Search Results - "Giblin, Patricia A."

The determination and correlation of molecular and cellular equilibrium Kd and kinetic koff values for small molecule allosteric antagonists of LFA-1 by CAUINESS, Gary O, LABADIA, Mark E, GIBLIN, Patricia A, WOSKA, Joseph R, LAST-BARNEY, Kathleen, JEANFAVRE, Deborah D, MORELOCK, Maurice M

Get full text

Small molecule LFA-1 antagonists compete with an anti-LFA-1 monoclonal antibody for binding to the CD11a I domain: development of a flow-cytometry-based receptor occupancy assay by Woska, Joseph R., Last-Barney, Kathleen, Rothlein, Robert, Kroe, Rachel R., Reilly, Patricia L., Jeanfavre, Deborah D., Mainolfi, Elizabeth A., Kelly, Terence A., Caviness, Gary O., Fogal, Steven E., Panzenbeck, Maret J., Kishimoto, Takashi K., Giblin, Patricia A.

“…The β 2 integrin LFA-1 (CD11a/CD18) is a leukocyte-specific adhesion molecule that mediates leukocyte extravasation, antigen presentation, and T-cell-mediated…”
Get full text

Chapter 18 . Antagonists of 02 integrin-mediated cell adhesion by Giblin, Patricia A., Kelly, Terence A.

“…The biology of the β2 integrins suggests that they could be attractive targets for the intervention in autoimmune and inflammatory diseases. In the short term,…”
Get full text

The determination and correlation of molecular and cellular equilibrium Kd and kinetic k(off) values for small molecule allosteric antagonists of LFA-1 by Caviness, Gary O, Labadia, Mark E, Giblin, Patricia A, Woska, Jr, Joseph R, Last-Barney, Kathleen, Jeanfavre, Deborah D, Morelock, Maurice M

“…Molecular K(d) and k(off) parameters are often used to define the molecular potency of drugs. These constants, however, are determined on purified target…”
Get full text

The determination and correlation of molecular and cellular equilibrium K d and kinetic k off values for small molecule allosteric antagonists of LFA-1 by Caviness, Gary O., Labadia, Mark E., Giblin, Patricia A., Woska, Joseph R., Last-Barney, Kathleen, Jeanfavre, Deborah D., Morelock, Maurice M.

“…Molecular K d and k off parameters are often used to define the molecular potency of drugs. These constants, however, are determined on purified target…”
Get full text

Factors that contribute to the transneuronal spread of herpes simplex virus by LaVail, Jennifer H., Topp, Kimberly S., Giblin, Patricia A., Garner, Judy A.

“…In viral encephalitis and retinal necrosis, different herpes simplex virus (HSV) strains spread between neurons in the central nervous system (CNS) by…”
Get full text

The Role of Charge and Multiple Faces of the CD8α/α Homodimer in Binding to Major Histocompatibility Complex Class I Molecules: Support for a Bivalent Model by Giblin, Patricia A., Leahy, Daniel J., Mennone, John, Kavathas, Paula B.

“…The CD8 dimer interacts with the α 3 domain of major histocompatibility complex class I molecules through two immunoglobulin variable-like domains. In this…”
Get full text

The role of charge and multiple faces of the CD8(alpha)/(alpha) homodimer in binding to major histocompatibility complex class I molecules: Support for a bivalent model by Giblin, Patricia A, Leahy, Daniel J, Mennone, John, Kavathas, Paula B

“…A crystal structure-informed mutational analysis has been performed to identify amino acids in the CD8alpha/alpha homodimer that are likely to be involved in…”
Get full text