Search Results - "Gibbs, Eric"

Application of NMR to studies of intrinsically disordered proteins by Gibbs, Eric B., Cook, Erik C., Showalter, Scott A.

“…The prevalence of intrinsically disordered protein regions, particularly in eukaryotic proteins, and their clear functional advantages for signaling and gene…”
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Methods for Physical Characterization of Phase-Separated Bodies and Membrane-less Organelles by Mitrea, Diana M., Chandra, Bappaditya, Ferrolino, Mylene C., Gibbs, Eric B., Tolbert, Michele, White, Michael R., Kriwacki, Richard W.

“…Membrane-less organelles are cellular structures which arise through the phenomenon of phase separation. This process enables compartmentalization of specific…”
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Quantitative Biophysical Characterization of Intrinsically Disordered Proteins by Gibbs, Eric B, Showalter, Scott A

“…Intrinsically disordered proteins (IDPs) are broadly defined as protein regions that do not cooperatively fold into a spatially or temporally stable structure…”
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Phosphorylation induces sequence-specific conformational switches in the RNA polymerase II C-terminal domain by Gibbs, Eric B., Lu, Feiyue, Portz, Bede, Fisher, Michael J., Medellin, Brenda P., Laremore, Tatiana N., Zhang, Yan Jessie, Gilmour, David S., Showalter, Scott A.

“…The carboxy-terminal domain (CTD) of the RNA polymerase II (Pol II) large subunit cycles through phosphorylation states that correlate with progression through…”
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Conformational transitions and allosteric modulation in a heteromeric glycine receptor by Gibbs, Eric, Klemm, Emily, Seiferth, David, Kumar, Arvind, Ilca, Serban L., Biggin, Philip C., Chakrapani, Sudha

“…Glycine Receptors (GlyRs) provide inhibitory neuronal input in the spinal cord and brainstem, which is critical for muscle coordination and sensory perception…”
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Structural heterogeneity in the intrinsically disordered RNA polymerase II C-terminal domain by Portz, Bede, Lu, Feiyue, Gibbs, Eric B., Mayfield, Joshua E., Rachel Mehaffey, M., Zhang, Yan Jessie, Brodbelt, Jennifer S., Showalter, Scott A., Gilmour, David S.

“…RNA polymerase II contains a repetitive, intrinsically disordered, C-terminal domain (CTD) composed of heptads of the consensus sequence YSPTSPS. The CTD is…”
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High-resolution structures of multiple 5-HT3AR-setron complexes reveal a novel mechanism of competitive inhibition by Basak, Sandip, Kumar, Arvind, Ramsey, Steven, Gibbs, Eric, Kapoor, Abhijeet, Filizola, Marta, Chakrapani, Sudha

“…Serotonin receptors (5-HT 3A R) play a crucial role in regulating gut movement, and are the principal target of setrons, a class of high-affinity competitive…”
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p14ARF forms meso-scale assemblies upon phase separation with NPM1 by Gibbs, Eric, Miao, Qi, Ferrolino, Mylene, Bajpai, Richa, Hassan, Aila, Phillips, Aaron H., Pitre, Aaron, Kümmerle, Rainer, Miller, Shondra, Nagy, Gergely, Leite, Wellington, Heller, William, Stanley, Chris, Perrone, Barbara, Kriwacki, Richard

“…NPM1 is an abundant nucleolar chaperone that, in addition to facilitating ribosome biogenesis, contributes to nucleolar stress responses and tumor suppression…”
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Quantification of Compactness and Local Order in the Ensemble of the Intrinsically Disordered Protein FCP1 by Gibbs, Eric B, Showalter, Scott A

“…Intrinsically disordered protein regions (IDRs) partially or completely lack a cooperatively folded structure under native conditions, preventing their…”
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Joint 2D and 3D phase processing for quantitative susceptibility mapping: application to 2D echo‐planar imaging by Wei, Hongjiang, Zhang, Yuyao, Gibbs, Eric, Chen, Nan‐Kuei, Wang, Nian, Liu, Chunlei

“…Quantitative susceptibility mapping (QSM) measures tissue magnetic susceptibility and typically relies on time‐consuming three‐dimensional (3D) gradient‐echo…”
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Temperature-activated ion channels in neural crest cells confer maternal fever-associated birth defects by Hutson, Mary R, Keyte, Anna L, Hernández-Morales, Miriam, Gibbs, Eric, Kupchinsky, Zachary A, Argyridis, Ioannis, Erwin, Kyle N, Pegram, Kelly, Kneifel, Margaret, Rosenberg, Paul B, Matak, Pavle, Xie, Luke, Grandl, Jörg, Davis, Erica E, Katsanis, Nicholas, Liu, Chunlei, Benner, Eric J

“…Birth defects of the heart and face are common, and most have no known genetic cause, suggesting a role for environmental factors. Maternal fever during the…”
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Linker histones as liquid-like glue for chromatin by Gibbs, Eric B., Kriwack, Richard W.

