Search Results - "Giannini, Heather"

A Diagnostic Sequence by Giannini, Heather M., Lee, Clement, Baston, Cameron, Dorgan, Daniel

“…A 42-year-old woman presented to the ED with a 3-day history of shortness of breath, fatigue, and cough productive of thick, yellow-green sputum. She also…”
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A Machine Learning Algorithm to Predict Severe Sepsis and Septic Shock: Development, Implementation, and Impact on Clinical Practice by Giannini, Heather M., Ginestra, Jennifer C., Chivers, Corey, Draugelis, Michael, Hanish, Asaf, Schweickert, William D., Fuchs, Barry D., Meadows, Laurie, Lynch, Michael, Donnelly, Patrick J., Pavan, Kimberly, Fishman, Neil O., Hanson, C. William, Umscheid, Craig A.

“…OBJECTIVES:Develop and implement a machine learning algorithm to predict severe sepsis and septic shock and evaluate the impact on clinical practice and…”
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Early Warning Systems for Critical Illness Outside the Intensive Care Unit by Henry, Katharine E., Giannini, Heather M.

“…Early warning systems (EWSs) are designed and deployed to create a rapid assessment and response for patients with clinical deterioration outside the intensive…”
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Clinician Perception of a Machine Learning–Based Early Warning System Designed to Predict Severe Sepsis and Septic Shock by Ginestra, Jennifer C., Giannini, Heather M., Schweickert, William D., Meadows, Laurie, Lynch, Michael J., Pavan, Kimberly, Chivers, Corey J., Draugelis, Michael, Donnelly, Patrick J., Fuchs, Barry D., Umscheid, Craig A.

“…OBJECTIVE:To assess clinician perceptions of a machine learning–based early warning system to predict severe sepsis and septic shock (Early Warning System…”
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Association of vancomycin plus piperacillin–tazobactam with early changes in creatinine versus cystatin C in critically ill adults: a prospective cohort study by Miano, Todd A., Hennessy, Sean, Yang, Wei, Dunn, Thomas G., Weisman, Ariel R., Oniyide, Oluwatosin, Agyekum, Roseline S., Turner, Alexandra P., Ittner, Caroline A. G., Anderson, Brian J., Wilson, F. Perry, Townsend, Raymond, Reilly, John P., Giannini, Heather M., Cosgriff, Christopher V., Jones, Tiffanie K., Meyer, Nuala J., Shashaty, Michael G. S.

“…Purpose Although dozens of studies have associated vancomycin + piperacillin–tazobactam with increased acute kidney injury (AKI) risk, it is unclear whether…”
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Genetics of Acute Respiratory Distress Syndrome: Pathways to Precision by Giannini, Heather M, Meyer, Nuala J

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New-onset IgG autoantibodies in hospitalized patients with COVID-19 by Chang, Sarah Esther, Feng, Allan, Meng, Wenzhao, Apostolidis, Sokratis A., Mack, Elisabeth, Artandi, Maja, Barman, Linda, Bennett, Kate, Chakraborty, Saborni, Chang, Iris, Cheung, Peggie, Chinthrajah, Sharon, Dhingra, Shaurya, Do, Evan, Finck, Amanda, Gaano, Andrew, Geßner, Reinhard, Giannini, Heather M., Gonzalez, Joyce, Greib, Sarah, Gündisch, Margrit, Hsu, Alex Ren, Kuo, Alex, Manohar, Monali, Mao, Rong, Neeli, Indira, Neubauer, Andreas, Oniyide, Oluwatosin, Powell, Abigail E., Puri, Rajan, Renz, Harald, Schapiro, Jeffrey, Weidenbacher, Payton A., Wittman, Richard, Ahuja, Neera, Chung, Ho-Ryun, Jagannathan, Prasanna, James, Judith A., Kim, Peter S., Meyer, Nuala J., Nadeau, Kari C., Radic, Marko, Robinson, William H., Singh, Upinder, Wang, Taia T., Wherry, E. John, Skevaki, Chrysanthi, Luning Prak, Eline T., Utz, Paul J.

“…COVID-19 is associated with a wide range of clinical manifestations, including autoimmune features and autoantibody production. Here we develop three protein…”
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Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth by Sangodkar, Jaya, Perl, Abbey, Tohme, Rita, Kiselar, Janna, Kastrinsky, David B, Zaware, Nilesh, Izadmehr, Sudeh, Mazhar, Sahar, Wiredja, Danica D, O'Connor, Caitlin M, Hoon, Divya, Dhawan, Neil S, Schlatzer, Daniela, Yao, Shen, Leonard, Daniel, Borczuk, Alain C, Gokulrangan, Giridharan, Wang, Lifu, Svenson, Elena, Farrington, Caroline C, Yuan, Eric, Avelar, Rita A, Stachnik, Agnes, Smith, Blake, Gidwani, Vickram, Giannini, Heather M, McQuaid, Daniel, McClinch, Kimberly, Wang, Zhizhi, Levine, Alice C, Sears, Rosalie C, Chen, Edward Y, Duan, Qiaonan, Datt, Manish, Haider, Shozeb, Ma'ayan, Avi, DiFeo, Analisa, Sharma, Neelesh, Galsky, Matthew D, Brautigan, David L, Ioannou, Yiannis A, Xu, Wenqing, Chance, Mark R, Ohlmeyer, Michael, Narla, Goutham

