Search Results - "Giardina, F"

Models of benthic bipedalism by Giardina, F, Mahadevan, L

“…Walking is a common bipedal and quadrupedal gait and is often associated with terrestrial and aquatic organisms. Inspired by recent evidence of the neural…”
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Association of survival and disease progression with chromosomal instability: A genomic exploration of colorectal cancer by Sheffer, Michal, Bacolod, Manny D, Zuk, Or, Giardina, Sarah F, Pincas, Hanna, Barany, Francis, Paty, Philip B, Gerald, William L, Notterman, Daniel A, Domany, Eytan

“…During disease progression the cells that comprise solid malignancies undergo significant changes in gene copy number and chromosome structure. Colorectal…”
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Prediction of blood-based biomarkers and subsequent design of bisulfite PCR-LDR-qPCR assay for breast cancer detection by Bacolod, Manny D, Huang, Jianmin, Giardina, Sarah F, Feinberg, Philip B, Mirza, Aashiq H, Swistel, Alexander, Soper, Steven A, Barany, Francis

“…Interrogation of site-specific CpG methylation in circulating tumor DNAs (ctDNAs) has been employed in a number of studies for early detection of breast cancer…”
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COVID-19 in Italian Sjögren's syndrome patients: a monocentric study by Giardina, F., Izzo, R., Gattamelata, A., Colafrancesco, S., Conti, F., Priori, R.

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Application of Multiplex Bisulfite PCR–Ligase Detection Reaction–Real-Time Quantitative PCR Assay in Interrogating Bioinformatically Identified, Blood-Based Methylation Markers for Colorectal Cancer by Bacolod, Manny D., Mirza, Aashiq H., Huang, Jianmin, Giardina, Sarah F., Feinberg, Philip B., Soper, Steven A., Barany, Francis

“…The analysis of CpG methylation in circulating tumor DNA fragments has emerged as a promising approach for the noninvasive early detection of solid tumors,…”
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Are Sunken Warships Biodiversity Havens for Corals? by Asner, Gregory P., Giardina, Sonja F., Balzotti, Christopher, Drury, Crawford, Hopson, Sean, Martin, Roberta E.

“…Coral reefs are threatened by climate change, overfishing, and pollution. Artificial reefs may provide havens for corals, both to escape warming surface waters…”
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Submesoscale‐Permitting Physical/Biogeochemical Future Projections for the Main Hawaiian Islands by Friedrich, T., Powell, B. S., Gunnarson, J. L., Liu, G., Giardina, S. F., Stuecker, M. F., Hošeková, L., Feloy, K., Stock, C. A.

“…Global climate models provide useful tools to forecast large‐scale anthropogenic trends and the impacts on ocean physics and marine biology and chemistry. Due…”
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SARS-CoV-2 infection in patients with primary Sjögren syndrome: characterization and outcomes of 51 patients by Brito-Zerón, Pilar, Melchor, Sheila, Seror, Raphaèle, Priori, Roberta, Solans, Roser, Kostov, Belchin, Baldini, Chiara, Carubbi, Francesco, Callejas, Jose Luis, Guisado-Vasco, Pablo, Hernández-Molina, Gabriela, Pasoto, Sandra G, Valim, Valeria, Sisó-Almirall, Antoni, Mariette, Xavier, Carreira, Patricia, Ramos-Casals, Manuel

“…Abstract Objective To analyse the prognosis and outcomes of SARS-CoV-2 infection in patients with primary SS. Methods We searched for patients with primary SS…”
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Outbreak of measles genotype H1 in Northern Italy originated from a case imported from Southeast Asia, 2017 by Rovida, F., Brianese, N., Piralla, A., Sarasini, A., Girello, A., Giardina, F., Cassaniti, I., Fornabaio, C., Seminari, E., Monteverdi, A., Piro, A., Baggieri, M., Cereda, D., Pan, A., Magurano, F., Baldanti, F.

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Connexin 43 confers resistance to hydrogen peroxide-mediated apoptosis by Giardina, Sarah F, Mikami, Maya, Goubaeva, Farida, Yang, Jay

“…The current study aimed to understand the anti-apoptotic effect of overexpressed gap junction forming protein connexin (Cx) 43 in C6 glioma cells. C6 cells…”
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The silver-cheeked toadfish Lagocephalus sceleratus (Gmelin, 1789) reaches Italian waters by Azzurro, E., Castriota, L., Falautano, M., Giardina, F., Andaloro, F.

