Search Results - "Gianotti, Andréia"

Inhibitory effect of the sugarcane cystatin CaneCPI-4 on cathepsins B and L and human breast cancer cell invasion by Gianotti, Andréia, Sommer, César A, Carmona, Adriana K, Henrique-Silva, Flávio

“…The lysosomal cysteine proteases cathepsin B and L play important roles in tumor cell invasion. An imbalance between these cathepsins and their endogenous…”
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Generation of Transgene‐Free Lung Disease‐Specific Human Induced Pluripotent Stem Cells Using a Single Excisable Lentiviral Stem Cell Cassette by Somers, Aba, Jean, Jyh‐Chang, Sommer, Cesar A., Omari, Amel, Ford, Christopher C., Mills, Jason A., Ying, Lei, Sommer, Andreia Gianotti, Jean, Jenny M., Smith, Brenden W., Lafyatis, Robert, Demierre, Marie‐France, Weiss, Daniel J., French, Deborah L., Gadue, Paul, Murphy, George J., Mostoslavsky, Gustavo, Kotton, Darrell N.

“…The development of methods to achieve efficient reprogramming of human cells while avoiding the permanent presence of reprogramming transgenes represents a…”
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FSP27 and PLIN1 interaction promotes the formation of large lipid droplets in human adipocytes by Grahn, Tan Hooi Min, Zhang, Yan, Lee, Mi-Jeong, Sommer, Andreia Gianotti, Mostoslavsky, Gustavo, Fried, Susan K., Greenberg, Andrew S., Puri, Vishwajeet

“…► FSP27 interacts with PLIN1, and aa 120–220 of FSP27 play a role in this interaction. ► FSP27 and PLIN1 co-localize at the lipid droplet surface in human…”
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Recombinant expression, purification, and functional analysis of two novel cystatins from sugarcane ( Saccharum officinarum) by Gianotti, Andréia, Rios, Wendy M., Soares-Costa, Andrea, Nogaroto, Viviane, Carmona, Adriana K., Oliva, Maria L.V., Andrade, Sheila S., Henrique-Silva, Flávio

“…Phytocystatins are cysteine proteinase inhibitors from plants implicated in the endogenous regulation of protein turnover, programmed cell death, and in…”
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Differential Association of Chromatin Proteins Identifies BAF60a/SMARCD1 as a Regulator of Embryonic Stem Cell Differentiation by Alajem, Adi, Biran, Alva, Harikumar, Arigela, Sailaja, Badi Sri, Aaronson, Yair, Livyatan, Ilana, Nissim-Rafinia, Malka, Sommer, Andreia Gianotti, Mostoslavsky, Gustavo, Gerbasi, Vincent R., Golden, Daniel E., Datta, Arnab, Sze, Siu Kwan, Meshorer, Eran

“…Embryonic stem cells (ESCs) possess a distinct chromatin conformation maintained by specialized chromatin proteins. To identify chromatin regulators in ESCs,…”
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Recombinant expression and characterization of a Xylella fastidiosa cysteine protease differentially expressed in a nonpathogenic strain by Nogaroto, Viviane, Tagliavini, SandraA, Gianotti, Andréia, Mikawa, Angela, Barros, NilanaM.T., Puzer, Luciano, Carmona, Adriana K., Costa, PauloI, Henrique-Silva, Flávio

“…Abstract Xylella fastidiosa is a xylem-limited, Gram-negative bacterium responsible for citrus variegated chlorosis (CVC) in sweet oranges. In the present…”
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Insulin-like growth factor 2 modulates murine hematopoietic stem cell maintenance through upregulation of p57 by Thomas, Dolly D, Sommer, Andreia Gianotti, Balazs, Alejandro B, Beerman, Isabel, Murphy, George J, Rossi, Derrick, Mostoslavsky, Gustavo

“…Hematopoietic stem cells (HSC) rely on a highly regulated molecular network to balance self-renewal and lineage specification to sustain life-long…”
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Modeling APC mutagenesis and familial adenomatous polyposis using human iPS cells by Sommer, Cesar A, Capilla, Amalia, Molina-Estevez, Francisco J, Gianotti-Sommer, Andreia, Skvir, Nicholas, Caballero, Ignacio, Chowdhury, Sanjib, Mostoslavsky, Gustavo

“…Mutations in the gene Adenomatous Polyposis Coli or APC appear in most sporadic cases of colorectal cancer and it is the most frequent mutation causing…”
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Residual expression of reprogramming factors affects the transcriptional program and epigenetic signatures of induced pluripotent stem cells by Sommer, Cesar A, Christodoulou, Constantina, Gianotti-Sommer, Andreia, Shen, Steven S, Sailaja, Badi Sri, Hezroni, Hadas, Spira, Avrum, Meshorer, Eran, Kotton, Darrell N, Mostoslavsky, Gustavo

“…Delivery of the transcription factors Oct4, Klf4, Sox2 and c-Myc via integrating viral vectors has been widely employed to generate induced pluripotent stem…”
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A Comprehensive, Ethnically Diverse Library of Sickle Cell Disease-Specific Induced Pluripotent Stem Cells by Park, Seonmi, Gianotti-Sommer, Andreia, Molina-Estevez, Francisco Javier, Vanuytsel, Kim, Skvir, Nick, Leung, Amy, Rozelle, Sarah S., Shaikho, Elmutaz Mohammed, Weir, Isabelle, Jiang, Zhihua, Luo, Hong-Yuan, Chui, David H.K., Figueiredo, Maria Stella, Alsultan, Abdulraham, Al-Ali, Amein, Sebastiani, Paola, Steinberg, Martin H., Mostoslavsky, Gustavo, Murphy, George J.

