Search Results - "Gibbs, Benjamin K"

Discovering Targets of Non-enzymatic Acylation by Thioester Reactivity Profiling by Kulkarni, Rhushikesh A, Worth, Andrew J, Zengeya, Thomas T, Shrimp, Jonathan H, Garlick, Julie M, Roberts, Allison M, Montgomery, David C, Sourbier, Carole, Gibbs, Benjamin K, Mesaros, Clementina, Tsai, Yien Che, Das, Sudipto, Chan, King C, Zhou, Ming, Andresson, Thorkell, Weissman, Allan M, Linehan, W Marston, Blair, Ian A, Snyder, Nathaniel W, Meier, Jordan L

“…Non-enzymatic protein modification driven by thioester reactivity is thought to play a major role in the establishment of cellular lysine acylation. However,…”
Get more information

High-throughput and targeted drug screens identify pharmacological candidates against MiT-translocation renal cell carcinoma by Lang, Martin, Schmidt, Laura S, Wilson, Kelli M, Ricketts, Christopher J, Sourbier, Carole, Vocke, Cathy D, Wei, Darmood, Crooks, Daniel R, Yang, Youfeng, Gibbs, Benjamin K, Zhang, Xiaohu, Klumpp-Thomas, Carleen, Chen, Lu, Guha, Rajarshi, Ferrer, Marc, McKnight, Crystal, Itkin, Zina, Wangsa, Darawalee, Wangsa, Danny, James, Amy, Difilippantonio, Simone, Karim, Baktir, Morís, Francisco, Ried, Thomas, Merino, Maria J, Srinivasan, Ramaprasad, Thomas, Craig J, Linehan, W Marston

“…MiT-Renal Cell Carcinoma (RCC) is characterized by genomic translocations involving microphthalmia-associated transcription factor (MiT) family members TFE3,…”
Get full text

Development and initial clinical testing of a multiplexed circulating tumor cell assay in patients with clear cell renal cell carcinoma by Bade, Rory M., Schehr, Jennifer L., Emamekhoo, Hamid, Gibbs, Benjamin K., Rodems, Tamara S., Mannino, Matthew C., Desotelle, Joshua A., Heninger, Erika, Stahlfeld, Charlotte N., Sperger, Jamie M., Singh, Anupama, Wolfe, Serena K., Niles, David J., Arafat, Waddah, Steinharter, John A., Jason Abel, E., Beebe, David J., Wei, Xiao X., McKay, Rana R., Choueri, Toni K., Lang, Joshua M.

“…Although therapeutic options for patients with advanced renal cell carcinoma (RCC) have increased in the past decade, no biomarkers are yet available for…”
Get full text

Detecting the Potential Pharmacological Synergy of Drug Combination by Viability Assays In Vitro by Gibbs, Benjamin K, Sourbier, Carole

“…Heat shock protein 90 (HSP90) is a molecular chaperone necessary for the folding and proper function of multiple "client" proteins. HSP90 is involved in…”
Get more information

CGE24-095: Microfluidic Characterization and Analysis of Circulating Tumor Cells from Patients with Metastatic Melanoma by Mannino, Matthew C, Zhao, George, Gibbs, Benjamin K, Schehr, Jennifer L, Lang, Joshua M, Ma, Vincent T

Get more information

Rapid In Vitro Cytotoxicity Evaluation of Jurkat Expressing Chimeric Antigen Receptor using Fluorescent Imaging by Subham, Siddharth, Jeppson, John D, Gibbs, Benjamin K, Babai, Jacqueline, Alker, Riza, Godwin, Andrew K, Akhavan, David

“…Chimeric antigen receptor (CAR) T cells are at the forefront of oncology. A CAR is constructed of a targeting domain (usually a single chain variable fragment,…”
Get more information

Integrated Analysis of Multiple Biomarkers from Circulating Tumor Cells Enabled by Exclusion-Based Analyte Isolation by Sperger, Jamie M, Strotman, Lindsay N, Welsh, Allison, Casavant, Benjamin P, Chalmers, Zachery, Horn, Sacha, Heninger, Erika, Thiede, Stephanie M, Tokar, Jacob, Gibbs, Benjamin K, Guckenberger, David J, Carmichael, Lakeesha, Dehm, Scott M, Stephens, Philip J, Beebe, David J, Berry, Scott M, Lang, Joshua M

“…There is a critical clinical need for new predictive and pharmacodynamic biomarkers that evaluate pathway activity in patients treated with targeted therapies…”
Get full text

Tracking Small Extracellular Vesicles Using a Minimally Invasive PicoGreen Labeling Strategy by Rayamajhi, Sagar, Gibbs, Benjamin K., Sipes, Jared, Pathak, Harsh B., Bossmann, Stefan H., Godwin, Andrew K.

