Search Results - "Gibbins, M."

Aberrant glycosylation of anti-SARS-CoV-2 spike IgG is a prothrombotic stimulus for platelets by Bye, Alexander P., Hoepel, Willianne, Mitchell, Joanne L., Jégouic, Sophie, Loureiro, Silvia, Sage, Tanya, Vidarsson, Gestur, Nouta, Jan, Wuhrer, Manfred, de Taeye, Steven, van Gils, Marit, Kriek, Neline, Cooper, Nichola, Jones, Ian, den Dunnen, Jeroen, Gibbins, Jonathan M.

“…A subset of patients with coronavirus disease 2019 (COVID-19) become critically ill, suffering from severe respiratory problems and also increased rates of…”
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Lipopolysaccharide potentiates platelet responses via toll-like receptor 4-stimulated Akt-Erk-PLA2 signalling by Lopes Pires, Maria E, Clarke, Simon R, Marcondes, Sisi, Gibbins, Jonathan M

“…Lipopolysaccharide (LPS) from the cell envelope of Gram-negative bacteria is a principal cause of the symptoms of sepsis. LPS has been reported to modulate the…”
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Snakebite and its socio-economic impact on the rural population of Tamil Nadu, India by Vaiyapuri, Sakthivel, Vaiyapuri, Rajendran, Ashokan, Rajesh, Ramasamy, Karthikeyan, Nattamaisundar, Kameshwaran, Jeyaraj, Anburaj, Chandran, Viswanathan, Gajjeraman, Prabu, Baksh, M Fazil, Gibbins, Jonathan M, Hutchinson, E Gail

“…Snakebite represents a significant health issue worldwide, affecting several million people each year with as many as 95,000 deaths. India is considered to be…”
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Functional redundancy between RAP1 isoforms in murine platelet production and function by Stefanini, Lucia, Lee, Robert H., Paul, David S., O'Shaughnessy, Ellen C., Ghalloussi, Dorsaf, Jones, Christopher I., Boulaftali, Yacine, Poe, Kathryn O., Piatt, Raymond, Kechele, Dan O., Caron, Kathleen M., Hahn, Klaus M., Gibbins, Jonathan M., Bergmeier, Wolfgang

“…RAP GTPases, important regulators of cellular adhesion, are abundant signaling molecules in the platelet/megakaryocytic lineage. However, mice lacking the…”
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Mind the gap: connexins and pannexins in platelet function by Taylor, Kirk a, Little, Gemma, Gibbins, Jonathan M.

“…Connexins are a family of gap junction forming proteins widely expressed by mammalian cells. They assemble into hexameric hemichannels, which can either…”
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Connexins and Pannexins in Vascular Function and Disease by Molica, Filippo, Figueroa, Xavier F, Kwak, Brenda R, Isakson, Brant E, Gibbins, Jonathan M

“…Connexins (Cxs) and pannexins (Panxs) are ubiquitous membrane channel forming proteins that are critically involved in many aspects of vascular physiology and…”
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Mode of induction of platelet-derived extracellular vesicles is a critical determinant of their phenotype and function by Ferreira, P. M., Bozbas, E., Tannetta, S. D., Alroqaiba, N., Zhou, R., Crawley, J. T. B., Gibbins, J. M., Jones, C. I., Ahnström, J., Yaqoob, P.

“…Platelet-derived extracellular vesicles (PDEVs) are the most abundant amongst all types of EVs in the circulation. However, the mechanisms leading to PDEVs…”
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Modeling thrombosis in silico: Frontiers, challenges, unresolved problems and milestones by Belyaev, A.V., Dunster, J.L., Gibbins, J.M., Panteleev, M.A., Volpert, V.

“…Hemostasis is a complex physiological mechanism that functions to maintain vascular integrity under any conditions. Its primary components are blood platelets…”
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An agent-based approach for modelling and simulation of glycoprotein VI receptor diffusion, localisation and dimerisation in platelet lipid rafts by Tantiwong, Chukiat, Dunster, Joanne L., Cavill, Rachel, Tomlinson, Michael G., Wierling, Christoph, Heemskerk, Johan W. M., Gibbins, Jonathan M.

