Search Results - "Gibson, Carolyn W."

Leucine rich amelogenin peptide prevents ovariectomy-induced bone loss in mice by Haruyama, Naoto, Yamaza, Takayoshi, Suzuki, Shigeki, Hall, Bradford, Cho, Andrew, Gibson, Carolyn W, Kulkarni, Ashok B

“…Amelogenins, major extra cellular matrix proteins of developing tooth enamel, are predominantly expressed by ameloblasts and play significant roles in the…”
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Weaker dental enamel explains dental decay by Vieira, Alexandre R, Gibson, Carolyn W, Deeley, Kathleen, Xue, Hui, Li, Yong

“…Dental caries continues to be the most prevalent bacteria-mediated non-contagious disease of humankind. Dental professionals assert the disease can be…”
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Analysis of enamel development using murine model systems: approaches and limitations by Pugach, Megan K, Gibson, Carolyn W

“…A primary goal of enamel research is to understand and potentially treat or prevent enamel defects related to amelogenesis imperfecta (AI). Rodents are ideal…”
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Wnt-RhoA signaling is involved in dental enamel development by Peng, Li, Li, Yong, Shusterman, Kate, Kuehl, Melissa, Gibson, Carolyn W.

“…Peng L, Li Y, Shusterman K, Kuehl M, Gibson CW. Wnt‐RhoA signaling is involved in dental enamel development. 
 Eur J Oral Sci 2011; 119 (Suppl. 1): 41–49. ©…”
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Human and mouse enamel phenotypes resulting from mutation or altered expression of AMEL, ENAM, MMP20 and KLK4 by Wright, J Timothy, Hart, Thomas C, Hart, P Suzanne, Simmons, Darrin, Suggs, Cynthia, Daley, Bill, Simmer, Jim, Hu, Jan, Bartlett, John D, Li, Yong, Yuan, Zhi-An, Seow, W Kim, Gibson, Carolyn W

“…Amelogenesis imperfecta (AI) is caused by AMEL, ENAM, MMP20 and KLK4 gene mutations. Mice lacking expression of the AmelX, Enam and Mmp20 genes have been…”
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TGF-ß regulates enamel mineralization and maturation through KLK4 expression by Cho, Andrew, Haruyama, Naoto, Hall, Bradford, Danton, Mary Jo S, Zhang, Lu, Arany, Praveen, Mooney, David J, Harichane, Yassine, Goldberg, Michel, Gibson, Carolyn W, Kulkarni, Ashok B

“…Transforming growth factor-ß (TGF-ß) signaling plays an important role in regulating crucial biological processes such as cell proliferation, differentiation,…”
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The role of amelogenin during enamel-crystallite growth and organization in vivo by Wright, J. Tim, Li, Yong, Suggs, Cynthia, Kuehl, Melissa A., Kulkarni, Ashok B., Gibson, Carolyn W.

“…Wright JT, Li Y, Suggs C, Kuehl MA, Kulkarni AB, Gibson CW. The role of amelogenin during enamel‐crystallite growth and organization in vivo. 
Eur J Oral Sci…”
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Ameloblasts require active RhoA to generate normal dental enamel by Xue, Hui, Li, Yong, Everett, Eric T., Ryan, Kathleen, Peng, Li, Porecha, Rakhee, Yan, Yan, Lucchese, Anna M., Kuehl, Melissa A., Pugach, Megan K., Bouchard, Jessica, Gibson, Carolyn W.

“…RhoA plays a fundamental role in regulation of the actin cytoskeleton, intercellular attachment, and cell proliferation. During amelogenesis, ameloblasts…”
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Regeneration of bone and periodontal ligament induced by recombinant amelogenin after periodontitis by Haze, Amir, Taylor, Angela L., Haegewald, Stefan, Leiser, Yoav, Shay, Boaz, Rosenfeld, Eli, Gruenbaum‐Cohen, Yael, Dafni, Leah, Zimmermann, Bernd, Heikinheimo, Kristiina, Gibson, Carolyn W., Fisher, Larry W., Young, Marian F., Blumenfeld, Anat, Bernimoulin, Jean P., Deutsch, Dan

“…Regeneration of mineralized tissues affected by chronic diseases comprises a major scientific and clinical challenge. Periodontitis, one such prevalent…”
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Mouse genetic background influences the dental phenotype by Li, Yong, Konicki, William S, Wright, J Timothy, Suggs, Cynthia, Xue, Hui, Kuehl, Melissa A, Kulkarni, Ashok B, Gibson, Carolyn W

“…Dental enamel covers the crown of the vertebrate tooth and is considered to be the hardest tissue in the body. Enamel develops during secretion of an…”
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Partial Rescue of the Amelogenin Null Dental Enamel Phenotype by Li, Yong, Suggs, Cynthia, Wright, J. Timothy, Yuan, Zhi-an, Aragon, Melissa, Fong, Hanson, Simmons, Darrin, Daly, Bill, Golub, Ellis E., Harrison, Gerald, Kulkarni, Ashok B., Gibson, Carolyn W.

