Search Results - "Gibson, Jay"

KDM6B cooperates with Tau and regulates synaptic plasticity and cognition via inducing VGLUT1/2 by Wang, Yanan, Khandelwal, Nitin, Liu, Shuiqiao, Zhou, Mi, Bao, Lei, Wang, Jennifer E., Kumar, Ashwani, Xing, Chao, Gibson, Jay R., Wang, Yingfei

“…The excitatory neurotransmitter glutamate shapes learning and memory, but the underlying epigenetic mechanism of glutamate regulation in neuron remains poorly…”
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Experience-Induced Arc/Arg3.1 Primes CA1 Pyramidal Neurons for Metabotropic Glutamate Receptor-Dependent Long-Term Synaptic Depression by Jakkamsetti, Vikram, Tsai, Nien-Pei, Gross, Christina, Molinaro, Gemma, Collins, Katie A., Nicoletti, Ferdinando, Wang, Kuan H., Osten, Pavel, Bassell, Gary J., Gibson, Jay R., Huber, Kimberly M.

“…A novel experience induces the Arc/Arg3.1 gene as well as plasticity of CA1 neural networks. To understand how these are linked, we briefly exposed GFP…”
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Imbalance of Neocortical Excitation and Inhibition and Altered UP States Reflect Network Hyperexcitability in the Mouse Model of Fragile X Syndrome by Gibson, Jay R, Bartley, Aundrea F, Hays, Seth A, Huber, Kimberly M

“…University of Texas Southwestern Medical Center, Department of Neuroscience, Dallas, Texas Submitted 8 July 2008; accepted in final form 4 September 2008…”
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Small molecules enable neurogenin 2 to efficiently convert human fibroblasts into cholinergic neurons by Liu, Meng-Lu, Zang, Tong, Zou, Yuhua, Chang, Joshua C., Gibson, Jay R., Huber, Kimberly M., Zhang, Chun-Li

“…Cell fate can be reprogrammed by modifying intrinsic and extrinsic cues. Here we show that two small molecules (forskolin and dorsomorphin) enable the…”
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Increased Cortical Inhibition in Autism-Linked Neuroligin-3R451C Mice Is Due in Part to Loss of Endocannabinoid Signaling by Speed, Haley E, Masiulis, Irene, Gibson, Jay R, Powell, Craig M

“…A single, maternally inherited, X-linked point mutation leading to an arginine to cysteine substitution at amino acid 451 (R451C) of Neuroligin 3 (NLGN3R451C)…”
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Altered neocortical rhythmic activity states in Fmr1 KO mice are due to enhanced mGluR5 signaling and involve changes in excitatory circuitry by Hays, Seth A, Huber, Kimberly M, Gibson, Jay R

“…Despite the pronounced neurological deficits associated with mental retardation and autism, the degree to which neocortical circuit function is altered remains…”
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Local cortical circuit correlates of altered EEG in the mouse model of Fragile X syndrome by Goswami, Sonal, Cavalier, Sheridan, Sridhar, Vinay, Huber, Kimberly M., Gibson, Jay R.

“…Electroencephalogram (EEG) recordings in Fragile X syndrome (FXS) patients have revealed enhanced sensory responses, enhanced resting “gamma frequency”…”
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Activity-Dependent Validation of Excitatory versus Inhibitory Synapses by Neuroligin-1 versus Neuroligin-2 by Chubykin, Alexander A., Atasoy, Deniz, Etherton, Mark R., Brose, Nils, Kavalali, Ege T., Gibson, Jay R., Südhof, Thomas C.

“…Neuroligins enhance synapse formation in vitro, but surprisingly are not required for the generation of synapses in vivo. We now show that in cultured neurons,…”
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Audiogenic Seizures in the Fmr1 Knock-Out Mouse Are Induced by Fmr1 Deletion in Subcortical, VGlut2-Expressing Excitatory Neurons and Require Deletion in the Inferior Colliculus by Gonzalez, Darya, Tomasek, Madison, Hays, Seth, Sridhar, Vinay, Ammanuel, Simon, Chang, Chia-Wei, Pawlowski, Karen, Huber, Kimberly M, Gibson, Jay R

“…Fragile X syndrome (FXS) is the most common form of inherited intellectual disability and the leading monogenetic cause of autism. One symptom of FXS and…”
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FOXP1 negatively regulates intrinsic excitability in D2 striatal projection neurons by promoting inwardly rectifying and leak potassium currents by Khandelwal, Nitin, Cavalier, Sheridan, Rybalchenko, Volodymyr, Kulkarni, Ashwinikumar, Anderson, Ashley G., Konopka, Genevieve, Gibson, Jay R.

