Search Results - "Gibbons, William J"

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    Biosynthesis of psilocybin and its nonnatural derivatives by a promiscuous psilocybin synthesis pathway in Escherichia coli by Flower, Jessica E., Gibbons, William J., Adams, Alexandra M., Wang, Xin, Broude, Caroline N., Jones, J. Andrew

    Published in Biotechnology and bioengineering (01-08-2023)
    “…Traditional psychedelics are undergoing a transformation from recreational drugs, to promising pharmaceutical drug candidates with the potential to provide an…”
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    Effect of psilocybin on decision-making and motivation in the healthy rat by Roberts, Brianna F., Zylko, Alexia L., Waters, Courtney E., Crowder, Jessica D., Gibbons, William J., Sen, Abhishek K., Jones, J. Andrew, McMurray, Matthew S.

    Published in Behavioural brain research (25-02-2023)
    “…Psilocybin and its active metabolite psilocin are hallucinogenic serotonergic agonists with high affinity for several serotonin receptors. In addition to…”
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    Gpr63 is a modifier of microcephaly in Ttc21b mouse mutants by Snedeker, John, Gibbons, Jr, William J, Paulding, David F, Abdelhamed, Zakia, Prows, Daniel R, Stottmann, Rolf W

    Published in PLoS genetics (15-11-2019)
    “…The primary cilium is a signaling center critical for proper embryonic development. Previous studies have demonstrated that mice lacking Ttc21b have impaired…”
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    Heart disease in a mutant mouse model of spontaneous eosinophilic myocarditis maps to three loci by Zimmermann, Nives, Gibbons, Jr, William J, Homan, Shelli M, Prows, Daniel R

    Published in BMC genomics (11-10-2019)
    “…Heart disease (HD) is the major cause of morbidity and mortality in patients with hypereosinophilic diseases. Due to a lack of adequate animal models, our…”
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    Pharmacological and behavioural effects of tryptamines present in psilocybin‐containing mushrooms by Rakoczy, Ryan J., Runge, Grace N., Sen, Abhishek K., Sandoval, Oscar, Wells, Hunter G., Nguyen, Quynh, Roberts, Brianna R., Sciortino, Jon H., Gibbons, William J., Friedberg, Lucas M., Jones, J. Andrew, McMurray, Matthew S.

    Published in British journal of pharmacology (01-10-2024)
    “…Background and Purpose Demand for new antidepressants has resulted in a re‐evaluation of the therapeutic potential of psychedelic drugs. Several tryptamines…”
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    Evaluation of TrpM and PsiD substrate promiscuity reveals new biocatalytic capabilities by Kanis, Fiona C, Broude, Caroline N, Hellwarth, Elle B, Gibbons, Jr, William J, Sen, Abhishek K, Adams, Alexandra M, Wang, Xin, Jones, J Andrew

    Published in Biotechnology progress (18-06-2024)
    “…N-methylated tryptamines, such as the hallucinogenic natural products, psilocybin and N,N-dimethyltryptamine (DMT), are gaining interest from the medical…”
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    Characterization of a mouse model of hypereosinophilia-associated heart disease by Prows, Daniel R, Klingler, Andrea, Gibbons, Jr, William J, Homan, Shelli M, Zimmermann, Nives

    “…Hypereosinophilic syndrome is characterized by sustained and marked eosinophilia leading to tissue damage and organ dysfunction. Morbidity and mortality occur…”
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    Development of an E. coli-based norbaeocystin production platform and evaluation of behavioral effects in rats by Adams, Alexandra M., Anas, Nicholas A., Sen, Abhishek K., Hinegardner-Hendricks, Jordan D., O’Dell, Philip J., Gibbons, William J., Flower, Jessica E., McMurray, Matthew S., Jones, J. Andrew

    Published in Metabolic engineering communications (01-06-2022)
    “…Interest in the potential therapeutic efficacy of psilocybin and other psychedelic compounds has escalated significantly in recent years. To date, little is…”
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    In vivo biosynthesis of N,N-dimethyltryptamine, 5-MeO-N,N-dimethyltryptamine, and bufotenine in E.coli by Friedberg, Lucas M., Sen, Abhishek K., Nguyen, Quynh, Tonucci, Gabriel P., Hellwarth, Elle B., Gibbons, William J., Jones, J. Andrew

