Search Results - "Gibbs, B. R."

GPR30 is positioned to mediate estrogen effects on basal forebrain cholinergic neurons and cognitive performance by Hammond, R, Gibbs, R.B

“…Abstract Beneficial effects of estrogen therapy on cognitive performance diminish with age and time following the loss of ovarian function. This has led to the…”
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Chronic treatment with a GPR30 antagonist impairs acquisition of a spatial learning task in young female rats by Hammond, R., Nelson, D., Kline, E., Gibbs, R.B.

“…We hypothesize that the beneficial effects of estradiol on cognitive performance may be mediated through GPR30, a putative membrane target of estrogens…”
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Role of GPR30 in mediating estradiol effects on acetylcholine release in the hippocampus by Gibbs, R.B., Nelson, D., Hammond, R.

“…We have hypothesized that estradiol enhances basal forebrain cholinergic function and cognitive performance, at least in part, via activation of the novel…”
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GPR30 co-localizes with cholinergic neurons in the basal forebrain and enhances potassium-stimulated acetylcholine release in the hippocampus by Hammond, R, Nelson, D, Gibbs, R.B

“…Summary GPR30 is a novel, membrane-bound, G-protein coupled estrogen receptor ( Filardo et al., 2002; Prossnitz et al., 2008 ). We hypothesize that GPR30 may…”
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Chronic treatment with estrogen receptor agonists restores acquisition of a spatial learning task in young ovariectomized rats by Hammond, R., Mauk, R., Ninaci, D., Nelson, D., Gibbs, R.B.

“…Previous work has shown that continuous estradiol replacement in young ovariectomized rats enhances acquisition of a delayed matching-to-position (DMP) T-maze…”
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Impact of estrogen receptor agonists and model of menopause on enzymes involved in brain metabolism, acetyl-CoA production and cholinergic function by Kirshner, Z.Z., Yao, Jeffrey K., Li, Junyi, Long, Tao, Nelson, Doug, Gibbs, R.B.

“…Our goal is to understand how loss of circulating estrogens and estrogen replacement affect brain physiology and function, particularly in brain regions…”
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Effects of gonadal hormone replacement on measures of basal forebrain cholinergic function by Gibbs, R.B

“…The effects of different hormone replacement regimens on basal forebrain cholinergic function were examined by measuring changes in choline acetyltransferase…”
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Long-term treatment with estrogen and progesterone enhances acquisition of a spatial memory task by ovariectomized aged rats by Gibbs, Robert B

“…Female Sprague–Dawley rats were ovariectomized at 13 months of age. Four groups received different regimens of estrogen or estrogen plus progesterone…”
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Studies of the Localisation of Kisspeptin Within the Pituitary of the Rhesus Monkey (Macaca mulatta) and the Effect of Kisspeptin on the Release of Non-Gonadotropic Pituitary Hormones by Ramaswamy, S., Gibbs, R. B., Plant, T. M.

“…Kisspeptin neurones in the arcuate nucleus play a pivotal role in the regulation of hypothalamic gonadotrophin‐releasing hormone (GnRH) secretion in higher…”
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Galanthamine plus estradiol treatment enhances cognitive performance in aged ovariectomized rats by Gibbs, R.B., Chipman, A.M., Hammond, R., Nelson, D.

“…We hypothesize that beneficial effects of estradiol on cognitive performance diminish with age and time following menopause due to a progressive decline in…”
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Donepezil treatment restores the ability of estradiol to enhance cognitive performance in aged rats: Evidence for the cholinergic basis of the critical period hypothesis by Gibbs, R.B., Mauk, R., Nelson, D., Johnson, D.A.

“…Recent studies suggest that the ability of estradiol to enhance cognitive performance diminishes with age and/or time following loss of ovarian function. We…”
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Donepezil plus estradiol treatment enhances learning and delay-dependent memory performance by young ovariectomized rats with partial loss of septal cholinergic neurons by Gibbs, R.B., Chipman, A.M., Nelson, D.

“…Effects of estrogen therapy on cognitive performance appear to diminish with age and time following the loss of ovarian function. We hypothesize that this is…”
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Treatment with estrogen and progesterone affects relative levels of brain-derived neurotrophic factor mRNA and protein in different regions of the adult rat brain by Gibbs, Robert B

“…Quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) and enzyme-linked immunosorbent assay (ELISA) were used to examine the effects of acute…”
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Estrogen Replacement Enhances Acquisition of a Spatial Memory Task and Reduces Deficits Associated with Hippocampal Muscarinic Receptor Inhibition by Gibbs, Robert B.

“…A delayed matching-to-position (DMP) T-maze task was used to examine the effects of estrogen replacement on spatial learning and memory, as well as the ability…”
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Effects of Ageing and Long-Term Hormone Replacement on Cholinergic Neurones in the Medial Septum and Nucleus Basalis Magnocellularis of Ovariectomized Rats by Gibbs, R. B.

“…Ovariectomized aged rats, some of which received long‐term hormone replacement with oestrogen or oestrogen plus progesterone, were evaluated for the number and…”
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Use of the REVERT® total protein stain as a loading control demonstrates significant benefits over the use of housekeeping proteins when analyzing brain homogenates by Western blot: An analysis of samples representing different gonadal hormone states by Kirshner, Z.Z., Gibbs, R.B.

“…Western blot is routinely used to quantify differences in the levels of target proteins in tissues. Standard methods typically use measurements of housekeeping…”
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Levels of trkA and BDNF mRNA, but not NGF mRNA, fluctuate across the estrous cycle and increase in response to acute hormone replacement by Gibbs, Robert B.

“…Recent studies suggest that hormone replacement therapy can help to reduce the risk and severity of Alzheimer's-related dementia in postmenopausal women. We…”
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Cholinergic lesions produce task-selective effects on delayed matching to position and configural association learning related to response pattern and strategy by Gibbs, R.B., Johnson, D.A.

“…192IgG-saporin (SAP) was used to selectively destroy cholinergic neurons in the rostral basal forebrain (e.g., medial septum (MS) and vertical limb of the…”
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The effect of the steroid sulfatase inhibitor (p-O-sulfamoyl)-tetradecanoyl tyramine (DU-14) on learning and memory in rats with selective lesion of septal–hippocampal cholinergic tract by Babalola, P.A., Fitz, N.F., Gibbs, R.B., Flaherty, P.T., Li, P.-K., Johnson, D.A.

“…► Steroid sulfatase inhibition and cholinergic lesion of the hippocampus was tested. ► SSI enhanced retention memory in lesioned rats in the passive avoidance…”
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Impairment of Basal Forebrain Cholinergic Neurons Associated with Aging and Long-Term Loss of Ovarian Function by Gibbs, Robert B.

“…Recent studies suggest that women are at greater risk for Alzheimer's disease than men and that estrogen replacement can help to reduce the risk and severity…”
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