Search Results - "Giannini, Alessia"

External quality assessment of HIV-1 DNA quantification assays used in the clinical setting in Italy by Vicenti, Ilaria, Dragoni, Filippo, Giannini, Alessia, Casabianca, Anna, Lombardi, Francesca, Di Sante, Laura, Turriziani, Ombretta, Racca, Sara, Paolucci, Stefania, Lai, Alessia, Bon, Isabella, Abbate, Isabella, Rozera, Gabriella, Belmonti, Simone, Scutari, Rossana, Alteri, Claudia, Saladini, Francesco, Zazzi, Maurizio

“…Total cell-associated HIV-1 DNA is a surrogate marker of the HIV-1 reservoir, however, certified systems for its quantification are not available. The Italian…”
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Comparable In Vitro Activities of Second-Generation HIV-1 Integrase Strand Transfer Inhibitors (INSTIs) on HIV-1 Clinical Isolates with INSTI Resistance Mutations by Saladini, Francesco, Giannini, Alessia, Boccuto, Adele, Dragoni, Filippo, Appendino, Alice, Albanesi, Edoardo, Vicenti, Ilaria, Zazzi, Maurizio

“…Second-generation HIV-1 integrase strand transfer inhibitors (INSTIs) dolutegravir (DTG), bictegravir (BIC), and cabotegravir (CAB) showed a high genetic…”
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Comparative analysis of different cell systems for Zika virus (ZIKV) propagation and evaluation of anti-ZIKV compounds in vitro by Vicenti, Ilaria, Boccuto, Adele, Giannini, Alessia, Dragoni, Filippo, Saladini, Francesco, Zazzi, Maurizio

“…•ZIKV replicates in human, mosquito and monkey cell lines.•Huh7 cells yield maximal production of infectious ZIKV.•Human A549 are effective as the reference…”
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Evaluation of sofosbuvir activity and resistance profile against West Nile virus in vitro by Dragoni, Filippo, Boccuto, Adele, Picarazzi, Francesca, Giannini, Alessia, Giammarino, Federica, Saladini, Francesco, Mori, Mattia, Mastrangelo, Eloise, Zazzi, Maurizio, Vicenti, Ilaria

“…Sofosbuvir, a licensed nucleotide analog targeting hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp), has been recently evaluated as a broad…”
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In vitro susceptibility of HIV-1 CRF02_AG to temsavir, the active compound of the attachment inhibitor fostemsavir by Saladini, Francesco, Giannini, Alessia, Giammarino, Federica, Boccuto, Adele, Dragoni, Filippo, Vicenti, Ilaria, Zazzi, Maurizio

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Agreement between an in‐house replication competent and a reference replication defective recombinant virus assay for measuring phenotypic resistance to HIV‐1 protease, reverse transcriptase, and integrase inhibitors by Saladini, Francesco, Giannini, Alessia, Boccuto, Adele, Vicenti, Ilaria, Zazzi, Maurizio

“…Background Although clinical management of drug resistance is routinely based on genotypic methods, phenotypic assays remain necessary for the characterization…”
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The HIV-1 reverse transcriptase E138A natural polymorphism decreases the genetic barrier to resistance to etravirine in vitro by Giannini, Alessia, Vicenti, Ilaria, Materazzi, Angelo, Boccuto, Adele, Dragoni, Filippo, Zazzi, Maurizio, Saladini, Francesco

“…Abstract Objectives The HIV-1 reverse transcriptase (RT) natural polymorphism E138A is included among the mutations with a minor impact on response to…”
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In vitro cross-resistance to doravirine in a panel of HIV-1 clones harbouring multiple NNRTI resistance mutations by Saladini, Francesco, Giammarino, Federica, Hosseini, Behnaz A, Giannini, Alessia, Boccuto, Adele, Dragoni, Filippo, Vicenti, Ilaria, Shafer, Robert W, Zazzi, Maurizio

“…Doravirine is a recently licensed HIV-1 NNRTI with improved efficacy, pharmacokinetics and safety profile compared with efavirenz and limited cross-resistance…”
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The HIV-1 integrase E157Q polymorphism per se does not alter susceptibility to raltegravir and dolutegravir in vitro by Saladini, Francesco, Giannini, Alessia, Boccuto, Adele, Tiezzi, Diletta, Vicenti, Ilaria, Zazzi, Maurizio

“…The HIV-1 integrase E157Q natural polymorphism has been reported to cause one case of raltegravir (RAL) and dolutegravir (DTG) failure. We constructed six…”
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DDX3X inhibitors, an effective way to overcome HIV-1 resistance targeting host proteins by Brai, Annalaura, Riva, Valentina, Saladini, Francesco, Zamperini, Claudio, Trivisani, Claudia Immacolata, Garbelli, Anna, Pennisi, Carla, Giannini, Alessia, Boccuto, Adele, Bugli, Francesca, Martini, Maurizio, Sanguinetti, Maurizio, Zazzi, Maurizio, Dreassi, Elena, Botta, Maurizio, Maga, Giovanni

“…The huge resources that had gone into Human Immunodeficiency virus (HIV) research led to the development of potent antivirals able to suppress viral load in…”
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Performance of Geno2Pheno[coreceptor] to infer coreceptor use in human immunodeficiency virus type 1 (HIV-1) subtype A by Vicenti, Ilaria, Lai, Alessia, Giannini, Alessia, Boccuto, Adele, Dragoni, Filippo, Saladini, Francesco, Zazzi, Maurizio

