Search Results - "Giddens, Don"

Coronary Artery Wall Shear Stress Is Associated With Progression and Transformation of Atherosclerotic Plaque and Arterial Remodeling in Patients With Coronary Artery Disease by SAMADY, Habib, ESHTEHARDI, Parham, MCDANIEL, Michael C, JIN SUO, DHAWAN, Saurabh S, MAYNARD, Charles, TIMMINS, Lucas H, QUYYUMI, Arshed A, GIDDENS, Don P

“…Experimental studies suggest that low wall shear stress (WSS) promotes plaque development and high WSS is associated with plaque destabilization. We…”
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High wall shear stress and high-risk plaque: an emerging concept by Eshtehardi, Parham, Brown, Adam J., Bhargava, Ankit, Costopoulos, Charis, Hung, Olivia Y., Corban, Michel T., Hosseini, Hossein, Gogas, Bill D., Giddens, Don P., Samady, Habib

“…In recent years, there has been a significant effort to identify high-risk plaques in vivo prior to acute events. While number of imaging modalities have been…”
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High Coronary Shear Stress in Patients With Coronary Artery Disease Predicts Myocardial Infarction by Kumar, Arnav, Thompson, Elizabeth W., Lefieux, Adrien, Molony, David S., Davis, Emily L., Chand, Nikita, Fournier, Stephane, Lee, Hee Su, Suh, Jon, Sato, Kimi, Ko, Yi-An, Molloy, Daniel, Chandran, Karthic, Hosseini, Hossein, Gupta, Sonu, Milkas, Anastasios, Gogas, Bill, Chang, Hyuk-Jae, Min, James K., Fearon, William F., Veneziani, Alessandro, Giddens, Don P., King, Spencer B., De Bruyne, Bernard, Samady, Habib

“…Coronary lesions with low fractional flow reserve (FFR) that are treated medically are associated with higher revascularization rates. High wall shear stress…”
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Partial carotid ligation is a model of acutely induced disturbed flow, leading to rapid endothelial dysfunction and atherosclerosis by Nam, Douglas, Ni, Chih-Wen, Rezvan, Amir, Suo, Jin, Budzyn, Klaudia, Llanos, Alexander, Harrison, David, Giddens, Don, Jo, Hanjoong

“…Atherosclerosis is closely associated with disturbed flow characterized by low and oscillatory shear stress, but studies directly linking disturbed flow to…”
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Computing Fractional Flow Reserve During Coronary Angiography: How Good Is Good Enough? by Giddens, Don P.

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Combination of plaque burden, wall shear stress, and plaque phenotype has incremental value for prediction of coronary atherosclerotic plaque progression and vulnerability by Corban, Michel T, Eshtehardi, Parham, Suo, Jin, McDaniel, Michael C, Timmins, Lucas H, Rassoul-Arzrumly, Emad, Maynard, Charles, Mekonnen, Girum, King, Spencer, Quyyumi, Arshed A, Giddens, Don P, Samady, Habib

“…Abstract Aims Large plaque burden, certain phenotypes, and low wall shear stress (WSS) are associated with adverse outcomes and high WSS with development of…”
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Oscillatory wall shear stress is a dominant flow characteristic affecting lesion progression patterns and plaque vulnerability in patients with coronary artery disease by Timmins, Lucas H., Molony, David S., Eshtehardi, Parham, McDaniel, Michael C., Oshinski, John N., Giddens, Don P., Samady, Habib

“…Although experimental studies suggest that low and oscillatory wall shear stress (WSS) promotes plaque transformation to a more vulnerable phenotype, this…”
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Mass transport of low density lipoprotein in reconstructed hemodynamic environments of human carotid arteries: the role of volume and solute flux through the endothelium by Kim, Sungho, Giddens, Don P

“…The accumulation of low density lipoprotein (LDL) in the arterial intima is a critical step in the initiation and progression of atheromatous lesions. In this…”
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Computing Fractional Flow Reserve During Coronary Angiography by Giddens, Don P., PhD

“…Corresponding Author Image 1…”
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Magnetic Targeting of Human Mesenchymal Stem Cells with Internalized Superparamagnetic Iron Oxide Nanoparticles by Landázuri, Natalia, Tong, Sheng, Suo, Jin, Joseph, Giji, Weiss, Daiana, Sutcliffe, Diane J., Giddens, Don P., Bao, Gang, Taylor, W. Robert

“…Cell therapies offer exciting new opportunities for effectively treating many human diseases. However, delivery of therapeutic cells by intravenous injection,…”
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Do-it-yourself in vitro vasculature that recapitulates in vivo geometries for investigating endothelial-blood cell interactions by Mannino, Robert G., Myers, David R., Ahn, Byungwook, Wang, Yichen, Margo Rollins, Gole, Hope, Lin, Angela S., Guldberg, Robert E., Giddens, Don P., Timmins, Lucas H., Lam, Wilbur A.

