Search Results - "Gibo, Denise"

New agents for targeting of IL-13RA2 expressed in primary human and canine brain tumors by Debinski, Waldemar, Dickinson, Peter, Rossmeisl, John H, Robertson, John, Gibo, Denise M

“…Interleukin 13 receptor alpha 2 (IL-13RA2) is over-expressed in a vast majority of human patients with high-grade astrocytomas like glioblastoma. Spontaneous…”
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An interleukin 13 receptor α 2-specific peptide homes to human Glioblastoma multiforme xenografts by Pandya, Hetal, Gibo, Denise M., Garg, Shivank, Kridel, Steven, Debinski, Waldemar

“…Interleukin 13 receptor α 2 (IL-13Rα2) is a glioblastoma multiforme (GBM)-associated plasma membrane receptor, a brain tumor of dismal prognosis. Here, we…”
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EphA2 as a Novel Molecular Marker and Target in Glioblastoma Multiforme by Wykosky, Jill, Gibo, Denise M, Stanton, Constance, Debinski, Waldemar

“…We investigated the presence of EphA2, and its ligand, ephrinA1, in glioblastoma multiforme (GBM), a malignant neoplasm of glial cells, and normal brain. We…”
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A novel, potent, and specific ephrinA1-based cytotoxin against EphA2 receptor–expressing tumor cells by Wykosky, Jill, Gibo, Denise M, Debinski, Waldemar

“…We have previously shown that the EphA2 receptor tyrosine kinase is overexpressed in glioblastoma multiforme (GBM) and represents a novel, attractive…”
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Interleukin-13 receptor alpha 2, EphA2, and Fos-related antigen 1 as molecular denominators of high-grade astrocytomas and specific targets for combinatorial therapy by Wykosky, Jill, Gibo, Denise M, Stanton, Constance, Debinski, Waldemar

“…We investigated the expression of interleukin-13 receptor alpha2 (IL-13R alpha 2), EphA2, and Fos-related antigen 1 (Fra-1) in astrocytomas and normal brain…”
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EphrinA1 Is Released in Three Forms from Cancer Cells by Matrix Metalloproteases by Beauchamp, Amanda, Lively, Mark O., Mintz, Akiva, Gibo, Denise, Wykosky, Jill, Debinski, Waldemar

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Fos-Related Antigen 1 Modulates Malignant Features of Glioma Cells by Debinski, Waldemar, Gibo, Denise M

“…Malignant gliomas, and high-grade gliomas (HGG) in particular, are nonmetastasizing but locally infiltrating, hypervascularized brain tumors of poor prognosis…”
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Fos-related antigen 1 (Fra-1) pairing with and transactivation of JunB in GBM cells by Debinski, Waldemar, Gibo, Denise M.

“…Fos-related antigen 1 (Fra-1) plays an important role in maintenance/progression of various cancers, including glioblastoma multiforme (GBM). In this study, we…”
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Frame-Based Stereotactic Biopsy of Canine Brain Masses: Technique and Clinical Results in 26 Cases by Rossmeisl, John Henry, Andriani, Rudy T, Cecere, Thomas E, Lahmers, Kevin, LeRoith, Tanya, Zimmerman, Kurt L, Gibo, Denise, Debinski, Waldemar

“…This report describes the methodology, diagnostic yield, and adverse events (AE) associated with frame-based stereotactic brain biopsies (FBSB) obtained from…”
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Interleukin-13 Receptor α2, EphA2, and Fos-Related Antigen 1 as Molecular Denominators of High-Grade Astrocytomas and Specific Targets for Combinatorial Therapy by Wykosky, Jill, Gibo, Denise M., Stanton, Constance, Debinski, Waldemar