“…Extracellular vesicles (EVs) are cell-secreted lipid bilayer delimited particles that mediate cellular communication. These tiny sacs of cellular information…”
Get full text

Inducing Mitotic Catastrophe as a Therapeutic Approach to Improve Outcomes in Ewing Sarcoma by Turaga, Soumya M, Vishwakarma, Vikalp, Hembruff, Stacey L, Gibbs, Benjamin K, Sabu, Priya, Puri, Rajni V, Pathak, Harsh B, Samuel, Glenson, Godwin, Andrew K

“…Ewing sarcoma (EWS) is an aggressive pediatric malignancy of the bone and soft tissues in need of novel therapeutic options. To identify potential therapeutic…”
Get full text

Targeting loss of the Hippo signaling pathway in NF2 -deficient papillary kidney cancers by Sourbier, Carole, Liao, Pei-Jyun, Ricketts, Christopher J, Wei, Darmood, Yang, Youfeng, Baranes, Sarah M, Gibbs, Benjamin K, Ohanjanian, Lernik, Spencer Krane, L, Scroggins, Bradley T, Keith Killian, J, Wei, Ming-Hui, Kijima, Toshiki, Meltzer, Paul S, Citrin, Deborah E, Neckers, Len, Vocke, Cathy D, Marston Linehan, W

“…Papillary renal cell carcinomas (PRCC) are a histologically and genetically heterogeneous group of tumors that represent 15-20% of all kidney neoplasms and may…”
Get full text

Abstract 4585: Development of multi-marker capture and analysis of circulating tumor cells in renal cell carcinoma by Bade, Rory M., Gibbs, Benjamin K., Sperger, Jamie M., Kyriakopolous, Christos, Emamekhoo, Hamid, McKay, Rana R., Choueiri, Toni K., Lang, Joshua M.

“…Abstract Purpose: Circulating biomarkers are an emerging tool to monitor treatment response and the emergence of resistant phenotypes. However, studies of…”
Get full text

Abstract 3159: Identification of circulating tumor cells from renal cell carcinoma patients by a multi-parameter flow cytometry assay by Desotelle, Joshua A., Pak, Chorom, Heninger, Erika, Schehr, Jennifer L., McKay, Rana R., Gibbs, Benjamin K., Norton, Craig, Choueiri, Toni K., Lang, Joshua M.

“…Abstract BACKGROUND: Renal cell carcinoma (RCC) is one of the top ten causes of cancer death in the United States. The last ten years have shown a dramatic…”
Get full text

Abstract 5334: Targeting the KIF15-TPX2 PPI to overcome KIF11 inhibitor resistance in epithelial ovarian cancer by Gibbs, Benjamin K., Douglas, Justin T., Wates, Rebecca J., McDonald, Peter R., Whitaker, Amy M., Ndi, Cornelius N., Pathak, Harsh B., Harned, Laurie A., Neuenswander, Sarah A., Broward, Melinda A., Freudenthal, Bret D., Roy, Anuradha, Schoenen, Frank J., Godwin, Andrew K.

“…Abstract Most cases of epithelial ovarian cancer (EOC) exhibit extensive molecular heterogeneity, presenting challenges in developing targeted therapies…”
Get full text

Abstract 4816: Development of an integrated analysis platform of circulating melanoma cells for PD-L1 expression as a predictive biomarker by Gibbs, Benjamin K., Strotman, Lindsay N., Thiede, Stephanie M., Sperger, Jamie M., Casavant, Benjamin P., Berry, Scott M., Beebe, David J., Lang, Joshua M.

“…Abstract Novel therapies that target the PD-1/PD-L1 axis have shown great potential to improve survival for patients with advanced melanoma. However, there are…”
Get full text