Search Results - "Giedt, Randy"

Ultrafluorogenic Coumarin-Tetrazine Probes for Real-Time Biological Imaging by Meimetis, Labros G., Carlson, Jonathan C. T., Giedt, Randy J., Kohler, Rainer H., Weissleder, Ralph

“…We have developed a series of new ultrafluorogenic probes in the blue‐green region of the visible‐light spectrum that display fluorescence enhancement…”
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Single-cell barcode analysis provides a rapid readout of cellular signaling pathways in clinical specimens by Giedt, Randy J., Pathania, Divya, Carlson, Jonathan C. T., McFarland, Philip J., del Castillo, Andres Fernandez, Juric, Dejan, Weissleder, Ralph

“…Serial tissue sampling has become essential in guiding modern targeted and personalized cancer treatments. An alternative to image guided core biopsies are…”
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Red Si-rhodamine drug conjugates enable imaging in GFP cells by Kim, Eunha, Yang, Katherine S, Giedt, Randy J, Weissleder, Ralph

“…Here we evaluated a series of Si-derivatized rhodamine (SiR) dyes for their ability to visualize a model drug in live cells. We show that a charge neutral SiR…”
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Mitochondrial fission in endothelial cells after simulated ischemia/reperfusion: role of nitric oxide and reactive oxygen species by Giedt, Randy J., Yang, Changjun, Zweier, Jay L., Matzavinos, Anastasios, Alevriadou, B. Rita

“…Ischemia (I)/reperfusion (RP)-induced endothelial cell (EC) injury is thought to be due to mitochondrial reactive oxygen species (mtROS) production. MtROS have…”
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Imaging windows for long-term intravital imaging: General overview and technical insights by Alieva, Maria, Ritsma, Laila, Giedt, Randy J, Weissleder, Ralph, van Rheenen, Jacco

“…Intravital microscopy is increasingly used to visualize and quantitate dynamic biological processes at the (sub)cellular level in live animals. By visualizing…”
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Quantitating drug-target engagement in single cells in vitro and in vivo by Dubach, J Matthew, Kim, Eunha, Yang, Katherine, Cuccarese, Michael, Giedt, Randy J, Meimetis, Labros G, Vinegoni, Claudio, Weissleder, Ralph

“…The use of fluorescence-polarized microscopy, combined with competitive binding with matched fluorescence companion imaging probes, enable target engagement…”
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Computational imaging reveals mitochondrial morphology as a biomarker of cancer phenotype and drug response by Giedt, Randy J., Fumene Feruglio, Paolo, Pathania, Divya, Yang, Katherine S., Kilcoyne, Aoife, Vinegoni, Claudio, Mitchison, Timothy J., Weissleder, Ralph

“…Mitochondria, which are essential organelles in resting and replicating cells, can vary in number, mass and shape. Past research has primarily focused on…”
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Single cell analysis of drug distribution by intravital imaging by Giedt, Randy J, Koch, Peter D, Weissleder, Ralph

“…Recent advances in the field of intravital imaging have for the first time allowed us to conduct pharmacokinetic and pharmacodynamic studies at the single cell…”
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Single cell resolution in vivo imaging of DNA damage following PARP inhibition by Yang, Katherine S., Kohler, Rainer H., Landon, Matthieu, Giedt, Randy, Weissleder, Ralph

“…Targeting DNA repair pathways is a powerful strategy to treat cancers. To gauge efficacy in vivo , typical response markers include late stage effects such as…”
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Mitochondrial Dynamics and Motility Inside Living Vascular Endothelial Cells: Role of Bioenergetics by Giedt, Randy J., Pfeiffer, Douglas R., Matzavinos, Anastasios, Kao, Chiu-Yen, Alevriadou, B. Rita

“…The mitochondrial network is dynamic with conformations that vary between a tubular continuum and a fragmented state. The equilibrium between mitochondrial…”
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Fluorescent vinblastine probes for live cell imaging by Meimetis, Labros G, Giedt, Randy J, Mikula, Hannes, Carlson, Jonathan C, Kohler, Rainer H, Pirovich, David B, Weissleder, Ralph

“…Herein we describe the synthesis of several fluorescent analogues of the clinically approved microtubule destabilizing agent vinblastine. The evaluated probes…”
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Quantitating drug-target engagement in single cells in vitro and in vivo by Dubach, J Matthew, Kim, Eunha, Yang, Katherine, Cuccarese, Michael, Giedt, Randy J, Meimetis, Labros G, Vinegoni, Claudio, Weissleder, Ralph

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Mitochondria-derived reactive oxygen species mediate heme oxygenase-1 expression in sheared endothelial cells by Han, Zhaosheng, Varadharaj, Saradhadevi, Giedt, Randy J, Zweier, Jay L, Szeto, Hazel H, Alevriadou, B Rita

“…Bovine aortic endothelial cells (ECs) respond to nitric oxide (NO) donors by activating the redox-sensitive NF-E2-related factor 2/antioxidant response element…”
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Imaging Cellular Distribution of Bcl Inhibitors Using Small Molecule Drug Conjugates by Giedt, Randy J, Sprachman, Melissa M, Yang, Katherine S, Weissleder, Ralph

“…Overexpression of anti-apoptotic proteins such as Bcl-2 is a cellular mechanism to evade apoptosis; consequently, Bcl-2 inhibitors are being developed as…”
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On chip analysis of CNS lymphoma in cerebrospinal fluid by Turetsky, Anna, Lee, Kyungheon, Song, Jun, Giedt, Randy J, Kim, Eunha, Kovach, Alexandra E, Hochberg, Ephraim P, Castro, Cesar M, Lee, Hakho, Weissleder, Ralph

“…Molecular profiling of central nervous system lymphomas in cerebrospinal fluid (CSF) samples can be challenging due to the paucicellular and limited nature of…”
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Automated analysis of clonal cancer cells by intravital imaging by Coffey, Sarah Earley, Giedt, Randy J, Weissleder, Ralph

“…Longitudinal analyses of single cell lineages over prolonged periods have been challenging particularly in processes characterized by high cell turn-over such…”
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Ultrafluorogenic Coumarin-Tetrazine Probes for Real-Time Biological Imaging by Meimetis, Labros G., Carlson, Jonathan C. T., Giedt, Randy J., Kohler, Rainer H., Weissleder, Ralph

“…We have developed a series of new ultrafluorogenic probes in the blue‐green region of the visible‐light spectrum that display fluorescence enhancement…”
Get full text

Abstract 234: Mitochondrial morphology as a biomarker of cancer phenotype and drug response by Giedt, Randy J., Fumene Fergulio, Paolo, Pathania, Divya, Yang, Katherine S., Kilcoyne, Aoife, Vinegoni, Claudio, Mitchison, Tim J., Weissleder, Ralph

“…Mitochondria, critical organelles in quiescent and dividing cells, have been shown to vary in number, mass, and shape. While previous work has focused on…”
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Mitochondrial fission in endothelial cells following simulated ischemia/reperfusion: Role of nitric oxide and reactive oxygen species by Giedt, Randy J., Yang, Changjun, Zweier, Jay L., Matzavinos, Anastasios, Alevriadou, B. Rita

“…Ischemia (I)/reperfusion (RP)-induced endothelial cell (EC) injury is thought to occur due to mitochondrial reactive oxygen species (mtROS) production. MtROS…”
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Mitochondrial DNA damage in vascular endothelial cells exposed to shear stress by Galbraith, Valerie K, Giedt, Randy J, Panduri, Vijji, Van Houten, Bennett, Alevriadou, B Rita

“…Abstract only…”
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