Search Results - "Giannoukakis, Nick"

Tolerogenic dendritic cells in type 1 diabetes: no longer a concept by Giannoukakis, Nick

“…Tolerogenic dendritic cells (tDC) arrest the progression of autoimmune-driven dysglycemia into clinical, insulin-requiring type 1 diabetes (T1D) and preserve a…”
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Phase I (Safety) Study of Autologous Tolerogenic Dendritic Cells in Type 1 Diabetic Patients by Giannoukakis, Nick, Phillips, Brett, Finegold, David, Harnaha, Jo, Trucco, Massimo

“…OBJECTIVE: The safety of dendritic cells to selectively suppress autoimmunity, especially in type 1 diabetes, has never been ascertained. We investigated the…”
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Clinical Tolerogenic Dendritic Cells: Exploring Therapeutic Impact on Human Autoimmune Disease by Phillips, Brett Eugene, Garciafigueroa, Yesica, Trucco, Massimo, Giannoukakis, Nick

“…Tolerogenic dendritic cell (tDC)-based clinical trials for the treatment of autoimmune diseases are now a reality. Clinical trials are currently exploring the…”
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Evaluation of ranirestat for the treatment of diabetic neuropathy by Giannoukakis, Nick

“…Pharmacologic maintenance of normoglycemia in diabetes cannot prevent the eventual complications mainly due to protein glycation-induced cell death,…”
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Editorial: Diabetes and non-alcoholic fatty liver disease: points of physiological and mechanistic intersection and current co-therapeutic approaches by Giannoukakis, Nick, McCommis, Kyle S

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Tolerogenic Dendritic Cells and T-Regulatory Cells at the Clinical Trials Crossroad for the Treatment of Autoimmune Disease; Emphasis on Type 1 Diabetes Therapy by Phillips, Brett Eugene, Garciafigueroa, Yesica, Engman, Carl, Trucco, Massimo, Giannoukakis, Nick

“…Tolerogenic dendritic cells and T-regulatory cells are two immune cell populations with the potential to prevent the onset of clinical stage type 1 diabetes,…”
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Autoimmune Inflammation and Insulin Resistance: Hallmarks So Far and Yet So Close to Explain Diabetes Endotypes by Petrelli, Alessandra, Giovenzana, Anna, Insalaco, Vittoria, Phillips, Brett E., Pietropaolo, Massimo, Giannoukakis, Nick

“…Purpose of Review Diabetes mellitus can be categorized into two major variants, type 1 and type 2. A number of traits such as clinical phenotype, age at…”
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Uncoupling hepatic insulin resistance - hepatic inflammation to improve insulin sensitivity and to prevent impaired metabolism-associated fatty liver disease in type 2 diabetes by Niranjan, Sitara, Phillips, Brett E, Giannoukakis, Nick

“…Diabetes mellitus is a metabolic disease clinically-characterized as acute and chronic hyperglycemia. It is emerging as one of the common conditions associated…”
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Improvement in insulin sensitivity and prevention of high fat diet-induced liver pathology using a CXCR2 antagonist by Phillips, Brett E, Lantier, Louise, Engman, Carl, Garciafigueroa, Yesica, Singhi, Aatur, Trucco, Massimo, Mantzoros, Christos, Wasserman, David, Giannoukakis, Nick

“…Liver pathology (LP) characteristic of non-alcoholic fatty acid disease (NAFLD)/non-alcoholic steatohepatitis (NASH) is a prevalent co-morbidity of type 2…”
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Involvement of suppressive B-lymphocytes in the mechanism of tolerogenic dendritic cell reversal of type 1 diabetes in NOD mice by Di Caro, Valentina, Phillips, Brett, Engman, Carl, Harnaha, Jo, Trucco, Massimo, Giannoukakis, Nick

“…The objective of the study was to identify immune cell populations, in addition to Foxp3+ T-regulatory cells, that participate in the mechanisms of action of…”
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FoxO1 Links Insulin Resistance to Proinflammatory Cytokine IL-1β Production in Macrophages by Su, Dongming, Coudriet, Gina M., Hyun Kim, Dae, Lu, Yi, Perdomo, German, Qu, Shen, Slusher, Sandra, Tse, Hubert M., Piganelli, Jon, Giannoukakis, Nick, Zhang, Jian, Henry Dong, H.

“…FoxO1 Links Insulin Resistance to Proinflammatory Cytokine IL-1β Production in Macrophages Dongming Su 1 , Gina M. Coudriet 1 , Dae Hyun Kim 1 , Yi Lu 2 ,…”
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Neutrophil-Associated Inflammatory Changes in the Pre-Diabetic Pancreas of Early-Age NOD Mice by Garciafigueroa, Yesica, Phillips, Brett E, Engman, Carl, Trucco, Massimo, Giannoukakis, Nick

“…A growing body of evidence indicates that neutrophils are the first major leukocyte population accumulating inside the pancreas even before the onset of a…”
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Arrest in the Progression of Type 1 Diabetes at the Mid-Stage of Insulitic Autoimmunity Using an Autoantigen-Decorated All- trans Retinoic Acid and Transforming Growth Factor Beta-1 Single Microparticle Formulation by Phillips, Brett E, Garciafigueroa, Yesica, Engman, Carl, Liu, Wen, Wang, Yiwei, Lakomy, Robert J, Meng, Wilson S, Trucco, Massimo, Giannoukakis, Nick

