Search Results - "Gibson, Christopher C."

Cell Painting, a high-content image-based assay for morphological profiling using multiplexed fluorescent dyes by Bray, Mark-Anthony, Singh, Shantanu, Han, Han, Davis, Chadwick T, Borgeson, Blake, Hartland, Cathy, Kost-Alimova, Maria, Gustafsdottir, Sigrun M, Gibson, Christopher C, Carpenter, Anne E

“…Cell Painting is a high-content screening assay that uses multiplexed fluorescent dyes for image-based profiling of ∼1,500 morphological features. Image…”
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Dietary Vitamin D and Its Metabolites Non-Genomically Stabilize the Endothelium by Gibson, Christopher C, Davis, Chadwick T, Zhu, Weiquan, Bowman-Kirigin, Jay A, Walker, Ashley E, Tai, Zhengfu, Thomas, Kirk R, Donato, Anthony J, Lesniewski, Lisa A, Li, Dean Y

“…Vitamin D is a known modulator of inflammation. Native dietary vitamin D3 is thought to be bio-inactive, and beneficial vitamin D3 effects are thought to be…”
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Interleukin receptor activates a MYD88–ARNO–ARF6 cascade to disrupt vascular stability by Zhu, Weiquan, London, Nyall R., Gibson, Christopher C., Davis, Chadwick T., Tong, Zongzhong, Sorensen, Lise K., Shi, Dallas S., Guo, Jinping, Smith, Matthew C. P., Grossmann, Allie H., Thomas, Kirk R., Li, Dean Y.

“…Interleukin-1β-induced disruption to endothelial stability and vascular permeability in a human in vitro model is shown to be independent of downstream nuclear…”
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Cationic PAMAM Dendrimers Disrupt Key Platelet Functions by Jones, Clinton F, Campbell, Robert A, Franks, Zechariah, Gibson, Christopher C, Thiagarajan, Giridhar, Vieira-de-Abreu, Adriana, Sukavaneshvar, Sivaprasad, Mohammad, S. Fazal, Li, Dean Y, Ghandehari, Hamidreza, Weyrich, Andrew S, Brooks, Benjamin D, Grainger, David W

“…Poly(amidoamine) (PAMAM) dendrimers have been proposed for a variety of biomedical applications and are increasingly studied as model nanomaterials for such…”
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Intravitreal AAV2.COMP-Ang1 Prevents Neurovascular Degeneration in a Murine Model of Diabetic Retinopathy by Cahoon, Judd M, Rai, Ruju R, Carroll, Lara S, Uehara, Hironori, Zhang, Xiaohui, O'Neil, Christina L, Medina, Reinhold J, Das, Subtrata K, Muddana, Santosh K, Olson, Paul R, Nielson, Spencer, Walker, Kortnie, Flood, Maggie M, Messenger, Wyatt B, Archer, Bonnie J, Barabas, Peter, Krizaj, David, Gibson, Christopher C, Li, Dean Y, Koh, Gou Y, Gao, Guangping, Stitt, Alan W, Ambati, Balamurali K

“…Diabetic retinopathy (DR) is the leading cause of blindness in the working-age population in the U.S. The vision-threatening processes of neuroglial and…”
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Mutations in 2 distinct genetic pathways result in cerebral cavernous malformations in mice by Chan, Aubrey C, Drakos, Stavros G, Ruiz, Oscar E, Smith, Alexandra C H, Gibson, Christopher C, Ling, Jing, Passi, Samuel F, Stratman, Amber N, Sacharidou, Anastasia, Revelo, M Patricia, Grossmann, Allie H, Diakos, Nikolaos A, Davis, George E, Metzstein, Mark M, Whitehead, Kevin J, Li, Dean Y

“…Cerebral cavernous malformations (CCMs) are a common type of vascular malformation in the brain that are a major cause of hemorrhagic stroke. This condition…”
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ARF6 inhibition stabilizes the vasculature and enhances survival during endotoxic shock by Davis, Chadwick T, Zhu, Weiquan, Gibson, Christopher C, Bowman-Kirigin, Jay A, Sorensen, Lise, Ling, Jing, Sun, Huiming, Navankasattusas, Sutip, Li, Dean Y

“…The vascular endothelium responds to infection by destabilizing endothelial cell-cell junctions to allow fluid and cells to pass into peripheral tissues,…”
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Lack of CCM1 induces hypersprouting and impairs response to flow by Mleynek, Tara M, Chan, Aubrey C, Redd, Michael, Gibson, Christopher C, Davis, Chadwick T, Shi, Dallas S, Chen, Tiehua, Carter, Kandis L, Ling, Jing, Blanco, Raquel, Gerhardt, Holger, Whitehead, Kevin, Li, Dean Y

“…Cerebral cavernous malformation (CCM) is a disease of vascular malformations known to be caused by mutations in one of three genes: CCM1, CCM2 or CCM3. Despite…”
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Differential effects of cyclic stretch on bFGF- and VEGF-induced sprouting angiogenesis by Wilkins, Justin R., Pike, Daniel B., Gibson, Christopher C., Kubota, Atsutoshi, Shiu, Yan-Ting

“…How mechanical factors affect angiogenesis and how they and chemical angiogenic factors work in concert remain not yet well‐understood. This study investigated…”
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Novel Approach for Endothelializing Vascular Devices: Understanding and Exploiting Elastin-Endothelial Interactions by Wilson, Brent D, Gibson, Christopher C, Sorensen, Lise K, Guilhermier, Margaret Yoklavich, Clinger, Melissa, Kelley, Linda L, Shiu, Yan-Ting E, Li, Dean Y

“…Elastin is an essential component of arteries which provides structural integrity and instructs smooth muscle cells to adopt a quiescent state. Despite…”
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High-resolution genome-wide mapping of chromosome-arm-scale truncations induced by CRISPR–Cas9 editing by Lazar, Nathan H., Celik, Safiye, Chen, Lu, Fay, Marta M., Irish, Jonathan C., Jensen, James, Tillinghast, Conor A., Urbanik, John, Bone, William P., Gibson, Christopher C., Haque, Imran S.