    Published in Metabolic engineering (01-07-2023)
    “…N,N-dimethyltryptamine (DMT), 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) and 5-hydroxy-N,N-dimethyltryptamine (bufotenine) are psychedelic tryptamines found…”
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    Age and Sex of Mice Markedly Affect Survival Times Associated with Hyperoxic Acute Lung Injury by Prows, Daniel R, Gibbons, Jr, William J, Smith, Jessica J, Pilipenko, Valentina, Martin, Lisa J

    Published in PloS one (23-06-2015)
    “…Mortality associated with acute lung injury (ALI) remains substantial, with recent estimates of 35-45% similar to those obtained decades ago. Although evidence…”
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    Homebrewed psilocybin: can new routes for pharmaceutical psilocybin production enable recreational use? by Gibbons, William J., McKinney, Madeline G., O'Dell, Philip J., Bollinger, Brooke A., Jones, J. Andrew

    Published in Bioengineered (01-01-2021)
    “…Psilocybin, a drug most commonly recognized as a recreational psychedelic, is quickly gaining attention as a promising therapy for an expanding range of…”
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    Genomewide Association Analysis of Respiratory Syncytial Virus Infection in Mice by STARK, James M, BARMADA, M. Michael, MAILAPARAMBIL, Beena, KRUEGER, Marcus, HEINZMANN, Andrea, LEIKAUF, George D, PROWS, Daniel R, WINTERBERG, Abby V, MAJUMBER, Nilanjana, GIBBONS, William J, STARK, Marilyn A, SARTOR, Maureen A, MEDVEDOVIC, Mario, KOLLS, Jay, BEIN, Kiflai

    Published in Journal of Virology (01-03-2010)
    “…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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    Synchronizing allelic effects of opposing quantitative trait loci confirmed a major epistatic interaction affecting acute lung injury survival in mice by Prows, Daniel R, Gibbons, Jr, William J, Burzynski, Benjamin B

    Published in PloS one (29-05-2012)
    “…Increased oxygen (O(2)) levels help manage severely injured patients, but too much for too long can cause acute lung injury (ALI), acute respiratory distress…”
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    Iatrogenic “buffalo chest” bilateral pneumothoraces following unilateral transbronchial lung biopsies in a bilateral lung transplant recipient by Sawalha, Leith, Gibbons, William J

    Published in Respiratory medicine case reports (01-01-2015)
    “…Abstract We present a 54 year old male patient who had a bilateral lung transplant sixteen years ago for Alpha-1 Antitrypsin Deficiency-related emphysema. He…”
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    A genetic mouse model to investigate hyperoxic acute lung injury survival by Prows, Daniel R, Hafertepen, Amanda P, Gibbons, William J., Jr, Winterberg, Abby V, Nick, Todd G

    Published in Physiological genomics (20-08-2007)
    “…1 Department of Pediatrics, University of Cincinnati College of Medicine, Children's Hospital Medical Center, Cincinnati, Ohio 2 Division and Program in Human…”
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    Reciprocal backcross mice confirm major loci linked to hyperoxic acute lung injury survival time by Prows, Daniel R, Winterberg, Abby V, Gibbons, William J., Jr, Burzynski, Benjamin B, Liu, Chunyan, Nick, Todd G

    Published in Physiological genomics (01-07-2009)
    “…1 Department of Pediatrics, University of Cincinnati College of Medicine, Children's Hospital Medical Center, Cincinnati, Ohio 2 Division and Program in Human…”
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    Genetic analysis of hyperoxic acute lung injury survival in reciprocal intercross mice by Prows, Daniel R, Hafertepen, Amanda P, Winterberg, Abby V, Gibbons, William J., Jr, Liu, Chunyan, Nick, Todd G

    Published in Physiological genomics (20-08-2007)
    “…1 Department of Pediatrics, University of Cincinnati College of Medicine, Children's Hospital Medical Center, Cincinnati, Ohio 2 Division and Program in Human…”
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    Reciprocal Congenic Lines of Mice Capture the Aliq1 Effect on Acute Lung Injury Survival Time by Prows, Daniel R, Hafertepen, Amanda P, Winterberg, Abby V, Gibbons, William J., Jr, Wesselkamper, Scott C, Singer, Jonathan B, Hill, Annie E, Nadeau, Joseph H, Leikauf, George D

    “…Acute lung injury (ALI) is a devastating condition resulting from diverse causes. Genetic studies of human populations indicate that ALI is a complex disease…”
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