Search Results - "Gibson, Todd J."

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  1. 1
    Application of a high-throughput screening procedure with PEG-induced precipitation to compare relative protein solubility during formulation development with IgG1 monoclonal antibodies

    Application of a high-throughput screening procedure with PEG-induced precipitation to compare relative protein solubility during formulation development with IgG1 monoclonal antibodies by Gibson, Todd J, Mccarty, Katie, Mcfadyen, Iain J, Cash, Ethan, Dalmonte, Paul, Hinds, Kenneth D, Dinerman, Adam A, Alvarez, Juan C, Volkin, David B

    Published in Journal of pharmaceutical sciences (01-03-2011)
    “…Protein solubility is a critical attribute in monoclonal antibody (mAb) formulation development as insolubility issues can negatively impact drug stability,…”
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  2. 2
    Inhibition of insulin fibrillogenesis with targeted peptides

    Inhibition of insulin fibrillogenesis with targeted peptides by Gibson, Todd J., Murphy, Regina M.

    Published in Protein science (01-05-2006)
    “…Under conditions of acidic pH and elevated temperature, insulin partially unfolds and aggregates into highly structured amyloid fibrils. Aggregation of insulin…”
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  3. 3
    Design of Peptidyl Compounds That Affect β-Amyloid Aggregation:  Importance of Surface Tension and Context

    Design of Peptidyl Compounds That Affect β-Amyloid Aggregation:  Importance of Surface Tension and Context by Gibson, Todd J, Murphy, Regina M

    Published in Biochemistry (Easton) (21-06-2005)
    “…Self-association of β-amyloid (Aβ) peptide into cross-β-sheet fibrils induces cellular toxicity in vitro and is linked with progression of Alzheimer's disease…”
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  4. 4
    Targeted Control of Kinetics of β-Amyloid Self-association by Surface Tension-modifying Peptides

    Targeted Control of Kinetics of β-Amyloid Self-association by Surface Tension-modifying Peptides by Kim, Jin Ryoun, Gibson, Todd J., Murphy, Regina M.

    Published in The Journal of biological chemistry (17-10-2003)
    “…Brain tissue from Alzheimer's patients contains extracellular senile plaques composed primarily of deposits of fibrillar aggregates of β-amyloid peptide…”
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  5. 5
    Predicting Solvent and Aggregation Effects of Peptides Using Group Contribution Calculations

    Predicting Solvent and Aggregation Effects of Peptides Using Group Contribution Calculations by Kim, Jin Ryoun, Gibson, Todd J., Murphy, Regina M.

    Published in Biotechnology progress (01-03-2006)
    “…Assembly of proteins and peptides into amyloid fibrils is characteristic of the pathology of a number of degenerative diseases, of which perhaps the best known…”
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  6. 6
    Targeted Control of Kinetics of β-Amyloid Self-association by Surface Tension-modifying Peptides

    Targeted Control of Kinetics of β-Amyloid Self-association by Surface Tension-modifying Peptides by Jin Ryoun Kim, Todd J. Gibson, Regina M. Murphy

    Published in The Journal of biological chemistry (17-10-2003)
    “…Brain tissue from Alzheimer's patients contains extracellular senile plaques composed primarily of deposits of fibrillar aggregates of β-amyloid peptide…”
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