“…Clustered regularly interspaced short palindromic repeats (CRISPR)–CRISPR-associated protein 9 (Cas9) is a powerful tool for introducing targeted mutations in…”
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Strategy for identifying repurposed drugs for the treatment of cerebral cavernous malformation by Gibson, Christopher C, Zhu, Weiquan, Davis, Chadwick T, Bowman-Kirigin, Jay A, Chan, Aubrey C, Ling, Jing, Walker, Ashley E, Goitre, Luca, Delle Monache, Simona, Retta, Saverio Francesco, Shiu, Yan-Ting E, Grossmann, Allie H, Thomas, Kirk R, Donato, Anthony J, Lesniewski, Lisa A, Whitehead, Kevin J, Li, Dean Y

“…Cerebral cavernous malformation (CCM) is a hemorrhagic stroke disease affecting up to 0.5% of North Americans that has no approved nonsurgical treatment. A…”
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The interplay of cyclic stretch and vascular endothelial growth factor in regulating the initial steps for angiogenesis by Wilkins, Justin R., Pike, Daniel B., Gibson, Christopher C., Li, Li, Shiu, Yan-Ting

“…Angiogenesis is regulated by chemical and mechanical factors in vivo. The regulatory role of mechanical factors and how chemical and mechanical angiogenic…”
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Peripheral plasma vitamin D and non-HDL cholesterol reflect the severity of cerebral cavernous malformation disease by Girard, Romuald, Khanna, Omaditya, Shenkar, Robert, Zhang, Lingjiao, Wu, Meijing, Jesselson, Michael, Zeineddine, Hussein A, Gangal, Anupriya, Fam, Maged D, Gibson, Christopher C, Whitehead, Kevin J, Li, Dean Y, Liao, James K, Shi, Changbin, Awad, Issam A

“…To correlate cerebral cavernous malformations (CCMs) disease aggressiveness with peripheral blood biomarkers hypothesized mechanistically. A prospective…”
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Proceedings of the fifth international RASopathies symposium: When development and cancer intersect by Rauen, Katherine A., Schoyer, Lisa, Schill, Lisa, Stronach, Beth, Albeck, John, Andresen, Brage S., Cavé, Hélène, Ellis, Michelle, Fruchtman, Steven M., Gelb, Bruce D., Gibson, Christopher C., Gripp, Karen, Hefner, Erin, Huang, William Y. C., Itkin, Maxim, Kerr, Bronwyn, Linardic, Corinne M., McMahon, Martin, Oberlander, Beverly, Perlstein, Ethan, Ratner, Nancy, Rogers, Leslie, Schenck, Annette, Shankar, Suma, Shvartsman, Stanislav, Stevenson, David A., Stites, Edward C., Stork, Philip J. S., Sun, Cheng, Therrien, Marc, Ullian, Erik M., Widemann, Brigitte C., Yeh, Erika, Zampino, Giuseppe, Zenker, Martin, Timmer, William, McCormick, Frank

“…This report summarizes and highlights the fifth International RASopathies Symposium: When Development and Cancer Intersect, held in Orlando, Florida in July…”
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Mutations in 2 distinct genetic pathways result in cerebral cavernous malformations in mice by Chan, Aubrey C, Drakos, Stavros G, Ruiz, Oscar E, Smith, Alexandra C.H, Gibson, Christopher C, Ling, Jing, Passi, Samuel F, Stratman, Amber N, Sacharidou, Anastasia, Revelo, M. Patricia, Grossmann, Allie H, Diakos, Nikolaos A, Davis, George E, Metzstein, Mark M, Whitehead, Kevin J, Li, Dean Y

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Abstract 56: Plasma Vitamin D and Non-HDL Cholesterol Reflect the Disease Severity of Cerebral Cavernous Malformation by Girard, Romuald, Khanna, Omaditya, Jesselson, Michael, Zhang, Lingjiao, Shenkar, Robert, Gangal, Anupriya, Fam, Maged, Gibson, Christopher C, Whitehead, Kevin J, Li, Dean Y, Liao, James K, Shi, Changbin, Awad, Issam A

“…Abstract only Introduction and Hypothesis: Cerebral cavernous malformations (CCMs) are common cerebrovascular anomalies with highly variable but potentially…”
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Identification of novel treatments for a hereditary stroke disorder using quantitative phenotypic fingerprinting by Gibson, Christopher C

“…Destabilization of the endothelial monolayer lining blood vessels has profound consequences on organismal homeostasis. Vascular instability plays a well-known…”
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Dietary Vitamin D and Its Metabolites Non-Genomically Stabilize the Endothelium: e0140370 by Gibson, Christopher C, Davis, Chadwick T, Zhu, Weiquan, Bowman-Kirigin, Jay A, Walker, Ashley E, Tai, Zhengfu, Thomas, Kirk R, Donato, Anthony J, Lesniewski, Lisa A, Li, Dean Y

“…Vitamin D is a known modulator of inflammation. Native dietary vitamin D3 is thought to be bio-inactive, and beneficial vitamin D3 effects are thought to be…”
Get full text