgE-allergen complexes induce mast cell and basophil activation and thus immediate allergic inflammation. They are also important for…”
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Molecular determinants of allergen-induced effector cell degranulation by Gieras, Anna, MSc, Focke-Tejkl, Margarete, PhD, Ball, Tanja, PhD, Verdino, Petra, PhD, Hartl, Arnulf, PhD, Thalhamer, Josef, PhD, Valenta, Rudolf, MD

“…Background Allergen-induced effector cell degranulation is a key event in allergic inflammation and leads to early-phase symptoms, such as allergic rhinitis,…”
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Mast cell–derived proteases control allergic inflammation through cleavage of IgE by Rauter, Ingrid, PhD, Krauth, Maria-Theresa, MD, Westritschnig, Kerstin, MD, Horak, Friedrich, MD, Flicker, Sabine, PhD, Gieras, Anna, MSc, Repa, Andreas, MD, Balic, Nadja, Spitzauer, Susanne, MD, Huss-Marp, Johannes, MD, Brockow, Knut, MD, Darsow, Ulf, MD, Behrendt, Heidrun, MD, Ring, Johannes, MD, Kricek, Franz, PhD, Valent, Peter, MD, Valenta, Rudolf, MD

“…Background Cross-linking of mast cell–bound IgE releases proinflammatory mediators, cytokines, and proteolytic enzymes and is a key event in allergic…”
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Prenatal glucocorticoids: Consequences for the offspring's immunity by Tolosa, Eva, Gehbauer, Christina, Gieras, Anna, Diepenbruck, Ines

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Thymic Atrophy and Immune Dysregulation in Infants with Complex Congenital Heart Disease by Bremer, Sarah-Jolan, Boxnick, Annika, Glau, Laura, Biermann, Daniel, Joosse, Simon A., Thiele, Friederike, Billeb, Elena, May, Jonathan, Kolster, Manuela, Hackbusch, Romy, Fortmann, Mats Ingmar, Kozlik-Feldmann, Rainer, Hübler, Michael, Tolosa, Eva, Sachweh, Jörg Siegmar, Gieras, Anna

“…Congenital heart disease (CHD) is the most common birth defect, and up to 50% of infants with CHD require cardiovascular surgery early in life. Current…”
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Mapping of conformational IgE epitopes with peptide-specific monoclonal antibodies reveals simultaneous binding of different IgE antibodies to a surface patch on the major birch pollen allergen, Bet v 1 by Gieras, Anna, Cejka, Petra, Blatt, Katharina, Focke-Tejkl, Margarete, Linhart, Birgit, Flicker, Sabine, Stoecklinger, Angelika, Marth, Katharina, Drescher, Anja, Thalhamer, Josef, Valent, Peter, Majdic, Otto, Valenta, Rudolf

“…Allergic inflammation is based on the cross-linking of mast cell and basophil-bound IgE Abs and requires at least two binding sites for IgE on allergens, which…”
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A nonallergenic birch pollen allergy vaccine consisting of hepatitis PreS-fused Bet v 1 peptides focuses blocking IgG toward IgE epitopes and shifts immune responses to a tolerogenic and Th1 phenotype by Marth, Katharina, Breyer, Isabella, Focke-Tejkl, Margarete, Blatt, Katharina, Shamji, Mohamed H, Layhadi, Janice, Gieras, Anna, Swoboda, Ines, Zafred, Domen, Keller, Walter, Valent, Peter, Durham, Stephen R, Valenta, Rudolf

“…Allergen-specific immunotherapy is the only allergen-specific and disease-modifying treatment for allergy. The construction and characterization of a vaccine…”
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OMIP 073: Analysis of human thymocyte development with a 14‐color flow cytometry panel by Bremer, Sarah‐Jolan, Glau, Laura, Gehbauer, Christina, Boxnick, Annika, Biermann, Daniel, Sachweh, Jörg Siegmar, Tolosa, Eva, Gieras, Anna

“…This panel was designed for the identification and detailed characterization of the different developmental steps of human thymocytes. We optimized the panel…”
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Impact of Betamethasone Pretreatment on Engrafment of Cord Blood-Derived Hematopoietic Stem Cells by Perna-Barrull, David, Gomez-Muñoz, Laia, Rodriguez-Fernandez, Silvia, Gieras, Anna, Ampudia-Carrasco, Rosa M., Almenara-Fuentes, Lidia, Risueño, Ruth M., Querol, Sergi, Tolosa, Eva, Vives-Pi, Marta

“…Hematopoietic stem cell (HSC) transplantation is crucial to cure hematologic malignancies. Umbilical cord blood (UCB) is a source of stem cells, but 90% of UCB…”
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Prenatal Betamethasone interferes with immune system development and alters target cells in autoimmune diabetes by Perna-Barrull, David, Rodriguez-Fernandez, Silvia, Pujol-Autonell, Irma, Gieras, Anna, Ampudia-Carrasco, Rosa M., Villalba, Adrian, Glau, Laura, Tolosa, Eva, Vives-Pi, Marta

“…Non-genetic factors are crucial in the pathogenesis of type 1 diabetes (T1D), a disease caused by autoimmunity against insulin-producing β-cells. Exposure to…”
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Altered IgE epitope presentation: A model for hypoallergenic activity revealed for Bet v 1 trimer by Campana, Raffaela, Vrtala, Susanne, Maderegger, Bernhard, Dall’Antonia, Yuliya, Zafred, Domen, Blatt, Katharina, Herrmann, Harald, Focke-Tejkl, Margarete, Swoboda, Ines, Scheiblhofer, Sandra, Gieras, Anna, Neubauer, Angela, Keller, Walter, Valent, Peter, Thalhamer, Josef, Spitzauer, Susanne, Valenta, Rudolf

“…In order to reduce side effects in the course of allergen specific immunotherapy hypoallergenic allergen derivatives with reduced IgE reactivity have been made…”
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Reduction of the in vivo allergenicity of Der p 2, the major house-dust mite allergen, by genetic engineering by Chen, Kuan-Wei, Fuchs, Gudrun, Sonneck, Karoline, Gieras, Anna, Swoboda, Ines, Douladiris, Nikolas, Linhart, Birgit, Jankovic, Marija, Pavkov, Tea, Keller, Walter, Papadopoulos, Nikolaos G., Valent, Peter, Valenta, Rudolf, Vrtala, Susanne

“…The major allergen of the house-dust mite Dermatophagoides pteronyssinus, Der p 2, is recognized by approximately 90% of mite-allergic patients. We have…”
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Allergen cleavage by effector cell-derived proteases regulates allergic inflammation by Rauter, Ingrid, Krauth, Maria-Theresa, Flicker, Sabine, Gieras, Anna, Westritschnig, Kerstin, Vrtala, Susanne, Balic, Nadja, Spitzauer, Susanne, Huss-Marp, Johannes, Brockow, Knut, Darsow, Ulf, Ring, Johannes, Behrendt, Heidrun, Semper, Hans, Valent, Peter, Valenta, Rudolf

“…The key event of allergic inflammation, allergen-induced crosslinking of mast cell-bound IgE antibodies, is accompanied by release of inflammatory mediators,…”
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