“…•Assessment of HIV-1 coreceptor usage with Geno2Pheno[coreceptor] (G2P[c]) algorithm.•Performance of G2P[c] for prediction of tropism with subtype A/CRF02_AG…”
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In vitro susceptibility to fostemsavir is not affected by long-term exposure to antiviral therapy in MDR HIV-1-infected patients by Saladini, Francesco, Giannini, Alessia, Giammarino, Federica, Maggiolo, Franco, Vichi, Francesca, Corbelli, Giulio M, Galli, Andrea, Bigoloni, Alba, Poli, Andrea, Santoro, Maria M, Zazzi, Maurizio, Castagna, Antonella

“…Abstract Objectives Fostemsavir is the prodrug of the HIV-1 attachment inhibitor temsavir and is currently under clinical assessment in heavily…”
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Development of an internally controlled quantitative PCR to measure total cell-associated HIV-1 DNA in blood by Vicenti, Ilaria, Meini, Genny, Saladini, Francesco, Giannini, Alessia, Boccuto, Adele, Schiaroli, Elisabetta, Zazzi, Maurizio

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Maraviroc as a potential HIV-1 latency-reversing agent in cell line models and ex vivo CD4 T cells by Vicenti, Ilaria, Dragoni, Filippo, Monti, Martina, Trombetta, Claudia Maria, Giannini, Alessia, Boccuto, Adele, Saladini, Francesco, Rossetti, Barbara, De Luca, Andrea, Ciabattini, Annalisa, Pastore, Gabiria, Medaglini, Donata, Orofino, Giancarlo, Montomoli, Emanuele, Zazzi, Maurizio

“…Recent studies have suggested that the CCR5 antagonist maraviroc (MVC) may exert an HIV-1 latency reversal effect. This study aimed at defining MVC-mediated…”
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Identification of novel 2-benzoxazolinone derivatives with specific inhibitory activity against the HIV-1 nucleocapsid protein by Gamba, Elia, Mori, Mattia, Kovalenko, Lesia, Giannini, Alessia, Sosic, Alice, Saladini, Francesco, Fabris, Dan, Mély, Yves, Gatto, Barbara, Botta, Maurizio

“…In this report, we present a new benzoxazole derivative endowed with inhibitory activity against the HIV-1 nucleocapsid protein (NC). NC is a 55-residue basic…”
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Multicenter evaluation of a topical hyaluronic acid serum by Robinson, Deanne Mraz, Vega, Janelle, Palm, Melanie D., Bell, Michaela, Widgerow, Alan D., Giannini, Alessia

“…Background A new hyaluronic acid (HA) formulation was developed based on high molecular weight (MW) compounds used on the surface of the skin while using…”
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Synthesis and Evaluation of Bifunctional Aminothiazoles as Antiretrovirals Targeting the HIV‑1 Nucleocapsid Protein by Mori, Mattia, Dasso Lang, Maria Chiara, Saladini, Francesco, Palombi, Nastasja, Kovalenko, Lesia, De Forni, Davide, Poddesu, Barbara, Friggeri, Laura, Giannini, Alessia, Malancona, Savina, Summa, Vincenzo, Zazzi, Maurizio, Mely, Yves, Botta, Maurizio

“…Small molecule inhibitors of the HIV-1 nucleocapsid protein (NC) are considered as promising agents in the treatment of HIV/AIDS. In an effort to exploit the…”
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Structure-Based Identification of HIV‑1 Nucleocapsid Protein Inhibitors Active against Wild-Type and Drug-Resistant HIV‑1 Strains by Mori, Mattia, Kovalenko, Lesia, Malancona, Savina, Saladini, Francesco, De Forni, Davide, Pires, Manuel, Humbert, Nicolas, Real, Eleonore, Botzanowski, Thomas, Cianférani, Sarah, Giannini, Alessia, Dasso Lang, Maria Chiara, Cugia, Giulia, Poddesu, Barbara, Lori, Franco, Zazzi, Maurizio, Harper, Steven, Summa, Vincenzo, Mely, Yves, Botta, Maurizio

“…HIV/AIDS is still one of the leading causes of death worldwide. Current drugs that target the canonical steps of the HIV-1 life cycle are efficient in blocking…”
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5,6-Dihydroxypyrimidine Scaffold to Target HIV‑1 Nucleocapsid Protein by Malancona, Savina, Mori, Mattia, Fezzardi, Paola, Santoriello, Marisabella, Basta, Andreina, Nibbio, Martina, Kovalenko, Lesia, Speziale, Roberto, Battista, Maria Rosaria, Cellucci, Antonella, Gennari, Nadia, Monteagudo, Edith, Di Marco, Annalise, Giannini, Alessia, Sharma, Rajhans, Pires, Manuel, Real, Eleonore, Zazzi, Maurizio, Dasso Lang, Maria Chiara, De Forni, Davide, Saladini, Francesco, Mely, Yves, Summa, Vincenzo, Harper, Steven, Botta, Maurizio

“…The HIV-1 nucleocapsid (NC) protein is a small basic DNA and RNA binding protein that is absolutely necessary for viral replication and thus represents a…”
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(Thia)calixarenephosphonic Acids as Potent Inhibitors of the Nucleic Acid Chaperone Activity of the HIV‑1 Nucleocapsid Protein with a New Binding Mode and Multitarget Antiviral Activity by Humbert, Nicolas, Kovalenko, Lesia, Saladini, Francesco, Giannini, Alessia, Pires, Manuel, Botzanowski, Thomas, Cherenok, Sergiy, Boudier, Christian, Sharma, Kamal K, Real, Eleonore, Zaporozhets, Olga A, Cianférani, Sarah, Seguin-Devaux, Carole, Poggialini, Federica, Botta, Maurizio, Zazzi, Maurizio, Kalchenko, Vitaly I, Mori, Mattia, Mély, Yves

“…The nucleocapsid protein (NC) is a highly conserved protein that plays key roles in HIV-1 replication through its nucleic acid chaperone properties mediated by…”
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