Search Results - "Gibbons, William J"
-
1
Biosynthesis of psilocybin and its nonnatural derivatives by a promiscuous psilocybin synthesis pathway in Escherichia coli
Published in Biotechnology and bioengineering (01-08-2023)“…Traditional psychedelics are undergoing a transformation from recreational drugs, to promising pharmaceutical drug candidates with the potential to provide an…”
Get full text
Journal Article -
2
Effect of psilocybin on decision-making and motivation in the healthy rat
Published in Behavioural brain research (25-02-2023)“…Psilocybin and its active metabolite psilocin are hallucinogenic serotonergic agonists with high affinity for several serotonin receptors. In addition to…”
Get full text
Journal Article -
3
Gpr63 is a modifier of microcephaly in Ttc21b mouse mutants
Published in PLoS genetics (15-11-2019)“…The primary cilium is a signaling center critical for proper embryonic development. Previous studies have demonstrated that mice lacking Ttc21b have impaired…”
Get full text
Journal Article -
4
Heart disease in a mutant mouse model of spontaneous eosinophilic myocarditis maps to three loci
Published in BMC genomics (11-10-2019)“…Heart disease (HD) is the major cause of morbidity and mortality in patients with hypereosinophilic diseases. Due to a lack of adequate animal models, our…”
Get full text
Journal Article -
5
Pharmacological and behavioural effects of tryptamines present in psilocybin‐containing mushrooms
Published in British journal of pharmacology (01-10-2024)“…Background and Purpose Demand for new antidepressants has resulted in a re‐evaluation of the therapeutic potential of psychedelic drugs. Several tryptamines…”
Get full text
Journal Article -
6
Evaluation of TrpM and PsiD substrate promiscuity reveals new biocatalytic capabilities
Published in Biotechnology progress (18-06-2024)“…N-methylated tryptamines, such as the hallucinogenic natural products, psilocybin and N,N-dimethyltryptamine (DMT), are gaining interest from the medical…”
Get full text
Journal Article -
7
Characterization of a mouse model of hypereosinophilia-associated heart disease
Published in American journal of physiology. Heart and circulatory physiology (01-08-2019)“…Hypereosinophilic syndrome is characterized by sustained and marked eosinophilia leading to tissue damage and organ dysfunction. Morbidity and mortality occur…”
Get more information
Journal Article -
8
Development of an E. coli-based norbaeocystin production platform and evaluation of behavioral effects in rats
Published in Metabolic engineering communications (01-06-2022)“…Interest in the potential therapeutic efficacy of psilocybin and other psychedelic compounds has escalated significantly in recent years. To date, little is…”
Get full text
Journal Article -
9
In vivo biosynthesis of N,N-dimethyltryptamine, 5-MeO-N,N-dimethyltryptamine, and bufotenine in E.coli
Published in Metabolic engineering (01-07-2023)“…N,N-dimethyltryptamine (DMT), 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) and 5-hydroxy-N,N-dimethyltryptamine (bufotenine) are psychedelic tryptamines found…”
Get full text
Journal Article -
10
Age and Sex of Mice Markedly Affect Survival Times Associated with Hyperoxic Acute Lung Injury
Published in PloS one (23-06-2015)“…Mortality associated with acute lung injury (ALI) remains substantial, with recent estimates of 35-45% similar to those obtained decades ago. Although evidence…”
Get full text
Journal Article -
11
Homebrewed psilocybin: can new routes for pharmaceutical psilocybin production enable recreational use?
Published in Bioengineered (01-01-2021)“…Psilocybin, a drug most commonly recognized as a recreational psychedelic, is quickly gaining attention as a promising therapy for an expanding range of…”
Get full text
Journal Article -
12
Genomewide Association Analysis of Respiratory Syncytial Virus Infection in Mice
Published in Journal of Virology (01-03-2010)“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text
Journal Article -
13
Synchronizing allelic effects of opposing quantitative trait loci confirmed a major epistatic interaction affecting acute lung injury survival in mice
Published in PloS one (29-05-2012)“…Increased oxygen (O(2)) levels help manage severely injured patients, but too much for too long can cause acute lung injury (ALI), acute respiratory distress…”
Get full text
Journal Article -
14
Iatrogenic “buffalo chest” bilateral pneumothoraces following unilateral transbronchial lung biopsies in a bilateral lung transplant recipient
Published in Respiratory medicine case reports (01-01-2015)“…Abstract We present a 54 year old male patient who had a bilateral lung transplant sixteen years ago for Alpha-1 Antitrypsin Deficiency-related emphysema. He…”
Get full text
Journal Article -
15
A genetic mouse model to investigate hyperoxic acute lung injury survival
Published in Physiological genomics (20-08-2007)“…1 Department of Pediatrics, University of Cincinnati College of Medicine, Children's Hospital Medical Center, Cincinnati, Ohio 2 Division and Program in Human…”
Get full text
Journal Article -
16
Reciprocal backcross mice confirm major loci linked to hyperoxic acute lung injury survival time
Published in Physiological genomics (01-07-2009)“…1 Department of Pediatrics, University of Cincinnati College of Medicine, Children's Hospital Medical Center, Cincinnati, Ohio 2 Division and Program in Human…”
Get full text
Journal Article -
17
Genetic analysis of hyperoxic acute lung injury survival in reciprocal intercross mice
Published in Physiological genomics (20-08-2007)“…1 Department of Pediatrics, University of Cincinnati College of Medicine, Children's Hospital Medical Center, Cincinnati, Ohio 2 Division and Program in Human…”
Get full text
Journal Article -
18
-
19
Reciprocal Congenic Lines of Mice Capture the Aliq1 Effect on Acute Lung Injury Survival Time
Published in American journal of respiratory cell and molecular biology (01-01-2008)“…Acute lung injury (ALI) is a devastating condition resulting from diverse causes. Genetic studies of human populations indicate that ALI is a complex disease…”
Get full text
Journal Article -
20
ATS statement on six-minute walk test
Published in American journal of respiratory and critical care medicine (01-05-2003)Get full text
Journal Article