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Abilifright: A Case Report of Massive Aripiprazole Overdose in a Toddler by Warstadt, Nicholus M, Mohan, Sanjay, Furlano, Emma R, Shenker, Jennifer H, Gibbs, Eric P, Smith, Silas W

“…Aripiprazole is an atypical antipsychotic with unique receptor-binding properties that has a favorable safety profile in therapeutic doses compared to other…”
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Substrate Specificity of the Kinase P-TEFb towards the RNA Polymerase II C-Terminal Domain by Gibbs, Eric B., Laremore, Tatiana N., Usher, Grace A., Portz, Bede, Cook, Erik C., Showalter, Scott A.

“…The positive transcription elongation factor b (P-TEFb) promotes transcription elongation through phosphorylation of the RNA polymerase II C-terminal domain…”
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Gene Therapy for Osteoarthritis: Pharmacokinetics of Intra-Articular Self-Complementary Adeno-Associated Virus Interleukin-1 Receptor Antagonist Delivery in an Equine Model by Watson Levings, Rachael S, Broome, Ted A, Smith, Andrew D, Rice, Brett L, Gibbs, Eric P, Myara, David A, Hyddmark, E Viktoria, Nasri, Elham, Zarezadeh, Ali, Levings, Padraic P, Lu, Yuan, White, Margaret E, Dacanay, E Anthony, Foremny, Gregory B, Evans, Christopher H, Morton, Alison J, Winter, Mathew, Dark, Michael J, Nickerson, David M, Colahan, Patrick T, Ghivizzani, Steven C

“…Toward the treatment of osteoarthritis (OA), the authors have been investigating self-complementary adeno-associated virus (scAAV) for intra-articular delivery…”
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Self-Complementary Adeno-Associated Virus-Mediated Interleukin-1 Receptor Antagonist Gene Delivery for the Treatment of Osteoarthritis: Test of Efficacy in an Equine Model by Watson Levings, Rachael S, Smith, Andrew D, Broome, Ted A, Rice, Brett L, Gibbs, Eric P, Myara, David A, Hyddmark, E Viktoria, Nasri, Elham, Zarezadeh, Ali, Levings, Padraic P, Lu, Yuan, White, Margaret E, Dacanay, E Anthony, Foremny, Gregory B, Evans, Christopher H, Morton, Alison J, Winter, Mathew, Dark, Michael J, Nickerson, David M, Colahan, Patrick T, Ghivizzani, Steven C

“…The authors are investigating self-complementary adeno-associated virus (scAAV) as a vector for intra-articular gene-delivery of interleukin-1 receptor…”
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Structure, Function and Physiology of 5-Hydroxytryptamine Receptors Subtype 3 by Gibbs, Eric, Chakrapani, Sudha

“…5-hydroxytryptamine receptor subtype 3 (5-HT R) is a pentameric ligand-gated ion channel (pLGIC) involved in neuronal signaling. It is best known for its…”
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Investigating the Structural Basis of the CTD Code by Gibbs, Eric, Showalter, Scott

“…Abstract only The goal of this project is to study the structure and function of the C‐terminal domain of RNA Polymerase II (CTD). The CTD, which contains…”
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Linker histones as liquid-like glue for chromatin by Gibbs, Eric B, Kriwacki, Richard W

“…Gibbs and Kriwacki comment on Turner et al's report that the CTD of chicken histone H1.11L (termed CH1) remains disordered and dynamic upon binding to short…”
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Investigating the molecular basis of ARF tumor suppressor function in the nucleolus: how ARF disrupts ribosome biogenesis and function by Gibbs, Eric B., Miao, Qi, Perrone, Barbara, Hassan, Alia, Kümmerle, Rainer, Kriwacki, Richard

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