Outcomes of single- versus multi-port video-assisted thoracoscopic surgery: Data from a multicenter randomized controlled trial of video-assisted thoracoscopic surgery versus thoracotomy for lung cancerCentral MessagePerspective

Objectives: Surgery through a single port may be less painful because access is supplied by 1 intercostal nerve or more painful because multiple instruments are used in 1 port. We analyzed data collected from the video-assisted thoracoscopic surgery group of a randomized controlled trial to compare...

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Bibliographic Details
Published in:	JTCVS open Vol. 19; pp. 296 - 308
Main Authors:	Eric Lim, MD, Rosie A. Harris, MSc, Tim Batchelor, Bsc (Hons), MBChB, FRCS, Gianluca Casali, MEDGB, Rakesh Krishnadas, MD, Sofina Begum, MD, Simon Jordan, MD, Joel Dunning, MD, Ian Paul, MD, Michael Shackcloth, MD, Sarah Feeney, RN, Vladimir Anikin, MD, Niall Mcgonigle, MD, Hazem Fallouh, MD, Luis Hernandez, MD, Franscesco Di Chiara, MD, Dionisios Stavroulias, MD, Mahmoud Loubani, MD, Syed Qadri, MD, Vipin Zamvar, MD, Lucy Marshall, RN, Surinder Kaur, BSc, Chris A. Rogers, PhD
Format:	Journal Article
Language:	English
Published:	Elsevier 01-06-2024
Subjects:	multi-port VATS postoperative pain single-port VATS
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Summary:	Objectives: Surgery through a single port may be less painful because access is supplied by 1 intercostal nerve or more painful because multiple instruments are used in 1 port. We analyzed data collected from the video-assisted thoracoscopic surgery group of a randomized controlled trial to compare differences in pain up to 1 year. Methods: Groups were compared in a prespecified exploratory analysis using direct (regression) and indirect comparison (difference with respect to thoracotomy). In-hospital visual analogue scale pain scores were used, and analgesic ratios were calculated. After discharge, pain was evaluated using European Organization for Research and Treatment of Cancer Quality of Life Questionnaires-Core 30 scores up to 1 year. Results: From July 2015 to February 2019, we randomized 503 participants. After excluding 50 participants who did not receive lobectomy, surgery was performed using a single port in 42 participants (predominately by a single surgeon), multiple ports in 166 participants, and thoracotomy in 245 participants. No differences were observed in-hospital between single- and multiple-port video-assisted thoracoscopic surgery when modeled using a direct comparison, mean difference of −0.24 (95% CI, −1.06 to 0.58) or indirect comparison, mean difference of −0.33 (−1.16 to 0.51). Mean analgesic ratio (single/multiple port) was 0.75 (0.64 to 0.87) for direct comparison and 0.90 (0.64 to 1.25) for indirect comparison. After discharge, pain for single-port video-assisted thoracoscopic surgery was lower than for multiple-port video-assisted thoracoscopic surgery (first 3 months), and corresponding physical function was higher up to 12 months. Conclusions: There were no consistent differences for in-hospital pain when lobectomy was undertaken using 1 or multiple ports. However, better pain scores and physical function were observed for single-port surgery after discharge.
ISSN:	2666-2736