“…Type 1 diabetes (T1D) is a disorder of impaired glucoregulation due to lymphocyte-driven pancreatic autoimmunity. Mobilizing dendritic cells (DC) to acquire…”
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Co-Stimulation-Impaired Bone Marrow-Derived Dendritic Cells Prevent Dextran Sodium Sulfate-Induced Colitis in Mice by Engman, Carl, Garciafigueroa, Yesica, Phillips, Brett Eugene, Trucco, Massimo, Giannoukakis, Nick

“…Dendritic cells (DC) are important in the onset and severity of inflammatory bowel disease (IBD). Tolerogenic DC induce T-cells to become therapeutic Foxp3+…”
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It's time to bring dendritic cell therapy to type 1 diabetes by Creusot, Rémi J, Giannoukakis, Nick, Trucco, Massimo, Clare-Salzler, Michael J, Fathman, C Garrison

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Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization by Fuchs, Anke, Gliwiński, Mateusz, Grageda, Nathali, Spiering, Rachel, Abbas, Abul K, Appel, Silke, Bacchetta, Rosa, Battaglia, Manuela, Berglund, David, Blazar, Bruce, Bluestone, Jeffrey A, Bornhäuser, Martin, Ten Brinke, Anja, Brusko, Todd M, Cools, Nathalie, Cuturi, Maria Cristina, Geissler, Edward, Giannoukakis, Nick, Gołab, Karolina, Hafler, David A, van Ham, S Marieke, Hester, Joanna, Hippen, Keli, Di Ianni, Mauro, Ilic, Natasa, Isaacs, John, Issa, Fadi, Iwaszkiewicz-Grześ, Dorota, Jaeckel, Elmar, Joosten, Irma, Klatzmann, David, Koenen, Hans, van Kooten, Cees, Korsgren, Olle, Kretschmer, Karsten, Levings, Megan, Marek-Trzonkowska, Natalia Maria, Martinez-Llordella, Marc, Miljkovic, Djordje, Mills, Kingston H G, Miranda, Joana P, Piccirillo, Ciriaco A, Putnam, Amy L, Ritter, Thomas, Roncarolo, Maria Grazia, Sakaguchi, Shimon, Sánchez-Ramón, Silvia, Sawitzki, Birgit, Sofronic-Milosavljevic, Ljiljana, Sykes, Megan, Tang, Qizhi, Vives-Pi, Marta, Waldmann, Herman, Witkowski, Piotr, Wood, Kathryn J, Gregori, Silvia, Hilkens, Catharien M U, Lombardi, Giovanna, Lord, Phillip, Martinez-Caceres, Eva M, Trzonkowski, Piotr

“…Cellular therapies with CD4+ T regulatory cells (Tregs) hold promise of efficacious treatment for the variety of autoimmune and allergic diseases as well as…”
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Identification of a cardiac specific protein transduction domain by in vivo biopanning using a M13 phage peptide display library in mice by Zahid, Maliha, Phillips, Brett E, Albers, Sean M, Giannoukakis, Nick, Watkins, Simon C, Robbins, Paul D

“…A peptide able to transduce cardiac tissue specifically, delivering cargoes to the heart, would be of significant therapeutic potential for delivery of small…”
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Antisense Oligonucleotides Down-Regulating Costimulation Confer Diabetes-Preventive Properties to Nonobese Diabetic Mouse Dendritic Cells by Machen, Jennifer, Harnaha, Jo, Lakomy, Robert, Styche, Alexis, Trucco, Massimo, Giannoukakis, Nick

“…Phenotypically "immature" dendritic cells (DCs), defined by low cell surface CD40, CD80, and CD86 can elicit host immune suppression in allotransplantation and…”
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A Microsphere-Based Vaccine Prevents and Reverses New-Onset Autoimmune Diabetes by PHILLIPS, Brett, NYLANDER, Karen, KNOX, Janet, HOGELAND, Kenneth, TRUCCO, Massimo, GIANNOUKAKIS, Nick, HARNAHA, Jo, MACHEN, Jennifer, LAKOMY, Robert, STYCHE, Alexis, GILLIS, Kimberly, BROWN, Larry, LAFRENIERE, Debra, GALLO, Michael

“…A Microsphere-Based Vaccine Prevents and Reverses New-Onset Autoimmune Diabetes Brett Phillips 1 , Karen Nylander 1 , Jo Harnaha 1 , Jennifer Machen 1 , Robert…”
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Minimum information about tolerogenic antigen-presenting cells (MITAP): a first step towards reproducibility and standardisation of cellular therapies by Lord, Phillip, Spiering, Rachel, Aguillon, Juan C, Anderson, Amy E, Appel, Silke, Benitez-Ribas, Daniel, Ten Brinke, Anja, Broere, Femke, Cools, Nathalie, Cuturi, Maria Cristina, Diboll, Julie, Geissler, Edward K, Giannoukakis, Nick, Gregori, Silvia, van Ham, S Marieke, Lattimer, Staci, Marshall, Lindsay, Harry, Rachel A, Hutchinson, James A, Isaacs, John D, Joosten, Irma, van Kooten, Cees, Lopez Diaz de Cerio, Ascension, Nikolic, Tatjana, Oral, Haluk Barbaros, Sofronic-Milosavljevic, Ljiljana, Ritter, Thomas, Riquelme, Paloma, Thomson, Angus W, Trucco, Massimo, Vives-Pi, Marta, Martinez-Caceres, Eva M, Hilkens, Catharien M U

“…Cellular therapies with tolerogenic antigen-presenting cells (tolAPC) show great promise for the treatment of autoimmune diseases and for the prevention of…”
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