Search Results - "Gibson, G.Gordon"

Peroxisome proliferators: paradigms and prospects by Gibson, G G

“…Peroxisome proliferators are a structurally diverse group of chemicals. They include fibrate hypolipidaemic drugs, phthalate ester plasticisers, phenoxy acid…”
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On the mechanism of induction of microsomal cytochrome P450IVA1 and peroxisome proliferation in rat liver by clofibrate by Milton, M N, Elcombe, C R, Gibson, G G

“…The time course of induction of microsomal and peroxisomal lipid-metabolizing enzymes in male Wistar rat liver has been investigated following a single i.p…”
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Differential induction of cytochromes P450 and cytochrome P450-dependent arachidonic acid metabolism by 3,4,5,3',4'-pentachlorobiphenyl in the rat and the guinea pig by Huang, S, Gibson, G G

“…Differential induction of hepatic cytochromes P450 by 3,4,5,3',4'-pentachlorobiphenyl (PENCB) has been observed in the rat and the guinea pig: (1) in rat and…”
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Role of hepatic and renal cytochrome P-450 IVA1 in the metabolism of lipid substrates by Sharma, R K, Doig, M V, Lewis, D F, Gibson, G G

“…The role of clofibrate-inducible cytochrome P-450 IVA1 in the metabolism of endogenous lipids in both rat liver and kidney microsomal fractions has been…”
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Lansoprazole increases testosterone metabolism and clearance in male Sprague-Dawley rats: implications for leydig cell carcinogenesis by Coulson, Michelle, Gibson, G.Gordon, Plant, Nick, Hammond, Tim, Graham, Mark

“…Leydig cell tumours (LCTs) are frequently observed during rodent carcinogenicity studies, however, the significance of this effect to humans remains a matter…”
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Receptor-dependent regulation of the CYP3A4 gene by Gibson, G.Gordon, El-Sankary, Wafaa, Plant, Nick J

“…A CYP3A4 promoter–reporter gene construct has been used to assess the ability of 16 known (in vivo) and putative (in vitro) inducers to transactivate a CYP3A4…”
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The transcription of the peroxisome proliferator-activated receptor α gene is regulated by protein kinase C by Yaacob, Nik-Soriani, Norazmi, Mohd-Nor, Gibson, G.Gordon, Kass, George E.N.

“…The transcriptional regulation of peroxisome proliferator-activated receptor α (PPARα) by a variety of peroxisome proliferators was investigated. The treatment…”
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Control and Statistical Analysis of in Vitro Reporter Gene Assays by Plant, Nick J., Ogg, Malcolm, Crowder, Martin, Gibson, G.Gordon

“…The use of in vitro gene reporter assays is becoming increasingly widespread in biology and particularly in drug metabolism, where the need for rapid screening…”
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Use of suppression-PCR subtractive hybridisation to identify genes that demonstrate altered expression in male rat and guinea pig livers following exposure to Wy-14,643, a peroxisome proliferator and non-genotoxic hepatocarcinogen by Rockett, John C, Swales, Karen E, Esdaile, David J, Gibson, G.Gordon

“…Understanding the genetic profile of a cell at all stages of normal and carcinogenic development should provide an essential aid to developing new strategies…”
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Co-induction of microsomal cytochrome P-452 and the peroxisomal fatty acid beta-oxidation pathway in the rat by clofibrate and di-(2-ethylhexyl)phthalate. Dose-response studies by Sharma, R, Lake, B G, Gibson, G G

“…Male Wistar rats have been pretreated with either clofibrate or diethylhexylphthalate and the dose-dependency of induction of the microsomal, cytochrome…”
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Species and congener specific induction of hepatic cytochrome P4504A by polychlorinated biphenyls by Huang, S, Gibson, G G

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Stereochemical selectivity in the induction of cytochrome P450IVA1 (P452)-dependent fatty acid hydroxylation and peroxisome proliferation by Chinje, E, Gibson, G G

“…Induction of hepatic microsomal cytochrome P450IVA1 and peroxisomal enzymes of the beta-oxidation spiral were observed when male Long Evans hooded rats were…”
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Differential splicing in the 3′ non-coding region of rat cytochrome P-452 (P450 IVA1) mRNA by Earnshaw, David, Dale, Jeremy W., Goldfarb, Peter S., Gibson, G.Gordon

“…The gene coding for the clofibrate-induced cytochrome P-452 has been isolated from a cDNA library and a full-length cDNA clone sequenced. The sequence was…”
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Immunochemical study on the contribution of hypolipidaemic-induced cytochrome P-452 to the metabolism of lauric acid and arachidonic acid by Bains, S K, Gardiner, S M, Mannweiler, K, Gillett, D, Gibson, G G

“…The influence of four hypolipidaemic drugs (clofibrate, WY-14,643, clobuzarit and bezafibrate) on hepatic cytochrome P-450 and fatty acid metabolism in male…”
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Cysteine conjugate beta-lyase of rat kidney cytosol: characterization, immunocytochemical localization, and correlation with hexachlorobutadiene nephrotoxicity by MacFarlane, M, Foster, J R, Gibson, G G, King, L J, Lock, E A

“…Cysteine conjugate beta-lyase (beta-lyase) was purified to electrophoretic homogeneity from the kidney cytosol of male Wistar rats. The highly purified enzyme…”
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Biochemical pharmacology and toxicology volume 1, methodological aspects of drug metabolizing enzymes : Edited by D. Zakim and D.A. Vessey John Wiley; New York and Chichester, 1985 372 pages. £66.50 by Gibson, G.Gordon

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Biochemical pharmacology and toxicology volume 1, methodological aspects of drug metabolizing enzymes by Gibson, G.Gordon

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Lack of evidence for a hepatic peroxisome proliferator receptor and an explanation for the binding of hypolipidaemic drugs to liver homogenates by Milton, M N, Elcombe, C R, Kass, G E, Gibson, G G

“…The existence of a postulated hepatic receptor responsible for the peroxisomal proliferation induced in rodents by hypolipidaemic drugs has been investigated…”
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Lauric acid hydroxylase activity and cytochrome P450 IV family proteins in human liver microsomes by Dirven, H A, Peters, J G, Gibson, G G, Peters, W H, Jongeneelen, F J

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Chlorophenoxyacid herbicides induce microsomal cytochrome P-450 IVA1 (P-452) in rat liver by Bacher, M A, Gibson, G G

“…Induction of the cytochrome P-450 mixed-function oxidase and specifically the cytochrome P-450 IVA1 isoenzyme by seven phenoxyacid herbicides in rat liver have…”
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