Search Results - "Giatromanolaki, A"

Tumor microenvironment, immune response and post-radiotherapy tumor clearance by Koukourakis, M. I., Giatromanolaki, A.

“…Radiotherapy is the treatment of choice for many cancer patients. Residual tumor leads to local recurrence after a period of an equilibrium created between…”
Get full text

Cancer stem cell phenotype relates to radio-chemotherapy outcome in locally advanced squamous cell head–neck cancer by Koukourakis, M I, Giatromanolaki, A, Tsakmaki, V, Danielidis, V, Sivridis, E

“…Background: Cancer stem cells (CSCs) tend to repopulate malignant tumours during radiotherapy and, therefore, prolongation of the overall treatment time may…”
Get full text

Successful response in a case of severe pustular psoriasis after interleukin‐1β inhibition by Skendros, P., Papagoras, C., Lefaki, I., Giatromanolaki, A., Kotsianidis, I., Speletas, M., Bocly, V., Theodorou, I., Dalla, V., Ritis, K.

“…Summary Generalized pustular psoriasis (GPP) is a severe type of psoriasis accompanied by systemic and often life‐threatening manifestations. The efficacy of…”
Get full text

Beclin 1 over- and underexpression in colorectal cancer: distinct patterns relate to prognosis and tumour hypoxia by Koukourakis, M I, Giatromanolaki, A, Sivridis, E, Pitiakoudis, M, Gatter, K C, Harris, A L

“…Introduction: Autophagy enables cells to recycle long-lived proteins or damaged organelles. Beclin 1, the mammalian orthologue of the yeast Apg6 /Vps30 gene,…”
Get full text

Targeting the epigenome in malignant melanoma: Facts, challenges and therapeutic promises by Anestopoulos, I., Kyriakou, S., Tragkola, V., Paraskevaidis, I., Tzika, E., Mitsiogianni, M., Deligiorgi, M.V., Petrakis, G., Trafalis, D.T., Botaitis, S., Giatromanolaki, A., Koukourakis, M.I., Franco, R., Pappa, A., Panayiotidis, M.I.

“…Malignant melanoma is the most lethal type of skin cancer with high rates of mortality. Although current treatment options provide a short-clinical benefit,…”
Get full text

PDK-1 regulates lactate production in hypoxia and is associated with poor prognosis in head and neck squamous cancer by Wigfield, S M, Winter, S C, Giatromanolaki, A, Taylor, J, Koukourakis, M L, Harris, A L

“…Here we describe the expression and function of a HIF-1-regulated protein pyruvate dehydrogenase kinase-1 (PDK-1) in head and neck squamous cancer (HNSCC)…”
Get full text

Lactate dehydrogenase 5 isoenzyme overexpression defines resistance of prostate cancer to radiotherapy by Koukourakis, M I, Giatromanolaki, A, Panteliadou, M, Pouliliou, S E, Chondrou, P S, Mavropoulou, S, Sivridis, E

“…Background: Radiotherapy provides high-cure rates in prostate cancer. Despite its overall slow clinical growth, high proliferation rates documented in a subset…”
Get full text

Lactate dehydrogenase-5 (LDH-5) overexpression in non-small-cell lung cancer tissues is linked to tumour hypoxia, angiogenic factor production and poor prognosis by Koukourakis, M I, Giatromanolaki, A, Sivridis, E, Bougioukas, G, Didilis, V, Gatter, K C, Harris, A L

“…Lactate dehydrogenase-5 (LDH-5) catalyses the reversible transformation of pyruvate to lactate, having a principal position in the anaerobic cellular…”
Get full text

Autophago-Lysosomal Flux Following Exposure of Endothelial Cells and Fibroblasts to Ionizing Radiation by Koukourakis, M.I, Kalamida, D, Karagounis, I, Giatromanolaki, A

Get full text

Relation of hypoxia inducible factor 1α and 2α in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival by GIATROMANOLAKI, A, KOUKOURAKIS, M. I, SIVRIDIS, E, TURLEY, H, TALKS, K, PEZZELLA, F, GATTER, K. C, HARRIS, A. L

“…Hypoxia inducible factors HIF1alpha and HIF2alpha are important proteins involved in the regulation of the transcription of a variety of genes related to…”
Get full text

Vascular endothelial growth factor, platelet-derived endothelial cell growth factor and angiogenesis in non-small-cell lung cancer by O'BYRNE, K. J, KOUKOURAKIS, M. I, GIATROMANOLAKI, A, COX, G, TURLEY, H, STEWARD, W. P, GATTER, K, HARRIS, A. L