“…The amelogenins are the most abundant secreted proteins in developing dental enamel. Enamel from amelogenin (Amelx) null mice is hypoplastic and disorganized,…”
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Leucine‐Rich Amelogenin Peptide: A Candidate Signaling Molecule During Cementogenesis by Boabaid, Fernanda, Gibson, Carolyn W., Kuehl, Melissa A., Berry, Janice E., Snead, Malcolm L., Nociti, Francisco H., Katchburian, Eduardo, Somerman, Martha J.

“…Background: Cementum is a critical mineralized tissue; however, control of its formation remains undefined. One hypothesis is that enamel matrix…”
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Dental enamel structure is altered by expression of dominant negative RhoA in ameloblasts by Li, Yong, Pugach, Megan K, Kuehl, Melissa A, Peng, Li, Bouchard, Jessica, Hwang, Soon Y, Gibson, Carolyn W

“…Using in vitrotooth germ cultures and analysis by confocal microscopy, ameloblasts treated with sodium fluoride were found to have elevated amounts of…”
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Amelogenin: A Potential Regulator of Cementum‐Associated Genes by Viswanathan, Hema L., Berry, Janice E., Foster, Brian L., Gibson, Carolyn W., Li, Yong, Kulkarni, Ashok B., Snead, Malcolm L., Somerman, Martha J.

“…Background: Studies suggest that enamel matrix proteins induce differentiation and mineralization of a variety of mesenchymal cells, including odontoblasts,…”
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A developmental comparison of matrix metalloproteinase-20 and amelogenin null mouse enamel by Bartlett, John D., Skobe, Ziedonis, Lee, Daniel H., Wright, J. Timothy, Li, Yong, Kulkarni, Ashok B., Gibson, Carolyn W.

“…Mutations in both the human amelogenin and human matrix metalloproteinase‐20 (MMP20, enamelysin) genes cause amelogenesis imperfecta. Both genes have also been…”
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Amelogenin X impacts age-dependent increase of frequency and number in labial incisor grooves in C57BL/6 by Ota, Masato S., Kondo, Kaori, Li, Yong, Iseki, Sachiko, Yamashita, Atsuko, Gibson, Carolyn W., Kondo, Takashi

“…Labial grooves in maxillary incisors have been reported in several wild-type rodent species. Previous studies have reported age-dependent labial grooves occur…”
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Comparison of body weight and gene expression in amelogenin null and wild-type mice by Li, Yong, Yuan, Zhi-An, Aragon, Melissa A., Kulkarni, Ashok B., Gibson, Carolyn W.

“…Amelogenin (AmelX) null mice develop hypomineralized enamel lacking normal prism structure, but are healthy and fertile. Because these mice are smaller than…”
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Effects of sodium fluoride on the actin cytoskeleton of murine ameloblasts by Li, Yong, Decker, Sylvia, Yuan, Zhi-an, DenBesten, Pamela K., Aragon, Melissa A., Jordan-Sciutto, Kelly, Abrams, William R., Huh, Jung, McDonald, Celeste, Chen, Enhong, MacDougall, Mary, Gibson, Carolyn W.

“…Fluoride is associated with a decrease in the incidence of dental caries, but excess fluoride can lead to enamel fluorosis, a defect that occurs during tooth…”
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The Amelogenin Proteins and Enamel Development in Humans and Mice by Gibson, Carolyn W.

“…Before a tooth erupts into the oral cavity, the mineralized enamel and dentin layers begin to develop. During these early stages of enamel formation, an…”
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Wnt-RhoA signaling pathways in fluoride-treated ameloblast-lineage cells by Shusterman, Kate, Gibson, Carolyn W, Li, Yong, Healey, Melissa, Peng, Li

“…This study examined the effect of sodium fluoride (NaF) on the Wnt and RhoA signaling pathways in murine ameloblast-lineage cells (ALCs) to better understand…”
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