“…Heterozygous loss-of-function mutations in the transcription factor FOXP1 are strongly associated with autism. Dopamine receptor 2 expressing (D2) striatal…”
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Increased Expression of the PI3K Enhancer PIKE Mediates Deficits in Synaptic Plasticity and Behavior in Fragile X Syndrome by Gross, Christina, Chang, Chia-Wei, Kelly, Seth M., Bhattacharya, Aditi, McBride, Sean M.J., Danielson, Scott W., Jiang, Michael Q., Chan, Chi Bun, Ye, Keqiang, Gibson, Jay R., Klann, Eric, Jongens, Thomas A., Moberg, Kenneth H., Huber, Kimberly M., Bassell, Gary J.

“…The PI3K enhancer PIKE links PI3K catalytic subunits to group 1 metabotropic glutamate receptors (mGlu1/5) and activates PI3K signaling. The roles of PIKE in…”
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Experience-dependent weakening of callosal synaptic connections in the absence of postsynaptic FMRP by Zhang, Zhe, Gibson, Jay R, Huber, Kimberly M

“…Reduced structural and functional interhemispheric connectivity correlates with the severity of Autism Spectrum Disorder (ASD) behaviors in humans. Little is…”
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A dual shaping mechanism for postsynaptic ephrin-B3 as a receptor that sculpts dendrites and synapses by Henkemeyer, Mark, Xu, Nan-Jie, Sun, Suya, Gibson, Jay R

“…Examining the role of ephrin-B3 in dendritic and synaptic development in vivo , this study finds that ephrin-B3 functions postsynaptically as a receptor to…”
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Disrupted Homer scaffolds mediate abnormal mGluR5 function in a mouse model of fragile X syndrome by Ronesi, Jennifer A, Collins, Katie A, Hays, Seth A, Tsai, Nien-Pei, Guo, Weirui, Birnbaum, Shari G, Hu, Jia-Hua, Worley, Paul F, Gibson, Jay R, Huber, Kimberly M

“…This study shows that the interaction between metabotropic glutamate receptor 5 (mGluR5) and a specific form of the scaffolding protein Homer contributes to…”
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FoxP1 orchestration of ASD-relevant signaling pathways in the striatum by Araujo, Daniel J, Anderson, Ashley G, Berto, Stefano, Runnels, Wesley, Harper, Matthew, Ammanuel, Simon, Rieger, Michael A, Huang, Hung-Chung, Rajkovich, Kacey, Loerwald, Kristofer W, Dekker, Joseph D, Tucker, Haley O, Dougherty, Joseph D, Gibson, Jay R, Konopka, Genevieve

“…Mutations in the transcription factor Forkhead box p1 (FOXP1) are causative for neurodevelopmental disorders such as autism. However, the function of FOXP1…”
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Selective Role of the Catalytic PI3K Subunit p110β in Impaired Higher Order Cognition in Fragile X Syndrome by Gross, Christina, Raj, Nisha, Molinaro, Gemma, Allen, Amanda G., Whyte, Alonzo J., Gibson, Jay R., Huber, Kimberly M., Gourley, Shannon L., Bassell, Gary J.

“…Distinct isoforms of the PI3K catalytic subunit have specialized functions in the brain, but their role in cognition is unknown. Here, we show that the…”
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A sound-driven cortical phase-locking change in the Fmr1 KO mouse requires Fmr1 deletion in a subpopulation of brainstem neurons by Holley, Andrew J., Shedd, Aleya, Boggs, Anna, Lovelace, Jonathan, Erickson, Craig, Gross, Christina, Jankovic, Miranda, Razak, Khaleel, Huber, Kimberly, Gibson, Jay R.

“…Sensory impairments commonly occur in patients with autism or intellectual disability. Fragile X syndrome (FXS) is one form of intellectual disability that is…”
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Compensation between FOXP transcription factors maintains proper striatal function by Ahmed, Newaz I., Khandelwal, Nitin, Anderson, Ashley G., Oh, Emily, Vollmer, Rachael M., Kulkarni, Ashwinikumar, Gibson, Jay R., Konopka, Genevieve

“…Spiny projection neurons (SPNs) of the striatum are critical in integrating neurochemical information to coordinate motor and reward-based behavior. Mutations…”
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Female-specific dysfunction of sensory neocortical circuits in a mouse model of autism mediated by mGluR5 and estrogen receptor α by Molinaro, Gemma, Bowles, Jacob E., Croom, Katilynne, Gonzalez, Darya, Mirjafary, Saba, Birnbaum, Shari G., Razak, Khaleel A., Gibson, Jay R., Huber, Kimberly M.

“…Little is known of the brain mechanisms that mediate sex-specific autism symptoms. Here, we demonstrate that deletion of the autism spectrum disorder…”
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Vasoactive intestinal polypeptide (VIP)-expressing neurons in the suprachiasmatic nucleus provide sparse GABAergic outputs to local neurons with circadian regulation occurring distal to the opening of postsynaptic GABAA ionotropic receptors by Fan, Junmei, Zeng, Hongkui, Olson, David P, Huber, Kimberly M, Gibson, Jay R, Takahashi, Joseph S

“…GABAergic synaptic transmission plays an important role in resetting and synchronizing circadian rhythms in the suprachiasmatic nucleus (SCN). Although the…”
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