“…Targeted cancer therapies, which act on specific cancer-associated molecular targets, are predominantly inhibitors of oncogenic kinases. While these drugs have…”
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ABO Histo-Blood Group and the von Willebrand Factor Axis in Severe COVID-19 by Reilly, John P., Shashaty, Michael G.S., Miano, Todd A., Giannini, Heather M., Jones, Tiffanie K., Ittner, Caroline A.G., Christie, Jason D., Meyer, Nuala J.

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Validating a Proteomic Signature of Severe COVID-19 by Cosgriff, Christopher V, Miano, Todd A, Mathew, Divij, Huang, Alexander C, Giannini, Heather M, Kuri-Cervantes, Leticia, Pampena, M Betina, Ittner, Caroline A G, Weisman, Ariel R, Agyekum, Roseline S, Dunn, Thomas G, Oniyide, Oluwatosin, Turner, Alexandra P, D'Andrea, Kurt, Adamski, Sharon, Greenplate, Allison R, Anderson, Brian J, Harhay, Michael O, Jones, Tiffanie K, Reilly, John P, Mangalmurti, Nilam S, Shashaty, Michael G S, Betts, Michael R, Wherry, E John, Meyer, Nuala J

“…COVID-19 is a heterogenous disease. Biomarker-based approaches may identify patients at risk for severe disease, who may be more likely to benefit from…”
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Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared to adult and pediatric COVID-19 by Vella, Laura A, Giles, Josephine R, Baxter, Amy E, Oldridge, Derek A, Diorio, Caroline, Kuri-Cervantes, Leticia, Alanio, Cécile, Pampena, M Betina, Wu, Jennifer E, Chen, Zeyu, Huang, Yinghui Jane, Anderson, Elizabeth M, Gouma, Sigrid, McNerney, Kevin O, Chase, Julie, Burudpakdee, Chakkapong, Lee, Jessica H, Apostolidis, Sokratis A, Huang, Alexander C, Mathew, Divij, Kuthuru, Oliva, Goodwin, Eileen C, Weirick, Madison E, Bolton, Marcus J, Arevalo, Claudia P, Ramos, Andre, Jasen, C J, Conrey, Peyton E, Sayed, Samir, Giannini, Heather M, D'Andrea, Kurt, Meyer, Nuala J, Behrens, Edward M, Bassiri, Hamid, Hensley, Scott E, Henrickson, Sarah E, Teachey, David T, Betts, Michael R, Wherry, E John

“…Pediatric COVID-19 following SARS-CoV-2 infection is associated with fewer hospitalizations and often milder disease than in adults. A subset of children,…”
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Corrigendum to “Reengineered tricyclic anti-cancer agents” [Bioorg. Med. Chem. 23 (2015) 6528–6534] by Kastrinsky, David B., Sangodkar, Jaya, Zaware, Nilesh, McClinch, Kimberly, Farrington, Caroline C., Giannini, Heather M., Izadmehr, Sudeh, Dhawan, Neil S., Narla, Goutham, Ohlmeyer, Michael

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Signaling Through FcγRIIA and the C5a-C5aR Pathway Mediate Platelet Hyperactivation in COVID-19 by Apostolidis, Sokratis A, Sarkar, Amrita, Giannini, Heather M, Goel, Rishi R, Mathew, Divij, Suzuki, Aae, Baxter, Amy E, Greenplate, Allison R, Alanio, Cécile, Abdel-Hakeem, Mohamed, Oldridge, Derek A, Giles, Josephine R, Wu, Jennifer E, Chen, Zeyu, Huang, Yinghui Jane, Belman, Jonathan, Pattekar, Ajinkya, Manne, Sasikanth, Kuthuru, Oliva, Dougherty, Jeanette, Weiderhold, Brittany, Weisman, Ariel R, Ittner, Caroline A G, Gouma, Sigrid, Dunbar, Debora, Frank, Ian, Huang, Alexander C, Vella, Laura A, Reilly, John P, Hensley, Scott E, Rauova, Lubica, Zhao, Liang, Meyer, Nuala J, Poncz, Mortimer, Abrams, Charles S, Wherry, E John

“…Patients with COVID-19 present with a wide variety of clinical manifestations. Thromboembolic events constitute a significant cause of morbidity and mortality…”
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Genetics of Acute Respiratory Distress Syndrome by Giannini, Heather M., Meyer, Nuala J.

