Search Results - "Gibney, G. T."

Beyond BRAF: where next for melanoma therapy? by Fedorenko, I V, Gibney, G T, Sondak, V K, Smalley, K S M

“…In recent years, melanoma has become a poster-child for the development of oncogene-directed targeted therapies. This approach, which has been exemplified by…”
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c-Met is a prognostic marker and potential therapeutic target in clear cell renal cell carcinoma by Gibney, G.T., Aziz, S.A., Camp, R.L., Conrad, P., Schwartz, B.E., Chen, C.R., Kelly, W.K., Kluger, H.M.

“…Activation of the c-Met pathway occurs in a range of malignancies, including papillary renal cell carcinoma (RCC). Its activity in clear cell RCC is less…”
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Clinical outcomes of melanoma brain metastases treated with stereotactic radiation and anti-PD-1 therapy by Ahmed, K.A., Stallworth, D.G., Kim, Y., Johnstone, P.A.S., Harrison, L.B., Caudell, J.J., Yu, H.H.M., Etame, A.B., Weber, J.S., Gibney, G.T.

“…The anti-programmed death-1 (anti-PD-1) therapy nivolumab has significant clinical activity in patients with metastatic melanoma. However, little is known…”
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Meeting report from the Society for Melanoma Research 2012 Congress, Hollywood, California by Lo, R. S., Ribas, A., Long, G. V., Ballotti, R., Berger, M., Willy, H., Gibney, G. T., Bosenberg, M., Bernstein, E., Villanueva, J., Smalley, K. S. M.

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NRAS mutant melanoma: biological behavior and future strategies for therapeutic management by Fedorenko, I V, Gibney, G T, Smalley, K S M

“…The recent years have seen a significant shift in the expectations for the therapeutic management of disseminated melanoma. The clinical success of BRAF…”
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Fibronectin induction abrogates the BRAF inhibitor response of BRAF V600E/PTEN-null melanoma cells by Fedorenko, I V, Abel, E V, Koomen, J M, Fang, B, Wood, E R, Chen, Y A, Fisher, K J, Iyengar, S, Dahlman, K B, Wargo, J A, Flaherty, K T, Sosman, J A, Sondak, V K, Messina, J L, Gibney, G T, Smalley, K S M

“…The mechanisms by which some melanoma cells adapt to Serine/threonine-protein kinase B-Raf (BRAF) inhibitor therapy are incompletely understood. In the present…”
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Clinical outcome of immune related hepatitis (IrHep) in patients with advanced melanoma (AM) treated with single agent or combination immune checkpoint inhibitors (ICIs) by Shah, N., Puthiamadathil, J., Serzan, M.T., Belouali, A., Kelly, W.J., MA, B., blackburn, M., Knoedler, A., OchoaGonzaelz, S., Janni, M., Madhavan, S., Gibney, G.T., Atkins, M.B.

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Effect of prolonged hypoxia on Na + channel mRNA subtypes in the developing rat cortex by Zhang, J.H, Gibney, G.T, Xia, Y

“…Voltage-gated Na + channels are regulated in response to oxygen deprivation in the mammalian cortex. Past investigations have demonstrated that Na + channel…”
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Na(+)/Ca(2+) exchanger expression in the developing rat cortex by Gibney, G T, Zhang, J H, Douglas, R M, Haddad, G G, Xia, Y

“…The Na(+)/Ca(2+) exchanger (NCX) participates in the regulation of neuronal Ca(2+) homeostasis and is also believed to be involved in the neuronal responses to…”
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Effect of protein kinases on lactate dehydrogenase activity in cortical neurons during hypoxia by Hong, Soon-Sun, Gibney, Geoffrey T, Esquilin, Manny, Yu, Jessica, Xia, Ying

“…Our previous work shows that delta-opioid receptor (DOR) protects cortical neurons from hypoxic insults. Since an enhanced anaerobic capacity is important for…”
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Na+/Ca2+ exchanger expression in the developing rat cortex by GIBNEY, G. T, ZHANG, J. H, DOUGLAS, R. M, HADDAD, G. G, XIA, Y

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1222PClinical outcome of immune related hepatitis (IrHep) in patients with advanced melanoma (AM) treated with single agent or combination immune checkpoint inhibitors (ICIs) by Shah, N, Puthiamadathil, J, Serzan, M T, Belouali, A, Kelly, W J, MA, B, blackburn, M, Knoedler, A, OchoaGonzaelz, S, Janni, M, Madhavan, S, Gibney, G T, Atkins, M B

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Safety of the natural killer (NK) cell-targeted anti-KIR antibody, lirilumab (liri), in combination with nivolumab (nivo) or ipilimumab (ipi) in two phase 1 studies in advanced refractory solid tumors by Segal, N.H., Infante, J.R., Sanborn, R.E., Gibney, G.T., Lawrence, D.P., Rizvi, N., Leidner, R., Gajewski, T.F., Bertino, E., Sharfman, W.H., Cooley, S., Topalian, S.L., Urba, W.J., Wolchok, J.D., Gu, X., Passey, C., McDonald, D., Aanur, P., Srivastava, S., Hodi, F.S.

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Meeting report from the S ociety for M elanoma R esearch 2012 C ongress, H ollywood, C alifornia by Lo, R. S., Ribas, A., Long, G. V., Ballotti, R., Berger, M., Willy, H., Gibney, G. T., Bosenberg, M., Bernstein, E., Villanueva, J., Smalley, K. S. M.

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c-Met is a prognostic marker and potential therapeutic target in clear cell renal cell carcinoma by Gibney, G T, Aziz, S A, Camp, R L, Conrad, P, Schwartz, B E, Chen, C R, Kelly, W K, Kluger, H M

“…Activation of the c-Met pathway occurs in a range of malignancies, including papillary renal cell carcinoma (RCC). Its activity in clear cell RCC is less…”
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Neuroprotective role of delta-opioid receptors in cortical neurons by Zhang, Junhui, Gibney, Geoffrey Thomas, Zhao, Peng, Xia, Ying

“…We recently demonstrated that delta-opioid receptor (DOR) activation protects cortical neurons against glutamate-induced injury. Because glutamate is a…”
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Na super(+)/Ca super(2+) exchanger expression in the developing rat cortex by Gibney, G T, Zhang, J H, Douglas, R M, Haddad, G G, Xia, Y

“…The Na super(+)/Ca super(2+) exchanger (NCX) participates in the regulation of neuronal Ca super(2+) homeostasis and is also believed to be involved in the…”
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Effect of prolonged hypoxia on Na super(+) channel mRNA subtypes in the developing rat cortex by Zhang, J H, Gibney, G T, Xia, Y

“…Voltage-gated Na super(+) channels are regulated in response to oxygen deprivation in the mammalian cortex. Past investigations have demonstrated that Na…”
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