Search Results - "Giaretti, Walter"

DNA aneuploidy relationship with patient age and tobacco smoke in OPMDs/OSCCs by Castagnola, Patrizio, Gandolfo, Sergio, Malacarne, Davide, Aiello, Cinzia, Marino, Roberto, Zoppoli, Gabriele, Ballestrero, Alberto, Giaretti, Walter, Pentenero, Monica

“…The aim of this study was to investigate the relationship between tobacco smoke habit, patient age, DNA aneuploidy and genomic DNA copy number aberrations…”
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Genomic DNA Copy Number Aberrations, Histological Diagnosis, Oral Subsite and Aneuploidy in OPMDs/OSCCs by Castagnola, Patrizio, Zoppoli, Gabriele, Gandolfo, Sergio, Monticone, Massimiliano, Malacarne, Davide, Cirmena, Gabriella, Brown, David, Aiello, Cinzia, Maffei, Massimo, Marino, Roberto, Giaretti, Walter, Pentenero, Monica

“…Oral potentially malignant disorders (OPMDs) characterized by the presence of dysplasia and DNA copy number aberrations (CNAs), may reflect chromosomal…”
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NAC, tiron and trolox impair survival of cell cultures containing glioblastoma tumorigenic initiating cells by inhibition of cell cycle progression by Monticone, Massimiliano, Taherian, Razieh, Stigliani, Sara, Carra, Elisa, Monteghirfo, Stefano, Longo, Luca, Daga, Antonio, Dono, Mariella, Zupo, Simona, Giaretti, Walter, Castagnola, Patrizio

“…Reactive oxygen species (ROS) are metabolism by-products that may act as signaling molecules to sustain tumor growth. Antioxidants have been used to impair…”
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Mutant KRAS, chromosomal instability and prognosis in colorectal cancer by Castagnola, Patrizio, Giaretti, Walter

“…The RAS gene family provides a global effect on gene expression by encoding small GTP-binding proteins which act as molecular switches connecting extracellular…”
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Gene expression deregulation by KRAS G12D and G12V in a BRAF V600E context by Monticone, Massimiliano, Biollo, Emanuela, Maffei, Massimo, Donadini, Alessandra, Romeo, Francesco, Storlazzi, Clelia Tiziana, Giaretti, Walter, Castagnola, Patrizio

“…KRAS and BRAF mutations appear of relevance in the genesis and progression of several solid tumor types but the co-occurrence and interaction of these…”
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Chromosomal aberrations and aneuploidy in oral potentially malignant lesions: distinctive features for tongue by Castagnola, Patrizio, Malacarne, Davide, Scaruffi, Paola, Maffei, Massimo, Donadini, Alessandra, Di Nallo, Emanuela, Coco, Simona, Tonini, Gian Paolo, Pentenero, Monica, Gandolfo, Sergio, Giaretti, Walter

“…The mucosae of the oral cavity are different at the histological level but appear all equally exposed to common genotoxic agents. As a result of this exposure,…”
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z-Leucinyl-Leucinyl-Norleucinal Induces Apoptosis of Human Glioblastoma Tumor–Initiating Cells by Proteasome Inhibition and Mitotic Arrest Response by Monticone, Massimiliano, Biollo, Emanuela, Fabiano, Andrea, Fabbi, Marina, Daga, Antonio, Romeo, Francesco, Maffei, Massimo, Melotti, Alice, Giaretti, Walter, Corte, Giorgio, Castagnola, Patrizio

“…γ-secretase inhibitors have been proposed as drugs able to kill cancer cells by targeting the NOTCH pathway. Here, we investigated two of such inhibitors, the…”
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Field effect in oral precancer as assessed by DNA flow cytometry and array-CGH by Pentenero, Monica, Donadini, Alessandra, Di Nallo, Emanuela, Maffei, Massimo, Marino, Roberto, Familiari, Ubaldo, Castagnola, Patrizio, Gandolfo, Sergio, Giaretti, Walter

“…J Oral Pathol Med (2012) 41: 119–123 Objective:  ‘Field cancerization’ is an accepted model for oral carcinogenesis. So far, genetically altered fields have…”
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Identification of a novel set of genes reflecting different in vivo invasive patterns of human GBM cells by Monticone, Massimiliano, Daga, Antonio, Candiani, Simona, Romeo, Francesco, Mirisola, Valentina, Viaggi, Silvia, Melloni, Ilaria, Pedemonte, Simona, Zona, Gianluigi, Giaretti, Walter, Pfeffer, Ulrich, Castagnola, Patrizio

