Search Results - "Gibson, Spencer B."

Starvation-induced autophagy is regulated by mitochondrial reactive oxygen species leading to AMPK activation by Li, Lin, Chen, Yongqiang, Gibson, Spencer B.

“…Starvation is the most extensively studied condition that induces autophagy. Previous studies have demonstrated that starvation-induced autophagy is regulated…”
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Ferroptosis and autophagy induced cell death occur independently after siramesine and lapatinib treatment in breast cancer cells by Ma, Shumei, Dielschneider, Rebecca F, Henson, Elizabeth S, Xiao, Wenyan, Choquette, Tricia R, Blankstein, Anna R, Chen, Yongqiang, Gibson, Spencer B

“…Ferroptosis is a cell death pathway characterized by iron-dependent accumulation of reactive oxygen species (ROS) within the cell. The combination of…”
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Regulation of autophagy by reactive oxygen species (ROS): implications for cancer progression and treatment by Azad, Meghan B, Chen, Yongqiang, Gibson, Spencer B

“…Reactive oxygen species (ROS) have been identified as signaling molecules in various pathways regulating both cell survival and cell death. Autophagy, a…”
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A matter of balance between life and death: Targeting reactive oxygen species (ROS)-induced autophagy for cancer therapy by Gibson, Spencer B.

“…Reactive oxygen species (ROS) have been implicated in many biological functions and diseases. Often their role is counterintuitive, where ROS can either…”
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Is mitochondrial generation of reactive oxygen species a trigger for autophagy? by Chen, Yongqiang, Gibson, Spencer B.

“…Autophagy is a conserved lysosomal degradation pathway that has been extensively studied in recent years. However, the mechanism of autophagy induction is…”
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Negative regulators of cell death pathways in cancer: perspective on biomarkers and targeted therapies by Razaghi, Ali, Heimann, Kirsten, Schaeffer, Patrick M., Gibson, Spencer B.

“…Cancer is a primary cause of human fatality and conventional cancer therapies, e.g., chemotherapy, are often associated with adverse side-effects, tumor…”
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Mitochondrial electron-transport-chain inhibitors of complexes I and II induce autophagic cell death mediated by reactive oxygen species by Chen, Yongqiang, McMillan-Ward, Eileen, Kong, Jiming, Israels, Sara J, Gibson, Spencer B

“…Autophagy is a self-digestion process important for cell survival during starvation. It has also been described as a form of programmed cell death…”
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Lysosomes as Oxidative Targets for Cancer Therapy by Dielschneider, Rebecca F., Gibson, Spencer, Henson, Elizabeth S.

“…Lysosomes are membrane-bound vesicles that contain hydrolases for the degradation and recycling of essential nutrients to maintain homeostasis within cells…”
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Surviving cell death through epidermal growth factor (EGF) signal transduction pathways: Implications for cancer therapy by Henson, Elizabeth S., Gibson, Spencer B.

“…There is a balance between cell death and survival in living organisms. The ability of cells to sense their environment and decide to survive or die is…”
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Lysosomal Destabilizing Drug Siramesine and the Dual Tyrosine Kinase Inhibitor Lapatinib Induce a Synergistic Ferroptosis through Reduced Heme Oxygenase-1 (HO-1) Levels by Gibson, Spencer, Konzelman, Carmen, Blankstein, Anna R., Villalpando-Rodriguez, Gloria E.

“…Ferroptosis is an iron-dependent type of cell death distinct from apoptosis or necrosis characterized by accumulation of reactive oxygen species. The…”
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Tyrosine kinase receptor EGFR regulates the switch in cancer cells between cell survival and cell death induced by autophagy in hypoxia by Chen, Yongqiang, Henson, Elizabeth S., Xiao, Wenyan, Huang, Daniel, McMillan-Ward, Eileen M., Israels, Sara J., Gibson, Spencer B.