“…High microvessel density, an indirect measure of angiogenesis, has been shown to correlate with increased tumour size, lymph node involvement and poor…”
Get full text

Prospective neoadjuvant analysis of PET imaging and mechanisms of resistance to Trastuzumab shows role of HIF1 and autophagy by Koukourakis, M I, Giatromanolaki, A, Bottini, A, Cappelletti, M R, Zanotti, L, Allevi, G, Strina, C, Ardine, M, Milani, M, Brugnoli, G, Martinotti, M, Ferrero, G, Bertoni, R, Ferrozzi, F, Harris, A L, Generali, D

“…Background: Although Trastuzumab has improved survival of HER2+ breast cancer patients, resistance to the agent pre-exists or develops through the course of…”
Get full text

Autophagy and hypoxia in colonic adenomas related to aggressive features by Giatromanolaki, A., Koukourakis, M. I., Koutsopoulos, A. V., Harris, A. L., Gatter, K. C., Sivridis, E.

“…Aim The study investigated whether autophagic activity and hypoxia parallel the adenoma–carcinoma sequence. Method The study comprised 120 tubular adenomas…”
Get full text

Activated Vegfr2/kdr Pathway In Tumour Cells And Tumour Associated Vessels Of Colorectal Cancer by Giatromanolaki, A., Koukourakis, M. I., Sivridis, E., Chlouverakis, G., Vourvouhaki, E., Turley, H., Harris, A. L., Gatter, K. C.

“…Background  Vascular endothelial cell growth factor (VEGF) acts by phosphorylating specific tyrosine kinase receptors on endothelial cell membrane promoting…”
Get full text

Hypoxia inducible factor 1α and 2α overexpression in inflammatory bowel disease by Giatromanolaki, A, Sivridis, E, Maltezos, E, Papazoglou, D, Simopoulos, C, Gatter, K C, Harris, A L, Koukourakis, M I

“…Aims: Hypoxia inducible factors 1α and 2α (HIF1α and HIF2α) are hypoxia regulated transcriptional factors, which control the expression of a variety of genes…”
Get full text

Proliferative activity in postmenopausal endometrium: the lurking potential for giving rise to an endometrial adenocarcinoma by Sivridis, E, Giatromanolaki, A

“…Aims: To investigate proliferation in disease free postmenopausal endometrium and that harbouring endometrial adenocarcinoma—is there a dynamic, yet lurking,…”
Get full text

Mechanical characterization of bone graft substitute ceramic cements by Drosos, G.I, Babourda, E, Magnissalis, E.A, Giatromanolaki, A, Kazakos, K, Verettas, D.A

“…Abstract The aim of this laboratory work was to study the compressive and flexural characteristics of various commercially available bone graft substitute…”
Get full text

Presentation of a patient with in situ amelanotic melanoma of the vulva by Tsikouras, P, Galazios, G, Tsagias, N, Koukoulomati, A, Romanidis, K, Giatromanolaki, A, Sivridis, E

“…Amelanotic malignant melanoma of the vulva is extremely rare. The authors describe here a case of amelanotic malignant melanoma of the vulva, occurring in a…”
Get more information

BNIP3 Expression Is Linked with Hypoxia-Regulated Protein Expression and with Poor Prognosis in Non–Small Cell Lung Cancer by GIATROMANOLAKI, Alexandra, KOUKOURAKIS, Michael I, SOWTER, Heidi M, SIVRIDIS, Efthimios, GIBSON, Spencer, GATTER, Kevin C, HARRIS, Adrian L

“…BNIP3 is a proapoptotic protein regulated by hypoxia-inducible factor 1. We analyzed BNIP3 expression in 105 tumor samples from early operable, non-small lung…”
Get full text

Vascular density analysis in colorectal cancer patients treated with vatalanib (PTK787/ZK222584) in the randomised CONFIRM trials by Giatromanolaki, A, Koukourakis, M I, Sivridis, E, Gatter, K C, Trarbach, T, Folprecht, G, Shi, M M, Lebwohl, D, Jalava, T, Laurent, D, Meinhardt, G, Harris, A L

“…Background: Pharmacological inhibitors of vascular endothelial growth factor (VEGF) receptors, like vatalanib, have been tested in randomised trials (CONFIRM…”
Get full text