Search Results - "Giannone, Michael"

A Pilot Study of Galunisertib plus Stereotactic Body Radiotherapy in Patients with Advanced Hepatocellular Carcinoma by Reiss, Kim A, Wattenberg, Max M, Damjanov, Nevena, Prechtel Dunphy, Elizabeth, Jacobs-Small, Mona, Lubas, M Judy, Robinson, James, Dicicco, Lisa, Garcia-Marcano, Luis, Giannone, Michael A, Karasic, Thomas B, Furth, Emma E, Carpenter, Erica L, Wojcieszynski, Andrzej P, Vonderheide, Robert H, Beatty, Gregory L, Ben-Josef, Edgar

“…TGFβ is a pleiotropic cytokine with immunosuppressive activity. In preclinical models, blockade of TGFβ enhances the activity of radiation and invokes T-cell…”
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Systemic inflammation is a determinant of outcomes of CD40 agonist-based therapy in pancreatic cancer patients by Wattenberg, Max M, Herrera, Veronica M, Giannone, Michael A, Gladney, Whitney L, Carpenter, Erica L, Beatty, Gregory L

“…Agonistic anti-CD40 monoclonal antibody (mAb) therapy in combination with chemotherapy (chemoimmunotherapy) shows promise for the treatment of pancreatic…”
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TNF blockade uncouples toxicity from antitumor efficacy induced with CD40 chemoimmunotherapy by Stone, Meredith L, Lee, Jesse, Herrera, Veronica M, Graham, Kathleen, Lee, Jae W, Huffman, Austin, Coho, Heather, Tooker, Evan, Myers, Max I, Giannone, Michael, Li, Yan, Buckingham, Thomas H, Long, Kristen B, Beatty, Gregory L

“…Agonist CD40 antibodies are under clinical development in combination with chemotherapy as an approach to prime for antitumor T cell immunity. However,…”
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Driver Response Time in Cut-Off Scenarios from the Second Strategic Highway Research Program Naturalistic Database by Dinakar, Swaroop, Muttart, Jeffrey W., Edewaard, Darlene E., Giannone, Michael, Dickson, Connor

“…A cut-in or cut-off scenario involves a vehicle intruding into the path of another vehicle traveling in the same direction. These lane changes can lead to…”
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Peripheral blood immune correlates associated with TGF-β inhibition (galunisertib) and stereotactic body radiotherapy (SBRT) in patients with advanced hepatocellular carcinoma (HCC) by Wattenberg, Max Miller, Reiss, Kim Anna, Giannone, Michael, Damjanov, Nevena, Prechtel Dunphy, Elizabeth, DiCicco, Lisa, Garcia-Marcano, Luis, Karasic, Thomas Benjamin, Furth, Emma, Wojcieszynski, Andrzej, Vonderheide, Robert H., Ben-Josef, Edgar, Beatty, Gregory Lawrence

“…Abstract only 4575 Background: TGF-β is a pleiotropic cytokine with immunosuppressive activity. In mouse models, blockade of TGF-β signaling enhances the…”
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Abstract B030: Spatial coupling of microbes and immune cells shapes the tumor microenvironment in human cancers by Li, Yan, Chang, Renee B., Stone, Meredith L., Xue, Yuqing, Coho, Heather, Markowitz, Kelly, Patel, Dhruv, Herrera, Veronica M., Li, Joey H., Delman, Devora, Zhang, Liti, Choi-Bose, Shaanti, Giannone, Michael, Lee, Jae W., Beatty, Gregory

“…Abstract Microbes play a crucial role in the tumor microenvironment, yet the factors governing their presence within tumors remain poorly understood. In this…”
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Multimodal immune phenotyping reveals microbial-T cell interactions that shape pancreatic cancer by Li, Yan, Chang, Renee B., Stone, Meredith L., Delman, Devora, Markowitz, Kelly, Xue, Yuqing, Coho, Heather, Herrera, Veronica M., Li, Joey H., Zhang, Liti, Choi-Bose, Shaanti, Giannone, Michael, Shin, Sarah M., Coyne, Erin M., Hernandez, Alexei, Gross, Nicole E., Charmsaz, Soren, Ho, Won Jin, Lee, Jae W., Beatty, Gregory L.

“…Microbes are an integral component of the tumor microenvironment. However, determinants of microbial presence remain ill-defined. Here, using spatial-profiling…”
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Abstract C018: Co-activation of myeloid signaling pathways for pancreatic cancer immunotherapy by Wattenberg, Max M., Coho, Heather, Herrera, Veronica M., Graham, Kathleen, Stone, Meredith L., Xue, Yuqing, Chang, Renee B., Cassella, Christopher, Liu, Mingen, Choi-Bose, Shaanti, Thomas, Stacy K., Choi, Hana, Li, Yan, Melendez, Lauren, Giannone, Michael, Bose, Nandita, Beatty, Gregory L.

“…Abstract Pancreatic ductal adenocarcinoma (PDA) is characterized by a robust myeloid cell infiltrate. Although myeloid cells in PDA most commonly associate…”
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