“…Sickle cell anemia affects millions of people worldwide and is an emerging global health burden. As part of a large NIH-funded NextGen Consortium, we generated…”
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Excision of Reprogramming Transgenes Improves the Differentiation Potential of iPS Cells Generated with a Single Excisable Vector by Sommer, Cesar A., Sommer, Andreia Gianotti, Longmire, Tyler A., Christodoulou, Constantina, Thomas, Dolly D., Gostissa, Monica, Alt, Fred W., Murphy, George J., Kotton, Darrell N., Mostoslavsky, Gustavo

“…The residual presence of integrated transgenes following the derivation of induced pluripotent stem (iPS) cells is highly undesirable. Here we demonstrate…”
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Lineage conversion induced by pluripotency factors involves transient passage through an iPS cell stage by Bar-Nur, Ori, Verheul, Cassandra, Sommer, Andreia Gianotti, Brumbaugh, Justin, Schwarz, Benjamin A., Lipchina, Inna, Huebner, Aaron J., Mostoslavsky, Gustavo, Hochedlinger, Konrad

“…Brief expression of pluripotency-associated factors such as Oct4, Klf4, Sox2 and c-Myc (OKSM), in combination with differentiation-inducing signals, was…”
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Multisystem, Induced Pluripotent Stem Cell (iPSC) Modeling Reveals a Role for Growth Differentiation Factors (GDFs) in the Etiology of β Thalassemia and Ineffective Erythropoiesis by Wang, Liz B., Sommer, Andreia Gianotti, Leung, Amy, Park, Seonmi, Chui, David H.K., Steinberg, Martin H., Mostoslavsky, Gustavo, Murphy, George J.

“…β Thalassemia is one of the most common monogenic diseases in man encompassing a heterogeneous group of naturally occurring, inherited mutations characterized…”
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Generation of human induced pluripotent stem cells from peripheral blood using the STEMCCA lentiviral vector by Sommer, Andreia Gianotti, Rozelle, Sarah S, Sullivan, Spencer, Mills, Jason A, Park, Seon-Mi, Smith, Brenden W, Iyer, Amulya M, French, Deborah L, Kotton, Darrell N, Gadue, Paul, Murphy, George J, Mostoslavsky, Gustavo

“…Through the ectopic expression of four transcription factors, Oct4, Klf4, Sox2 and cMyc, human somatic cells can be converted to a pluripotent state,…”
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The crystal structure of the cysteine protease Xylellain from Xylella fastidiosa reveals an intriguing activation mechanism by Leite, Ney Ribeiro, Faro, Aline Regis, Dotta, Maria Amélia Oliva, Faim, Livia Maria, Gianotti, Andreia, Silva, Flavio Henrique, Oliva, Glaucius, Thiemann, Otavio Henrique

“…► The plant pathogen Xylella fastidiosa has a single cysteine protease, Xylellain. ► Xylellain crystallographic structure was solved at 1.65Å resolution. ► A…”
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24 Modeling Familial Adenomatous Polyposis With Induced Pluripotent Stem Cells by Sommer, Cesar, Gianotti-Sommer, Andreia, Mostoslavsky, Gustavo

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Generation of Human Induced Pluripotent Stem Cells from Peripheral Blood Using the STEMCCA Lentiviral Vector by Sommer, Andreia Gianotti, Rozelle, Sarah S., Sullivan, Spencer, Mills, Jason A., Park, Seon-Mi, Smith, Brenden W., Iyer, Amulya M., French, Deborah L., Kotton, Darrell N., Gadue, Paul, Murphy, George J., Mostoslavsky, Gustavo

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403 Modeling Gastrointestinal and Liver Genetic Diseases Using Induced Pluripotent Stem Cells by Gianotti-Sommer, Andreia, Sommer, Cesar, Mostoslavsky, Gustavo

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A Library of Sickle Cell Anemia Induced Pluripotent Stem Cells of Diverse Haplotypes and Ethnicities by Park, Seonmi, Gianotti-Sommer, Andreia, Chui, David H.K., Figueiredo, Maria Stella, Alsultan, Abdulrahman, Al-Ali, Amein, Steinberg, Martin H, Murphy, George J., Mostoslavsky, Gustavo

“…The mutation causing sickle cell anemia (rs334, GAG-GTG, glu6val) had several independent origins in Africa, the Middle East and India and spread throughout…”
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