“…Most patients affected by Glioblastoma multiforme (GBM, grade IV glioma) experience a recurrence of the disease because of the spreading of tumor cells beyond…”
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Chromosome 20 aberrations at the diploid-aneuploid transition in sporadic colorectal cancer by Maffei, Massimo, Mongera, Sandra, Terpstra, Libia, Donadini, Alessandra, Voorham, Quirinus J M, Meijer, Gerrit A, Giaretti, Walter, Carvalho, Beatriz, Castagnola, Patrizio

“…DNA aneuploid sublines in sporadic colorectal cancers (CRCs) are quite frequent (about 85%) and likely the consequence of chromosomal instability and DNA copy…”
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Vanishing conflicts on cancer theories by Giaretti, Walter

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Oral cancer genesis and progression: DNA near-diploid aneuploidization and endoreduplication by high resolution flow cytometry by Donadini, Alessandra, Maffei, Massimo, Cavallero, Antonio, Pentenero, Monica, Malacarne, Davide, Di Nallo, Emanuela, Truini, Mauro, Navone, Roberto, Mereu, Paola, Scala, Marco, Santelli, Alida, Gandolfo, Sergio, Giaretti, Walter

“…Oral potentially malignant lesions (OPMLs) with dysplasia and aneuploidy are thought to have a high risk of progression into oral squamous cell carcinomas…”
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The value of pretreatment cell kinetic parameters as predictors for radiotherapy outcome in head and neck cancer: a multicenter analysis by Begg, Adrian C., Haustermans, Karin, Hart, August A.M., Dische, Stan, Saunders, Michele, Zackrisson, Bjorn, Gustaffson, Hans, Coucke, Philippe, Paschoud, Nicolas, Hoyer, Morten, Overgaard, Jens, Antognoni, Paolo, Richetti, Antonella, Bourhis, Jean, Bartelink, Harry, Horiot, Jean-Claude, Corvo, Renzo, Giaretti, Walter, Awwad, Hassan, Shouman, Tarek, Jouffroy, Thomas, Maciorowski, Zofia, Dobrowsky, Werner, Struikmans, Henk, Rutgers, Derk, Wilson, George D.

“…Purpose: The aim of this study was to assess the potential of pre-treatment cell kinetic parameters to predict outcome in head and neck cancer patients treated…”
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Promoter methylation precedes chromosomal alterations in colorectal cancer development by Derks, Sarah, Postma, Cindy, Moerkerk, Peter T M, van den Bosch, Sandra M, Carvalho, Beatriz, Hermsen, Mario A J A, Giaretti, Walter, Herman, James G, Weijenberg, Matty P, de Bruïne, Adriaan P, Meijer, Gerrit A, van Engeland, Manon

“…Colorectal cancers are characterized by genetic and epigenetic alterations. This study aimed to explore the timing of promoter methylation and relationship…”
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KRAS, p53 and BRAF gene mutations and aneuploidy in sporadic colorectal cancer progression by Calistri, Daniele, Rengucci, Claudia, Seymour, Ian, Leonardi, Elena, Truini, Mauro, Malacarne, Davide, Castagnola, Patrizio, Giaretti, Walter

“…The origin and mechanisms of chromosomal instability are still widely unknown. We previously investigated a limited number of human sporadic colorectal cancers…”
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Chromosomal instability, aneuploidy, and gene mutations in human sporadic colorectal adenomas by Giaretti, Walter, Molinu, Silvia, Ceccarelli, Jenny, Prevosto, Claudia

“…Whether in vivo specific gene mutations lead to chromosomal instability (CIN) and aneuploidy or viceversa is so far not proven. We hypothesized that aneuploidy…”
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KRAS transitions and villous growth in colorectal adenomas by Risio, Mauro, Malacarne, Davide, Giaretti, Walter

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Consensus Report of the Task Force on Standardisation of DNA Flow Cytometry in Clinical Pathology by Ormerod, M. G., Tribukait, B., Giaretti, Walter

“…Guidelines are given to assist the standardisation of DNA flow cytometry in clinical pathology. They have been agreed by a group of twelve scientists from nine…”
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Chromosomal Instability, DNA Index, Dysplasia, and Subsite in Oral Premalignancy as Intermediate Endpoints of Risk of Cancer by GIARETTI, Walter, MONTEGHIRFO, Stefano, PENTENERO, Monica, GANDOLFO, Sergio, MALACARNE, Davide, CASTAGNOLA, Patrizio

“…Chromosomal instability and aneuploidy may represent biomarkers of oral exposure to damaging agents and early signs of clinical disease according to the theory…”
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Aneuploidy mechanisms in human colorectal preneoplastic lesions and Barrett's esophagus. Is there a role for K-ras and p53 mutations? by Giaretti, W

“…The link of aneuploidy and heteroploidy in human solid tumours with early genetic events is poorly understood. The study of human preneoplastic precursor…”
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