“…Autophagy is an intracellular lysosomal degradation pathway where its primary function is to allow cells to survive under stressful conditions. Autophagy is,…”
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On-target effect of FK866, a nicotinamide phosphoribosyl transferase inhibitor, by apoptosis-mediated death in chronic lymphocytic leukemia cells by Gehrke, Iris, Bouchard, Eric D J, Beiggi, Sara, Poeppl, Armando G, Johnston, James B, Gibson, Spencer B, Banerji, Versha

“…Chronic lymphocytic leukemia (CLL) remains incurable despite advances in therapy. In this study, we characterize the effect of nicotinamide…”
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Hypoxia induces autophagic cell death in apoptosis-competent cells through a mechanism involving BNIP3 by Azad, Meghan B., Chen, Yongqiang, Henson, Elizabeth S., Cizeau, Jeannick, McMillan-Ward, Eileen, Israels, Sara J., Gibson, Spencer B.

“…Hypoxia (lack of oxygen) is a physiological stress often associated with solid tumors. Hypoxia correlates with poor prognosis since hypoxic regions within…”
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Tumor Suppressing Subtransferable Candidate 4 Expression Prevents Autophagy-Induced Cell Death Following Temozolomide Treatment in Glioblastoma Cells by Chen, Yongqiang, Gibson, Spencer B

“…Glioblastoma (GBM) is the most common and aggressive type of brain cancer in adults, with temozolomide (TMZ) being widely used as the standard chemotherapy…”
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The BH3 only Bcl-2 family member BNIP3 regulates cellular proliferation by Singh, Amandeep, Azad, Meghan, Shymko, Miriam D, Henson, Elizabeth S, Katyal, Sachin, Eisenstat, David D, Gibson, Spencer B

“…The BH3-only family member BNIP3 has been described as either promoting cell survival or cell death. This depends upon the level of BNIP3 expression and its…”
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Real world risk of infusion reactions and effectiveness of front-line obinutuzumab plus chlorambucil compared with other frontline treatments for chronic lymphocytic leukemia by Bourrier, Nicole, Landego, Ivan, Bucher, Oliver, Squires, Mandy, Streu, Erin, Hibbert, Irena, Whiteside, Theresa, Gibson, Spencer B, Geirnaert, Marc, Johnston, James B, Dawe, David E, Banerji, Versha

“…Chronic lymphocytic leukemia (CLL) is the most common type of leukemia in North America. Previous studies have shown improved progression free survival (PFS)…”
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Altered T Follicular Helper Cell Subsets and Function in Chronic Lymphocytic Leukemia by Wu, Xun, Fajardo-Despaigne, J Ernesto, Zhang, Christine, Neppalli, Vishala, Banerji, Versha, Johnston, James B, Gibson, Spencer B, Marshall, Aaron J

“…Follicular helper T cells (T ) have specialized properties in promoting normal B cell activation but their role in chronic lymphocytic leukemia (CLL) is…”
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Lysosome-Disrupting Agents in Combination with Venetoclax Increase Apoptotic Response in Primary Chronic Lymphocytic Leukemia (CLL) Cells Mediated by Lysosomal Cathepsin D Release and Inhibition of Autophagy by Manivannan, Madhumita S, Yang, Xiaoyan, Patel, Nirav, Peters, Anthea, Johnston, James B, Gibson, Spencer B

“…Venetoclax and obinutuzumab are becoming frontline therapies for chronic lymphocytic leukemia (CLL) patients. Unfortunately, drug resistance still occurs, and…”
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Estrogen regulation of anti-apoptotic Bcl-2 family member Mcl-1 expression in breast cancer cells by Schacter, Jennifer L, Henson, Elizabeth S, Gibson, Spencer B

“…Estrogen is implicated as an important factor in stimulating breast cancer cell proliferation, and presence of estrogen receptor (ER) is an indication of a…”
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Differential cellular responses induced by dorsomorphin and LDN‐193189 in chemotherapy‐sensitive and chemotherapy‐resistant human epithelial ovarian cancer cells by Ali, Jennifer L., Lagasse, Brittany J., Minuk, Ainsley J., Love, Allison J., Moraya, Amani I., Lam, Linda, Arthur, Gilbert, Gibson, Spencer B., Morrison, Ludivine Coudière, Werbowetski‐Ogilvie, Tamra E., Fu, Yangxin, Nachtigal, Mark W.

“…Inherent or acquired drug resistance is a major contributor to epithelial ovarian cancer (EOC) mortality. Novel drugs or drug combinations that produce EOC…”
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