“…Clinical risk factors alone fail to fully explain acute respiratory distress syndrome (ARDS) risk or ARDS death, suggesting that individual risk factors…”
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CD8+ T cells contribute to survival in patients with COVID-19 and hematologic cancer by Bange, Erin M., Han, Nicholas A., Wileyto, Paul, Kim, Justin Y., Gouma, Sigrid, Robinson, James, Greenplate, Allison R., Hwee, Madeline A., Porterfield, Florence, Owoyemi, Olutosin, Naik, Karan, Zheng, Cathy, Galantino, Michael, Weisman, Ariel R., Ittner, Caroline A. G., Kugler, Emily M., Baxter, Amy E., Oniyide, Olutwatosin, Agyekum, Roseline S., Dunn, Thomas G., Jones, Tiffanie K., Giannini, Heather M., Weirick, Madison E., McAllister, Christopher M., Babady, N. Esther, Kumar, Anita, Widman, Adam J., DeWolf, Susan, Boutemine, Sawsan R., Roberts, Charlotte, Budzik, Krista R., Tollett, Susan, Wright, Carla, Perloff, Tara, Sun, Lova, Mathew, Divij, Giles, Josephine R., Oldridge, Derek A., Wu, Jennifer E., Alanio, Cécile, Adamski, Sharon, Garfall, Alfred L., Vella, Laura A., Kerr, Samuel J., Cohen, Justine V., Oyer, Randall A., Massa, Ryan, Maillard, Ivan P., Maxwell, Kara N., Reilly, John P., Maslak, Peter G., Vonderheide, Robert H., Wolchok, Jedd D., Hensley, Scott E., Wherry, E. John, Meyer, Nuala J., DeMichele, Angela M., Vardhana, Santosha A., Mamtani, Ronac, Huang, Alexander C.

“…Patients with cancer have high mortality from coronavirus disease 2019 (COVID-19), and the immune parameters that dictate clinical outcomes remain unknown. In…”
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Genome-Wide Association Study (GWAS) in Critically Ill Sepsis Patients Identifies Single Nucleotide Polymorphisms (SNPs) Associated with AKI by Multiple Definitions: FR-PO094 by Miano, Todd A., Shashaty, Michael G., Reilly, John P., Jones, Tiffanie, Feng, Rui, Turner, Alexandra P., Dunn, Thomas, Ittner, Caroline, Anderson, Brian J., Christie, Jason, Giannini, Heather, Susztak, Katalin, Meyer, Nuala J.

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1192: COVID SEPSIS GENE EXPRESSION SUBPHENOTYPES MANIFEST DIFFERENTIAL PLASMA PROTEIN SIGNATURES by Giannini, Heather, Cosgriff, Christopher, Ronner, Lukas, Sun, Lisa, Turner, Lexi, Dunn, Thomas, Agyekum, Roseline, Ittner, Caroline, Jones, Tiffanie, Miano, Todd, Reilly, John, Shashaty, Michael, Liesenfeld, Oliver, Sweeney, Timothy, Meyer, Nuala

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Prospective Study of Immune Phenotype and Associated Outcomes in Patients with Leukemia and Acute Respiratory Distress Syndrome by Ronner, Lukas, Giannini, Heather M., Miano, Todd A., Ittner, Caroline A.G., Turner, Alexandra P., Dunn, Thomas G., Agyekum, Roseline S., Dasgupta, Anushka, West, Kirsten, Jones, Tiffanie K., Shashaty, Michael G.S., Reilly, John P., Meyer, Nuala J.

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A genome-wide association study of survival in patients with sepsis by Hernandez-Beeftink, Tamara, Guillen-Guio, Beatriz, Lorenzo-Salazar, Jose M, Corrales, Almudena, Suarez-Pajes, Eva, Feng, Rui, Rubio-Rodríguez, Luis A, Paynton, Megan L, Cruz, Raquel, García-Laorden, M Isabel, Prieto-González, Miryam, Rodríguez-Pérez, Aurelio, Carriedo, Demetrio, Blanco, Jesús, Ambrós, Alfonso, González-Higueras, Elena, Espinosa, Elena, Muriel, Arturo, Tamayo, Eduardo, Martin, María M, Lorente, Leonardo, Domínguez, David, de Lorenzo, Abelardo García, Giannini, Heather M, Reilly, John P, Jones, Tiffanie K, Añón, José M, Soro, Marina, Carracedo, Ángel, Wain, Louise V, Meyer, Nuala J, Villar, Jesús, Flores, Carlos

“…Sepsis is a severe systemic inflammatory response to infections that is accompanied by organ dysfunction and has a high mortality rate in adult intensive care…”
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Bronchoalveolar Lavage (BAL) and Pathologic Assessment of Electronic Cigarette or Vaping Product Use-associated Lung Injury (EVALI): The EVALI-BAL Study, A Multicenter Cohort by Harry-Hernandez, Salem, Thiboutot, Jeffrey, Wahidi, Momen M., Giovacchini, Coral X., De Cardenas, Jose, Meldrum, Catherine, Los, Jenna G, Illei, Peter B., Shojaee, Samira, Eissenberg, Thomas, DiBardino, David, Giannini, Heather, Maldonado, Fabien, Roller, Lance, Yarmus, Lonny B, Kapp, Christopher M.

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