Search Results - "Gibson, Elizabeth G"

Structural and Biochemical Basis of Etoposide-Resistant Mutations in Topoisomerase IIα by Gibson, Elizabeth G., Deweese, Joseph E.

“…Etoposide is a widely used anticancer drug that targets type II topoisomerases, including topoisomerase IIα (TOP2A). TOP2A is a nuclear enzyme involved in…”
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Mechanism of Action of Mycobacterium tuberculosis Gyrase Inhibitors: A Novel Class of Gyrase Poisons by Gibson, Elizabeth G, Blower, Tim R, Cacho, Monica, Bax, Ben, Berger, James M, Osheroff, Neil

“…Tuberculosis is one of the leading causes of morbidity worldwide, and the incidences of drug resistance and intolerance are prevalent. Thus, there is a…”
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Mechanistic and Structural Basis for the Actions of the Antibacterial Gepotidacin against Staphylococcus aureus Gyrase by Gibson, Elizabeth G, Bax, Ben, Chan, Pan F, Osheroff, Neil

“…Gepotidacin is a first-in-class triazaacenaphthylene novel bacterial topoisomerase inhibitor (NBTI). The compound has successfully completed phase II trials…”
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Bimodal Actions of a Naphthyridone/Aminopiperidine-Based Antibacterial That Targets Gyrase and Topoisomerase IV by Gibson, Elizabeth G, Oviatt, Alexandria A, Cacho, Monica, Neuman, Keir C, Chan, Pan F, Osheroff, Neil

“…Gyrase and topoisomerase IV are the targets of fluoroquinolone antibacterials. However, the rise in antimicrobial resistance has undermined the clinical use of…”
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Population pharmacokinetic analysis of crizotinib in children with progressive/recurrent high-grade and diffuse intrinsic pontine gliomas by Gibson, Elizabeth G., Campagne, Olivia, Selvo, Nicholas S., Gajjar, Amar, Stewart, Clinton F.

“…Purpose Crizotinib, a potent oral tyrosine kinase inhibitor, was evaluated in combination with dasatinib in a phase 1 trial (NCT01644773) in children with…”
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LC-MS/MS method for quantitation of gemcitabine and its metabolite 2′,2′-difluoro-2′-deoxyuridine in mouse plasma and brain tissue: Application to a preclinical pharmacokinetic study by Zhong, Bo, Gibson, Elizabeth G., Davis, Abi, Roussel, Martine F., Stewart, Clinton F.

“…•A simple, fast, and robust method was developed and validated to measure dFdC and dFdU in mouse plasma and brain tissue.•Extraction of dFdC and dFdU was…”
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Two-Mechanism Model for the Interaction of Etoposide Quinone with Topoisomerase IIα by Gibson, Elizabeth G, King, McKenzie M, Mercer, Susan L, Deweese, Joseph E

“…Topoisomerase II is an essential nuclear enzyme involved in regulating DNA topology to facilitate replication and cell division. Disruption of topoisomerase II…”
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Interactions between Gepotidacin and Escherichia coli Gyrase and Topoisomerase IV: Genetic and Biochemical Evidence for Well-Balanced Dual-Targeting by Oviatt, Alexandria A., Gibson, Elizabeth G., Huang, Jianzhong, Mattern, Karen, Neuman, Keir C., Chan, Pan F., Osheroff, Neil

“…Antimicrobial resistance is a global threat to human health. Therefore, efforts have been made to develop new antibacterial agents that address this critical…”
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Etoposide Catechol Is an Oxidizable Topoisomerase II Poison by Jacob, David A, Gibson, Elizabeth G, Mercer, Susan L, Deweese, Joseph E

“…Topoisomerase II regulates DNA topology by generating transient double-stranded breaks. The anticancer drug etoposide targets topoisomerase II and is…”
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Abstract 3031: Characterization of gemcitabine triphosphate formation in mice to aid in the development of a translational tumor model by Gibson, Elizabeth G., Davis, Abi, Zhong, Bo, Campagne, Olivia, Roussel, Martine F., Stewart, Clinton F.

“…Gemcitabine (dFdC), a cytosine analog, is currently being evaluated in combination with other chemotherapeutic agents as therapy to treat children and young…”
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Etoposide Catechol Is an Oxidizable Topoisomerase II Poison by Deweese, Joseph E., Jacob, David A., Gibson, Elizabeth G., Mercer, Susan L.

“…Abstract only Topoisomerase II is an essential nuclear enzyme involved in DNA metabolism. Anticancer drugs capitalize on the potentially genotoxic catalytic…”
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Biomedical Applications in Primatology by Gibson, Elizabeth G.

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Web Places: Project-Based Activities for At-Risk Youth by Jenifer L. Wheeler, Todd M. Miller, Harry M. Halff, Ruben Fernandez, Lawrence A. Halff, Elizabeth G. Gibson, Thomas N. Meyer

“…This paper describes the development and evaluation of Web Places, a prototype web-based template system that allowed students at risk of academic failure to…”
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