Priorities for future research into asthma diagnostic tools: A PAN‐EU consensus exercise from the European asthma research innovation partnership (EARIP)

Summary The diagnosis of asthma is currently based on clinical history, physical examination and lung function, and to date, there are no accurate objective tests either to confirm the diagnosis or to discriminate between different types of asthma. This consensus exercise reviews the state of the ar...

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Published in:	Clinical and experimental allergy Vol. 48; no. 2; pp. 104 - 120
Main Authors:	Garcia‐Marcos, L., Edwards, J., Kennington, E., Aurora, P., Baraldi, E., Carraro, S., Gappa, M., Louis, R., Moreno‐Galdo, A., Peroni, D. G., Pijnenburg, M., Priftis, K. N., Sanchez‐Solis, M., Schuster, A., Walker, S., Blakey, John, Compton, Chris, Fleming, Louise, Fowler, Steve, Gaillard, Erol, Gibson, Frankie, Glenn Crater, Glenn, Niven, Rob, Roberts, Amanda, Ryan, Dermot, Seppala, Ulla, Usmani, Omar, Schee, Marc, Sont, Jacob
Format:	Journal Article Web Resource
Language:	English
Published:	England Wiley Subscription Services, Inc 01-02-2018 Blackwell Publishing Ltd
Subjects:	Asthma Asthma - diagnosis Biomarkers Breath Tests Cardiovascular & respiratory systems Children Consensus Delphi study Diagnosis Diagnostic software Europe Health Priorities Human health sciences Humans Innovations Literature reviews Lungs Medical personnel Metabolomics Metabolomics - methods Occupational health Organic compounds Prognosis Proteomics Respiratory function Respiratory Function Tests Review Sciences de la santé humaine Systèmes cardiovasculaire & respiratoire VOCs Volatile organic compounds Europe
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Summary:	Summary The diagnosis of asthma is currently based on clinical history, physical examination and lung function, and to date, there are no accurate objective tests either to confirm the diagnosis or to discriminate between different types of asthma. This consensus exercise reviews the state of the art in asthma diagnosis to identify opportunities for future investment based on the likelihood of their successful development, potential for widespread adoption and their perceived impact on asthma patients. Using a two‐stage e‐Delphi process and a summarizing workshop, a group of European asthma experts including health professionals, researchers, people with asthma and industry representatives ranked the potential impact of research investment in each technique or tool for asthma diagnosis and monitoring. After a systematic review of the literature, 21 statements were extracted and were subject of the two‐stage Delphi process. Eleven statements were scored 3 or more and were further discussed and ranked in a face‐to‐face workshop. The three most important diagnostic/predictive tools ranked were as follows: “New biological markers of asthma (eg genomics, proteomics and metabolomics) as a tool for diagnosis and/or monitoring,” “Prediction of future asthma in preschool children with reasonable accuracy” and “Tools to measure volatile organic compounds (VOCs) in exhaled breath.”
Bibliography:	Funding information EU FP7 Grant agreement no: 602077 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 scopus-id:2-s2.0-85041119034
ISSN:	0954-7894 1365-2222 1365-2222
DOI:	10.1111/cea.13080