Search Results - "Gibbs, Susan"

The Keloid Disorder: Heterogeneity, Histopathology, Mechanisms and Models by Limandjaja, Grace C, Niessen, Frank B, Scheper, Rik J, Gibbs, Susan

“…Keloids constitute an abnormal fibroproliferative wound healing response in which raised scar tissue grows excessively and invasively beyond the original wound…”
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Stimulation of oral fibroblast chemokine receptors identifies CCR3 and CCR4 as potential wound healing targets by Buskermolen, Jeroen K., Roffel, Sanne, Gibbs, Susan

“…The focus of this study was to determine which chemokine receptors are present on oral fibroblasts and whether these receptors influence proliferation,…”
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Editorial: New approach methods in immunology by Hartung, Thomas, Bajramovic, Jeffrey John, Gibbs, Susan, Corsini, Emanuela

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Multi-species oral biofilm promotes reconstructed human gingiva epithelial barrier function by Shang, Lin, Deng, Dongmei, Buskermolen, Jeroen Kees, Janus, Marleen Marga, Krom, Bastiaan Philip, Roffel, Sanne, Waaijman, Taco, van Loveren, Cor, Crielaard, Wim, Gibbs, Susan

“…Since the oral mucosa is continuously exposed to abundant microbes, one of its most important defense features is a highly proliferative, thick, stratified…”
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The Bigger Picture: Why Oral Mucosa Heals Better Than Skin by Waasdorp, Maaike, Krom, Bastiaan P., Bikker, Floris J., van Zuijlen, Paul P. M., Niessen, Frank B., Gibbs, Susan

“…Wound healing is an essential process to restore tissue integrity after trauma. Large skin wounds such as burns often heal with hypertrophic scarring and…”
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Sensing of latent EBV infection through exosomal transfer of 5′pppRNA by Baglio, S. Rubina, van Eijndhoven, Monique A. J., Koppers-Lalic, Danijela, Berenguer, Jordi, Lougheed, Sinéad M., Gibbs, Susan, Léveillé, Nicolas, Rinkel, Rico N. P. M., Hopmans, Erik S., Swaminathan, Sankar, Verkuijlen, Sandra A. W. M., Scheffer, George L., van Kuppeveld, Frank J. M., de Gruijl, Tanja D., Bultink, Irene E. M., Jordanova, Ekaterina S., Hackenberg, Michael, Piersma, Sander R., Knol, Jaco C., Voskuyl, Alexandre E., Wurdinger, Thomas, Jiménez, Connie R., Middeldorp, Jaap M., Pegtel, D. Michiel

“…Complex interactions between DNA herpesviruses and host factors determine the establishment of a life-long asymptomatic latent infection. The lymphotropic…”
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In vitro immunity: an overview of immunocompetent organ-on-chip models by Morrison, Andrew I, Sjoerds, Mirthe J, Vonk, Leander A, Gibbs, Susan, Koning, Jasper J

“…Impressive advances have been made to replicate human physiology over the last few years due to the growth of the organ-on-chip (OoC) field in both industrial…”
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hTERT-immortalized gingival fibroblasts respond to cytokines but fail to mimic primary cell responses to Porphyromonas gingivalis by Lagosz-Cwik, Katarzyna B., Wielento, Aleksandra, Lipska, Weronika, Kantorowicz, Malgorzata, Darczuk, Dagmara, Kaczmarzyk, Tomasz, Gibbs, Susan, Potempa, Jan, Grabiec, Aleksander M.

“…In periodontitis, gingival fibroblasts (GFs) interact with and respond to oral pathogens, significantly contributing to perpetuation of chronic inflammation…”
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Commensal and Pathogenic Biofilms Alter Toll-Like Receptor Signaling in Reconstructed Human Gingiva by Shang, Lin, Deng, Dongmei, Buskermolen, Jeroen Kees, Roffel, Sanne, Janus, Marleen Marga, Krom, Bastiaan Philip, Crielaard, Wim, Gibbs, Susan

“…The balance between the host and microbe is pivotal for oral health. A dysbiotic oral microbiome and the subsequent host inflammatory response are causes for…”
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Intralesional corticosteroid administration in the treatment of keloids: a survey among Dutch dermatologists and plastic surgeons by Yin, Qi, Niessen, Frank B., Gibbs, Susan, Lapid, Oren, Louter, Juliette M. I., van Zuijlen, Paul P. M., Wolkerstorfer, Albert