“…Purpose: We investigated the expression of interleukin-13 receptor α2 (IL-13Rα2), EphA2, and Fos-related antigen 1 (Fra-1) in astrocytomas and normal brain. We…”
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Reoxygenation of Hypoxic Glioblastoma Multiforme Cells Potentiates the Killing Effect of an Interleukin-13-Based Cytotoxin by Liu, Tie Fu, Cai, Jiaozhong, Gibo, Denise M, Debinski, Waldemar

“…Purpose: Hypoxia is a cause for resistance to cancer therapies. Molecularly targeted recombinant cytotoxins have shown clinical efficacy in the treatment of…”
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A novel ligand delivery system to non-invasively visualize and therapeutically exploit the IL13Rα2 tumor-restricted biomarker by Nguyen, Van, Conyers, Jesse M, Zhu, Dongqin, Gibo, Denise M, Hantgan, Roy R, Larson, Steven M, Debinski, Waldemar, Mintz, Akiva

“…Our objective was to exploit a novel ligand-based delivery system for targeting diagnostic and therapeutic agents to cancers that express interleukin 13…”
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IL-13Rα2-Targeted Therapy Escapees: Biologic and Therapeutic Implications by Nguyen, Van, Conyers, Jesse M, Zhu, Dongqin, Gibo, Denise M, Dorsey, Jay F, Debinski, Waldemar, Mintz, Akiva

“…Abstract Glioblastoma multiforme (GBM) overexpresses interleukin 13 receptor α2 (IL-13Rα2), a tumor-restricted receptor that is not present in normal brain. We…”
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Molecular targeting of intracellular compartments specifically in cancer cells by Pandya, Hetal, Gibo, Denise M, Debinski, Waldemar

“…We have implemented a strategy in which a genetically engineered, single-chain protein specifically recognizes cancer cells and is trafficked to a targeted…”
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Protein- and DNA-based active immunotherapy targeting interleukin-13 receptor alpha2 by Mintz, Akiva, Gibo, Denise M, Madhankumar, A B, Cladel, Nancy M, Christensen, Neil D, Debinski, Waldemar

“…High-grade astrocytoma (HGA) is an invariably fatal malignancy with a mean survival of 14 months despite surgery, radiation, and chemotherapy. We have found…”
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Novel anti-brain tumor cytotoxins specific for cancer cells by Debinski, Waldemar, Gibo, Denise M, Obiri, Nicholas I, Kealiher, Aynsley, Puri, Raj K

“…The vast majority of brain cancers (gliomas) express a receptor (R) for interleukin 13 (IL13). In order to achieve specific targeting of the IL13R in gliomas,…”
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Receptor for Interleukin 13 Is a Marker and Therapeutic Target for Human High-Grade Gliomas by Debinski, W, Gibo, D M, Hulet, S W, Connor, J R, Gillespie, G Y

“…Glioblastoma multiforme (GBM) is an incurable brain tumor. Due to the striking heterogeneity that characterizes GBM, there is no known tumor-specific antigen…”
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IL-13Rα2 is a Glioma-Restricted Receptor for Interleukin-13 by Mintz, Akiva, Gibo, Denise M., Slagle-Webb, Becky, Christensent, Neil D., Debinski, Waldemar

“…We have found that binding sites for interleukin-13. ( IL13) are overexpressed in a vast majority of high-grade astrocytomas. (HGAs). These binding sites for…”
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Molecular expression analysis of restrictive receptor for interleukin 13, a brain tumor-associated cancer/testis antigen by Debinski, W, Gibo, D M

“…The vast majority of patients with high-grade gliomas (HGG) over-express interleukin 4 (IL4)-independent binding sites for IL13 in situ. In addition, mutated…”
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BI-09EphA3 RECEPTOR IS A MOLECULAR TARGET EXPRESSED IN MULTIPLE COMPARTMENTS OF GBM by Ferluga, Sara, Gibo, Denise, Debinski, Waldemar

“…Eph receptor A3 belongs to the Eph family of receptor tyrosine kinases playing critical roles in cancer. We and others found this receptor to be over-expressed…”
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