“…Receptor diffusion plays an essential role in cellular signalling via the plasma membrane microenvironment and receptor interactions, but the regulation is not…”
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Platelet adhesion signalling and the regulation of thrombus formation by Gibbins, Jonathan M

“…Platelets perform a central role in haemostasis and thrombosis. They adhere to subendothelial collagens exposed at sites of blood vessel injury via the…”
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Pirtobrutinib results in reversible platelet dysfunction compared to ibrutinib and acalabrutinib by Bye, Alexander P, Kriek, Neline, Sage, Tanya, Rawlings, Suzannah J, Prodger, Catherine, Kesavan, Murali, Lees, Charlotte, Booth, Stephen, Cowen, Louise G, Shefferd, Kirsty, Desborough, Michael J, Gibbins, Jonathan M, Eyre, Toby A

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Targeting platelet inhibition receptors for novel therapies: PECAM-1 and G6b-B by Soriano Jerez, Eva M, Gibbins, Jonathan M, Hughes, Craig E

“…While current oral antiplatelet therapies benefit many patients, they deregulate the hemostatic balance leaving patients at risk of systemic side-effects such…”
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Zinc regulates reactive oxygen species generation in platelets by Lopes-Pires, M.E., Ahmed, N. S., Vara, D., Gibbins, J. M., Pula, G., Pugh, N.

“…Vascular complications resulting from atherosclerosis development are a major cause of death. Reactive oxygen species (ROS) are produced by platelets during…”
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Regulation of Glycoprotein VI-Dependent Platelet Activation and Thrombus Formation by Heparan Sulfate Proteoglycan Perlecan by Provenzale, Isabella, De Simone, Ilaria, Gibbins, Jonathan M, Heemskerk, Johan W. M, van der Meijden, Paola E. J, Jones, Chris I

“…Proteoglycans form a heterogeneous family of proteins with covalently bound sulfated glycosaminoglycans. The extracellular matrix proteoglycan perlecan has…”
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Delineating Zinc Influx Mechanisms during Platelet Activation by Kuravi, Sahithi J, Ahmed, Niaz S, Taylor, Kirk A, Capes, Emily M, Bye, Alex, Unsworth, Amanda J, Gibbins, Jonathan M, Pugh, Nicholas

“…Zinc (Zn ) is released by platelets during a hemostatic response to injury. Extracellular zinc ([Zn ] ) initiates platelet activation following influx into the…”
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Syncytiotrophoblast Extracellular Vesicles from Pre-Eclampsia Placentas Differentially Affect Platelet Function by Tannetta, Dionne S, Hunt, Kathryn, Jones, Chris I, Davidson, Naomi, Coxon, Carmen H, Ferguson, David, Redman, Christopher W, Gibbins, Jonathan M, Sargent, Ian L, Tucker, Katherine L

“…Pre-eclampsia (PE) complicates around 3% of all pregnancies and is one of the most common causes of maternal mortality worldwide. The pathophysiology of PE…”
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RXR Ligands Negatively Regulate Thrombosis and Hemostasis by Unsworth, Amanda J, Flora, Gagan D, Sasikumar, Parvathy, Bye, Alexander P, Sage, Tanya, Kriek, Neline, Crescente, Marilena, Gibbins, Jonathan M

“…OBJECTIVE—Platelets have been found to express intracellular nuclear receptors including the retinoid X receptors (RXRα and RXRβ). Treatment of platelets with…”
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Gap junctions and connexin hemichannels in the regulation of haemostasis and thrombosis by Vaiyapuri, Sakthivel, Flora, Gagan D, Gibbins, Jonathan M

“…Platelets are involved in the maintenance of haemostasis but their inappropriate activation leads to thrombosis, a principal trigger for heart attack and…”
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Myricetin, the Main Flavonoid in Syzygium cumini Leaf, Is a Novel Inhibitor of Platelet Thiol Isomerases PDI and ERp5 by Gaspar, Renato Simões, da Silva, Samira Abdalla, Stapleton, Jennifer, Fontelles, João Lucas de Lima, Sousa, Hiran Reis, Chagas, Vinicyus Teles, Alsufyani, Shuruq, Trostchansky, Andrés, Gibbins, Jonathan M, Paes, Antonio Marcus de Andrade

“…Flavonoids have been characterized as a prominent class of compounds to treat thrombotic diseases through the inhibition of thiol isomerases. is a…”
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Antiplatelet properties of Pim kinase inhibition are mediated through disruption of thromboxane A2 receptor signaling by Unsworth, Amanda J, Bye, Alexander P, Sage, Tanya, Gaspar, Renato S, Eaton, Nathan, Drew, Caleb, Stainer, Alexander, Kriek, Neline, Volberding, Peter J, Hutchinson, James L, Riley, Ryan, Jones, Sarah, Mundell, Stuart J, Cui, Weiguo, Falet, Hervé, Gibbins, Jonathan M

“…Pim kinases are upregulated in several forms of cancer, contributing to cell survival and tumour development, but their role in platelet function and…”
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