“…According to the available literature, the current distribution limits of L. sceleratus correspond to the north Aegean Sea and Tunisia, whilst this species has…”
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CpG Island Methylator Phenotype Associates with Low-Degree Chromosomal Abnormalities in Colorectal Cancer by Cheng, Yu-Wei, Pincas, Hanna, Bacolod, Manny D, Schemmann, Gunter, Giardina, Sarah F, Huang, Jianmin, Barral, Sandra, Idrees, Kamran, Khan, Sajid A, Zeng, Zhaoshi, Rosenberg, Shoshana, Notterman, Daniel A, Ott, Jurg, Paty, Philip, Barany, Francis

“…Purpose: Aberrant promoter methylation and genomic instability occur frequently during colorectal cancer development. CpG island methylator phenotype (CIMP)…”
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A Novel, Nonpeptidic, Orally Active Bivalent Inhibitor of Human β-Tryptase by Giardina, Sarah F, Werner, Douglas S, Pingle, Maneesh, Bergstrom, Donald E, Arnold, Lee D, Barany, Francis

“…β-Tryptase is released from mast cells upon degranulation in response to allergic and inflammatory stimuli. Human tryptase is a homotetrameric serine protease…”
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Emerging Paradigms in Cancer Genetics: Some Important Findings from High-Density Single Nucleotide Polymorphism Array Studies by BACOLOD, Manny D, SCHEMMANN, Gunter S, GIARDINA, Sarah F, PATY, Philip, NOTTERMAN, Daniel A, BARANY, Francis

“…High-density single nucleotide polymorphism (SNP) mapping arrays have identified chromosomal features whose importance to cancer predisposition and progression…”
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GROα Is Highly Expressed in Adenocarcinoma of the Colon and Down-Regulates Fibulin-1 by YU WEN, GIARDINA, Sarah F, PATY, Phillip, GERALD, William, NOTTERMAN, Daniel, HAMMING, David, GREENMAN, Jennifer, ZACHARIAH, Emmanuel, BACOLOD, Manny D, HAO LIU, SHIA, Jinru, AMENTA, Peter S, BARANY, Francis

“…Purpose: The growth-related oncogene α (GROα) is a secreted interleukin-like molecule that interacts with the CXCR2 G-protein–coupled receptor. We found that…”
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Reversible Assembly of Proteolysis Targeting Chimeras by Gui, Weijun, Giardina, Sarah F., Balzarini, Madeline, Barany, Francis, Kodadek, Thomas

“…PROteolysis TArgeting Chimeras (PROTACs) are of significant current interest for the development of probe molecules and drug leads. However, they suffer from…”
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Micromolar l-glutamate induces extensive apoptosis in an apoptotic-necrotic continuum of insult-dependent, excitotoxic injury in cultured cortical neurones by Cheung, Nam S, Pascoe, Catherine J, Giardina, Sarah F, John, Christopher A, Beart, Philip M

“…Excitotoxicity induced by l-glutamate (Glu), when examined in a pure neuronal cortical culture, involved widespread apoptosis at concentrations of 1–10 μM as…”
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Combinatorial Ubiquitination REal-time PROteolysis (CURE-PROs): A Modular Platform for Generating Reversible, Self-Assembling Bifunctional Targeted Degraders by Giardina, Sarah F., Valdambrini, Elena, Singh, Pradeep K., Bacolod, Manny D., Babu-Karunakaran, Ganesh, Peel, Michael, Warren, J. David, Barany, Francis

“…Proteolysis-Targeting Chimeras (PROTACs) are bifunctional molecules that bring a target protein and an E3 ubiquitin ligase into proximity to append ubiquitin,…”
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Novel, Self-Assembling Dimeric Inhibitors of Human β Tryptase by Giardina, Sarah F, Werner, Douglas S, Pingle, Maneesh, Feinberg, Philip B, Foreman, Kenneth W, Bergstrom, Donald E, Arnold, Lee D, Barany, Francis

“…β-Tryptase, a homotetrameric serine protease, has four identical active sites facing a central pore, presenting an optimized setting for the rational design of…”
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Single‐molecule detection of cancer mutations using a novel PCR‐LDR‐qPCR assay by Ruiz, Cristian, Huang, Jianmin, Giardina, Sarah F., Feinberg, Philip B., Mirza, Aashiq H., Bacolod, Manny D., Soper, Steven A., Barany, Francis

“…ABSTRACT Detection of low‐abundance mutations in cell‐free DNA is being used to identify early cancer and early cancer recurrence. Here, we report a new…”
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