Search Results - "Gibbs, J B"

Mechanism-Based Target Identification and Drug Discovery in Cancer Research by Gibbs, Jackson B.

“…Cancer as a disease in the human population is becoming a larger health problem, and the medicines used as treatments have clear limitations. In the past 20…”
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Sequence dependence of protein isoprenylation by MOORES, S. L, SCHABER, M. D, MOSSER, S. D, RANDS, E, O'HARA, M. B, GARSKY, V. M, MARSHALL, M. S, POMPLIANO, D. L, GIBBS, J. B

“…Several proteins have been shown to be post-translationally modified on a specific C-terminal cysteine residue by either of two isoprenoid biosynthetic pathway…”
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Kinase-deficient Pak1 mutants inhibit Ras transformation of Rat-1 fibroblasts by Tang, Yi, Chen, Zunxuan, Ambrose, Diane, Liu, Jianhua, Gibbs, Jackson B., Chernoff, Jonathan, Field, Jeffrey

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Selective Inhibition of ras-Dependent Transformation by a Farnesyltransferase Inhibitor by Kohl, Nancy E., Mosser, Scott D., deSolms, S. Jane, Giuliani, Elizabeth A., Pompliano, David L., Graham, Samuel L., Smith, Robert L., Scolnick, Edward M., Oliff, Allen, Gibbs, Jackson B.

“…To acquire transforming potential, the precursor of the Ras oncoprotein must undergo farnesylation of the cysteine residue located in a carboxyl-terminal…”
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Protein prenylation in eukaryotic microorganisms: genetics, biology and biochemistry by Omer, C A, Gibbs, J B

“…Modification of proteins at C-terminal cysteine residue(s) by the isoprenoids farnesyl (C15) and geranylgeranyl (C20) is essential for the biological function…”
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Antitumor effect of a farnesyl protein transferase inhibitor in mammary and lymphoid tumors overexpressing N-ras in transgenic mice by MANGUES, R, CORRAL, T, KOHL, N. E, SYMMANS, W. F, SUYING LU, MALUMBRES, M, GIBBS, J. B, OLIFF, A, PELLICER, A

“…We tested the antineoplastic effect of the farnesyltransferase inhibitor L-744,832 in mammary and lymphoid tumors overexpressing the N-ras proto-oncogene in…”
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Selective inhibition of farnesyl-protein transferase blocks ras processing in vivo by GIBBS, J. B, POMPLIANO, D. L, MOSSER, S. D, RANDS, E, LINGHAM, R. B, SHEO BUX SINGH, SCOLNICK, E. M, KOHL, N. E, OLIFF, A

“…The ras oncogene product, Ras, is synthesized in vivo as a precursor protein that requires post-translational processing to become biologically active and to…”
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The ras oncogene: an important regulatory element in lower eucaryotic organisms by GIBBS, J. B, MARSHALL, M. S

“…The ras proto-oncogene in mammalian cells encodes a 21-kilodalton guanosine triphosphate (GTP)-binding protein. This gene is frequently activated in human…”
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In vitro and In vivo effects of a farnesyltransferase inhibitor on Nf1-deficient hematopoietic cells by MAHGOUB, N, TAYLOR, B. R, GRATIOT, M, KOHL, N. E, GIBBS, J. B, JACKS, T, SHANNON, K. M

“…Oncogenic RAS alleles encode proteins that accumulate in the guanosine triphosphate (GTP)-bound state. Because post-translational processing of Ras by…”
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Farnesyltransferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of the actin cytoskeleton by Prendergast, G C, Davide, J P, deSolms, S J, Giuliani, E A, Graham, S L, Gibbs, J B, Oliff, A, Kohl, N E

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Identification of Effector Residues and a Neutralizing Epitope of Ha-ras-Encoded p21 by Sigal, Irving S., Gibbs, Jackson B., D'Alonzo, Jill S., Scolnick, Edward M.

“…To identify the amino acid residues of the Harvey (Ha) ras-encoded protein that are involved in protein-protein interactions, we have created a series of…”
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cDNA cloning and expression of rat and human protein geranylgeranyltransferase type-I by ZHANG, F. L, DIEHL, R. E, KOHL, N. E, GIBBS, J. B, GIROS, B, CASEY, P. J, OMER, C. A

“…Protein geranylgeranyltransferase type-I (GGTase-I) transfers a geranylgeranyl group to the cysteine residue of candidate proteins containing a…”
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Farnesyltransferase Inhibitors Potentiate the Antitumor Effect of Radiation on a Human Tumor Xenograft Expressing Activated HRAS by Cohen-Jonathan, Elizabeth, Muschel, Ruth J., McKenna, W. Gillies, Evans, Sydney M., Cerniglia, George, Mick, Rosemarie, Kusewitt, Donna, Sebti, Said M., Hamilton, Andrew D., Oliff, Allen, Kohl, Nancy, Gibbs, Jackson B., Bernhard, Eric J.

“…Successful radiosensitization requires that tumor cells become more radiosensitive without causing an equivalent reduction in the survival of cells of the…”
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Modulation of guanine nucleotides bound to Ras in NIH3T3 cells by oncogenes, growth factors, and the GTPase activating protein (GAP) by Gibbs, J B, Marshall, M S, Scolnick, E M, Dixon, R A, Vogel, U S

“…The mitogenic activity of membrane-associated tyrosine kinases such as Src and the PDGF receptor appear to depend on Ras function. Ras biochemical activity…”
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Intrinsic GTPase Activity Distinguishes Normal and Oncogenic ras p21 Molecules by Gibbs, Jackson B., Sigal, Irving S., Poe, Martin, Scolnick, Edward M.

“…The 21-kilodalton protein (p21) encoded by normal cellular Harvey-ras has been expressed in Escherichia coli as a fusion protein by using the pUC8 vector and…”
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PDGF induction of tyrosine phosphorylation of GTPase activating protein by Molloy, Christopher J, Bottaro, Donald P, Fleming, Timothy P, Marshall, Mark S, Gibbs, Jackson B, Aaronson, Stuart A

“…The cascade of biochemical events triggered by growth factors and their receptors is central to understanding normal cell-growth regulation and its subversion…”
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Steady-state kinetic mechanism of ras farnesyl:protein transferase by Pompliano, David L, Rands, Elaine, Schaber, Michael D, Mosser, Scott D, Anthony, Neville J, Gibbs, Jackson B

“…The steady-state kinetic mechanism of bovine brain farnesyl:protein transferase (FPTase) has been determined using a series of initial velocity studies,…”
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Purification of ras GTPase activating protein from bovine brain by Gibbs, J.B, Schaber, M.D, Allard, W.J, Sigal, I.S, Scolnick, E.M

“…In cytosolic extracts of bovine brain, we detected ras GTPase activating protein (GAP) activity that stimulated the GTP hydrolytic activity of normal c-Ha-ras…”
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Imidazole-containing diarylether and diarylsulfone inhibitors of farnesyl-protein transferase by Dinsmore, Christopher J., Williams, Theresa M., O'Neill, Timothy J., Liu, Dongming, Rands, Elaine, Culberson, J.Christopher, Lobell, Robert B., Koblan, Kenneth S., Kohl, Nancy E., Gibbs, Jackson B., Oliff, Allen I., Graham, Samuel L., Hartman, George D.

“…The design and syntheses of non-thiol inhibitors of farnesyl-protein transferase are described. Optimization of cysteine-substituted diarylethers led to highly…”
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Anticancer drug targets: growth factors and growth factor signaling by Gibbs, J B

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