“…Investigating biophysical cellular interactions in the circulation currently requires choosing between in vivo models, which are difficult to interpret due in…”
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Image-based biomechanical modeling for coronary atherosclerotic plaque progression and vulnerability prediction by Lv, Rui, Wang, Liang, Maehara, Akiko, Guo, Xiaoya, Zheng, Jie, Samady, Habib, Giddens, Don P., Mintz, Gary S., Stone, Gregg W., Tang, Dalin

“…Atherosclerotic plaque progression and rupture play an important role in cardiovascular disease development and the final drastic events such as heart attack…”
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Low Coronary Wall Shear Stress Is Associated With Severe Endothelial Dysfunction in Patients With Nonobstructive Coronary Artery Disease by Kumar, Arnav, Hung, Olivia Y., Piccinelli, Marina, Eshtehardi, Parham, Corban, Michel T., Sternheim, David, Yang, Boyi, Lefieux, Adrien, Molony, David S., Thompson, Elizabeth W., Zeng, Wenjie, Bouchi, Yasir, Gupta, Sonu, Hosseini, Hossein, Raad, Mohamad, Ko, Yi-An, Liu, Chang, McDaniel, Michael C., Gogas, Bill D., Douglas, John S., Quyyumi, Arshed A., Giddens, Don P., Veneziani, Alessandro, Samady, Habib

“…This study investigated the relationship between low wall shear stress (WSS) and severe endothelial dysfunction (EDFx). Local hemodynamic forces such as WSS…”
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Hemodynamic Shear Stresses in Mouse Aortas: Implications for Atherogenesis by Suo, Jin, Ferrara, Dardo E, Sorescu, Dan, Guldberg, Robert E, Taylor, W Robert, Giddens, Don P

“…OBJECTIVE—The hemodynamic environment is a determinant of susceptibility to atherosclerosis in the vasculature. Although mouse models are commonly used in…”
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Using Optical Coherence Tomography and Intravascular Ultrasound Imaging to Quantify Coronary Plaque Cap Stress/Strain and Progression: A Follow-Up Study Using 3D Thin-Layer Models by Lv, Rui, Maehara, Akiko, Matsumura, Mitsuaki, Wang, Liang, Zhang, Caining, Huang, Mengde, Guo, Xiaoya, Samady, Habib, Giddens, Don. P., Zheng, Jie, Mintz, Gary S., Tang, Dalin

“…Accurate plaque cap thickness quantification and cap stress/strain calculations are of fundamental importance for vulnerable plaque research. To overcome…”
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Combining IVUS and Optical Coherence Tomography for More Accurate Coronary Cap Thickness Quantification and Stress/Strain Calculations: A Patient-Specific Three-Dimensional Fluid-Structure Interaction Modeling Approach by Guo, Xiaoya, Giddens, Don P, Molony, David, Yang, Chun, Samady, Habib, Zheng, Jie, Mintz, Gary S, Maehara, Akiko, Wang, Liang, Pei, Xuan, Li, Zhi-Yong, Tang, Dalin

“…Accurate cap thickness and stress/strain quantifications are of fundamental importance for vulnerable plaque research. Virtual histology intravascular…”
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Predicting plaque vulnerability change using intravascular ultrasound + optical coherence tomography image-based fluid-structure interaction models and machine learning methods with patient follow-up data: a feasibility study by Guo, Xiaoya, Maehara, Akiko, Matsumura, Mitsuaki, Wang, Liang, Zheng, Jie, Samady, Habib, Mintz, Gary S, Giddens, Don P, Tang, Dalin

“…Coronary plaque vulnerability prediction is difficult because plaque vulnerability is non-trivial to quantify, clinically available medical image modality is…”
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Using optical coherence tomography and intravascular ultrasound imaging to quantify coronary plaque cap thickness and vulnerability: a pilot study by Lv, Rui, Maehara, Akiko, Matsumura, Mitsuaki, Wang, Liang, Wang, Qingyu, Zhang, Caining, Guo, Xiaoya, Samady, Habib, Giddens, Don P, Zheng, Jie, Mintz, Gary S, Tang, Dalin

“…Abstract Background Detecting coronary vulnerable plaques in vivo and assessing their vulnerability have been great challenges for clinicians and the research…”
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Optical Coherence Tomography-Based Patient-Specific Residual Multi-Thrombus Coronary Plaque Models With Fluid-Structure Interaction for Better Treatment Decisions: A Biomechanical Modeling Case Study by Wang, Liang, He, Luping, Jia, Haibo, Lv, Rui, Guo, Xiaoya, Yang, Chun, Giddens, Don P, Samady, Habib, Maehara, Akiko, Mintz, Gary S, Yu, Bo, Tang, Dalin

“…Intracoronary thrombus from plaque erosion could cause fatal acute coronary syndrome (ACS). A conservative antithrombotic therapy has been proposed to treat…”
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Predicting Coronary Stenosis Progression Using Plaque Fatigue From IVUS-Based Thin-Slice Models: A Machine Learning Random Forest Approach by Guo, Xiaoya, Maehara, Akiko, Yang, Mingming, Wang, Liang, Zheng, Jie, Samady, Habib, Mintz, Gary S, Giddens, Don P, Tang, Dalin

“…Coronary stenosis due to atherosclerosis restricts blood flow. Stenosis progression would lead to increased clinical risk such as heart attack. Although many…”
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