Search Results - "Gianni, M"
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ACE2 and TMPRSS2 are expressed on the human ocular surface, suggesting susceptibility to SARS-CoV-2 infection
Published in The ocular surface (01-10-2020)“…Conjunctival signs and symptoms are observed in a subset of patients with COVID-19, and SARS-CoV-2 has been detected in tears, raising concerns regarding the…”
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Evolutionary pathways to SARS-CoV-2 resistance are opened and closed by epistasis acting on ACE2
Published in PLoS biology (21-12-2021)“…Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infects a broader range of mammalian species than previously predicted, binding a diversity of…”
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Adaptation of the master antioxidant response connects metabolism, lifespan and feather development pathways in birds
Published in Nature communications (18-05-2020)“…Birds (Aves) display high metabolic rates and oxygen consumption relative to mammals, increasing reactive oxygen species (ROS) formation. Although excess ROS…”
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Catastrophic slab loss in southwestern Pangea preserved in the mantle and igneous record
Published in Nature communications (04-02-2022)“…The Choiyoi Magmatic Province represents a major episode of silicic magmatism in southwestern Pangea in the mid-Permian-Triassic, the origin of which remains…”
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Spatial and Temporal Regulation of Receptor Tyrosine Kinase Activation and Intracellular Signal Transduction
Published in Annual review of biochemistry (02-06-2016)“…Epidermal growth factor (EGF) and insulin receptor tyrosine kinases (RTKs) exemplify how receptor location is coupled to signal transduction. Extracellular…”
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Pervasive mutations of JAK-STAT pathway genes in classical Hodgkin lymphoma
Published in Blood (31-05-2018)“…Dissecting the pathogenesis of classical Hodgkin lymphoma (cHL), a common cancer in young adults, remains challenging because of the rarity of tumor cells in…”
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Acetylenic tricyclic bis-(cyano enone) interacts with Cys 374 of actin, a residue necessary for stress fiber formation and cell migration
Published in Biochimica et biophysica acta. Molecular cell research (01-02-2024)“…The migratory and invasive potential of tumour cells relies on the actin cytoskeleton. We previously demonstrated that the tricyclic compound, TBE-31, inhibits…”
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Prolonged proteasome inhibition antagonizes TGFβ1-dependent signalling by promoting the lysosomal-targeting of TGFβ receptors
Published in Cellular signalling (01-10-2022)“…Impairing autophagy disrupts transforming growth factor beta 1 (TGFβ1) signalling and epithelial-mesenchymal transition (EMT) in non-small cell lung cancer…”
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GPR54 (KISS1R) transactivates EGFR to promote breast cancer cell invasiveness
Published in PloS one (28-06-2011)“…Kisspeptins (Kp), peptide products of the Kisspeptin-1 (KISS1) gene are endogenous ligands for a G protein-coupled receptor 54 (GPR54). Previous findings have…”
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Author Correction: Catastrophic slab loss in southwestern Pangea preserved in the mantle and igneous record
Published in Nature communications (19-04-2022)Get full text
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Atypical Protein Kinase C Phosphorylates Par6 and Facilitates Transforming Growth Factor β-Induced Epithelial-to-Mesenchymal Transition
Published in Molecular and Cellular Biology (01-03-2013)“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Brentuximab vedotin as consolidation therapy after autologous stem-cell transplantation in patients with Hodgkin's lymphoma at risk of relapse or progression (AETHERA): a randomised, double-blind, placebo-controlled, phase 3 trial
Published in The Lancet (British edition) (09-05-2015)“…Summary Background High-dose therapy followed by autologous stem-cell transplantation is standard of care for patients with relapsed or primary refractory…”
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Transforming growth factor-β in tumour development
Published in Frontiers in molecular biosciences (04-10-2022)“…Transforming growth factor-β (TGFβ) is a ubiquitous cytokine essential for embryonic development and postnatal tissue homeostasis. TGFβ signalling regulates…”
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Network-guided modeling allows tumor-type independent prediction of sensitivity to all-trans-retinoic acid
Published in Annals of oncology (01-03-2017)“…All-trans-retinoic acid (ATRA) is a differentiating agent used in the treatment of acute-promyelocytic-leukemia (APL) and it is under-exploited in other…”
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Ghost-arc geochemical anomaly at a spreading ridge caused by supersized flat subduction
Published in Nature communications (12-04-2023)“…The Southern Atlantic-Southwest Indian ridges (SASWIR) host mid-ocean ridge basalts with a residual subduction-related geochemical fingerprint (i.e., a…”
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Biodiversity loss from deep-sea mining
Published in Nature geoscience (01-07-2017)Get full text
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Scientific rationale and international obligations for protection of active hydrothermal vent ecosystems from deep-sea mining
Published in Marine policy (01-04-2018)“…There is increasing interest in mining minerals on the seabed, including seafloor massive sulfide deposits that form at hydrothermal vents. The International…”
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Functional trade-offs and environmental variation shaped ancient trajectories in the evolution of dim-light vision
Published in eLife (26-10-2018)“…Trade-offs between protein stability and activity can restrict access to evolutionary trajectories, but widespread epistasis may facilitate indirect routes to…”
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Decorin Is a Novel VEGFR-2-Binding Antagonist for the Human Extravillous Trophoblast
Published in Molecular endocrinology (Baltimore, Md.) (01-08-2011)“…Extravillous trophoblasts (EVT) of the human placenta invade the uterine decidua and its arteries to ensure successful placentation. We previously identified…”
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Prevalence and Clinical History of Incidental, Asymptomatic Pulmonary Embolism: A Meta-Analysis
Published in Thrombosis research (01-06-2010)“…Abstract Context Recently, there has been an increasing number of reports of incidental pulmonary embolism (PE) in patients undergoing chest computer…”
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