Botulinum Toxin Type a Induces Apoptosis in Nasal Glands of Guinea Pigs

Botulinum Toxin Type a Induces Apoptosis in Nasal Glands of Guinea Pigs

Nasal hypersecretion is predominantly caused by overaction of nasal glands, which are mainly under cholinergic control. In this work, we investigated the influence of botulinum toxin A (BTA) on the nasal mucosal tissue of the maxillary sinus turbinates of guinea pigs (n = 10) that were painlessly sa...

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Bibliographic Details
Published in:Annals of otology, rhinology & laryngology Vol. 110; no. 11; pp. 1045 - 1050
Main Authors: Rohrbach, Saskia, Olthoff, Arno, Giefer, Birgit, Laskawi, Rainer, Götz, Werner
Format: Journal Article
Language:English
Published: Los Angeles, CA SAGE Publications 01-11-2001
Annals Publishing Compagny
SAGE PUBLICATIONS, INC
Subjects:
Animals
Apoptosis - drug effects
Biological and medical sciences
Botulinum Toxins, Type A - pharmacology
Ent. Stomatology
Guinea Pigs
In Situ Nick-End Labeling
Medical sciences
Nasal Mucosa - drug effects
Nasal Mucosa - pathology
Nasal Mucosa - secretion
Neuromuscular Agents - pharmacology
Non tumoral diseases
Otorhinolaryngology. Stomatology
Periodic Acid-Schiff Reaction
Pharmacology. Drug treatments
Rhinitis - physiopathology
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
botulinum toxin
apoptosis
nasal glands
Nose disease
Enzyme
Induction
Rodentia
Metalloendopeptidases
Gland
Experimental study
Hypersecretion
Peptidases
Vertebrata
Bontoxilysin
Chemotherapy
Mammalia
Guinea pig
Treatment
Animal
Nose
Hydrolases
ENT disease
Biological effect
Apoptosis
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Summary:Nasal hypersecretion is predominantly caused by overaction of nasal glands, which are mainly under cholinergic control. In this work, we investigated the influence of botulinum toxin A (BTA) on the nasal mucosal tissue of the maxillary sinus turbinates of guinea pigs (n = 10) that were painlessly sacrificed 10 days (short-term group) or 3 months (long-term group) after local treatment with 20 units of BTA (Botox) or 0.2 mL of 0.9% sodium chloride (control). Histologic investigation of the nasal mucosal tissue of the BTA-treated animals (short-term group) showed degeneration of glands and ducts and apoptotic nuclei on TUNEL staining of these structures. The control animals revealed normal glandular tissue and no apoptosis. The animals of the long-term group showed almost normal glandular tissue and only a few apoptotic nuclei. In conclusion, BTA induces temporary apoptosis in the nasal glandular compartment of guinea pigs.
ISSN:0003-4894
1943-572X
DOI:10.1177/000348940111001110