“…Intralesional corticosteroid administration (ICA) is a first-line therapy in keloid treatment. However, its clinical results are still highly variable and…”
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Systematic evaluation of non-animal test methods for skin sensitisation safety assessment by Reisinger, Kerstin, Hoffmann, Sebastian, Alépée, Nathalie, Ashikaga, Takao, Barroso, Joao, Elcombe, Cliff, Gellatly, Nicola, Galbiati, Valentina, Gibbs, Susan, Groux, Hervé, Hibatallah, Jalila, Keller, Donald, Kern, Petra, Klaric, Martina, Kolle, Susanne, Kuehnl, Jochen, Lambrechts, Nathalie, Lindstedt, Malin, Millet, Marion, Martinozzi-Teissier, Silvia, Natsch, Andreas, Petersohn, Dirk, Pike, Ian, Sakaguchi, Hitoshi, Schepky, Andreas, Tailhardat, Magalie, Templier, Marie, van Vliet, Erwin, Maxwell, Gavin

“…•Non-animal data for skin sensitisation risk assessment are urgently needed.•This has led to the development of a number of in vitro test methods.•Cosmetics…”
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Reconstructed human skin shows epidermal invagination towards integrated neopapillae indicating early hair follicle formation in vitro by Vahav, Irit, Broek, Lenie J., Thon, Maria, Monsuur, Hanneke N., Spiekstra, Sander W., Atac, Beren, Scheper, Rik J., Lauster, Roland, Lindner, Gerd, Marx, Uwe, Gibbs, Susan

“…Application of reconstructed human Skin (RhS) is a promising approach for the treatment of extensive wounds and for drug efficacy and safety testing. However,…”
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Comparative phenotypic and functional analysis of migratory dendritic cell subsets from human oral mucosa and skin by Kosten, Ilona Jennifer, van de Ven, Rieneke, Thon, Maria, Gibbs, Susan, de Gruijl, Tanja D

“…Antigen exposure to oral mucosa is generally thought to lead to immune tolerance induction. However, very little is known about the subset composition and…”
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Mechanisms of Porphyromonas gingivalis to translocate over the oral mucosa and other tissue barriers by de Jongh, Caroline A., de Vries, Teun J., Bikker, Floris J., Gibbs, Susan, Krom, Bastiaan P.

“…The oral pathogen Porphyromonas gingivalis is not only associated with periodontitis but also with systemic diseases elsewhere in the body. The mechanisms by…”
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Stable reconstructed human gingiva-microbe interaction model: Differential response to commensals and pathogens by Zhang, Yan, Shang, Lin, Roffel, Sanne, Krom, Bastiaan P, Gibbs, Susan, Deng, Dongmei

“…To investigate human oral health and disease, models are required which represent the interactions between the oral mucosa and microbiome. Our aim was to…”
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Autocrine Regulation of Re-Epithelialization After Wounding by Chemokine Receptors CCR1, CCR10, CXCR1, CXCR2, and CXCR3 by Kroeze, Kim L., Boink, Mireille A., Sampat-Sardjoepersad, Shakun C., Waaijman, Taco, Scheper, Rik J., Gibbs, Susan

“…This study identifies chemokine receptors involved in an autocrine regulation of re-epithelialization after skin tissue damage. We determined which receptors,…”
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Wound-healing factors secreted by epidermal keratinocytes and dermal fibroblasts in skin substitutes by Spiekstra, Sander W., Breetveld, Melanie, Rustemeyer, Thomas, Scheper, Rik J., Gibbs, Susan

“…ABSTRACT Full‐skin substitutes, epidermal substitutes, and dermal substitutes are currently being used to heal deep burns and chronic ulcers. In this study, we…”
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Suppressed inflammatory gene expression during human hypertrophic scar compared to normotrophic scar formation by van den Broek, Lenie J., van der Veer, Willem M., de Jong, Etty H., Gibbs, Susan, Niessen, Frank B.

“…Hypertrophic scar formation is a result of adverse cutaneous wound healing. The pathogenesis of hypertrophic scar formation is still poorly understood. A…”
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Different wound healing properties of dermis, adipose, and gingiva mesenchymal stromal cells by Boink, Mireille A., van den Broek, Lenie J., Roffel, Sanne, Nazmi, Kamran, Bolscher, Jan G.M., Gefen, Amit, Veerman, Enno C.I., Gibbs, Susan

“…Oral wounds heal faster and with better scar quality than skin wounds. Deep skin wounds where adipose tissue is exposed, have a greater risk of forming…”
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Extensive Characterization and Comparison of Endothelial Cells Derived from Dermis and Adipose Tissue: Potential Use in Tissue Engineering by Monsuur, Hanneke N, Weijers, Ester M, Niessen, Frank B, Gefen, Amit, Koolwijk, Pieter, Gibbs, Susan, van den Broek, Lenie J

“…Tissue-engineered constructs need to become quickly vascularized in order to ensure graft take. One way of achieving this is to incorporate endothelial cells…”
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