Search Results - "Giang Nguyen"
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The role of blockchain technology-based social crowdfunding in advancing social value creation
Published in Technological forecasting & social change (01-09-2021)“…•Application of blockchain technology in crowdfunding platforms is investigated.•Four themes emerge: reliability, transparency, trustworthiness, and social…”
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Protein–Small Molecule Interactions in Native Mass Spectrometry
Published in Chemical reviews (27-04-2022)“…Small molecule drug discovery has been propelled by the continual development of novel scientific methodologies to occasion therapeutic advances. Although…”
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Butelase 1 is an Asx-specific ligase enabling peptide macrocyclization and synthesis
Published in Nature chemical biology (01-09-2014)“…Peptide macrocycles are attracting increasing attention as tools for research and as potential therapeutics. The highly efficient butelase 1—homologous to…”
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Engineering a Catalytically Efficient Recombinant Protein Ligase
Published in Journal of the American Chemical Society (19-04-2017)“…Breaking and forming peptidyl bonds are fundamental biochemical reactions in protein chemistry. Unlike proteases that are abundantly available, fast-acting…”
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SDN/NFV-Based Mobile Packet Core Network Architectures: A Survey
Published in IEEE Communications surveys and tutorials (01-01-2017)“…The emergence of two new technologies, namely, software defined networking (SDN) and network function virtualization (NFV), have radically changed the…”
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Smoothed particle hydrodynamics (SPH) and its applications in geomechanics: From solid fracture to granular behaviour and multiphase flows in porous media
Published in Computers and geotechnics (01-10-2021)“…We present the fundamental concepts of SPH with particular emphasis on its state-of-the-art applications in geomechanics and geotechnical engineering. In the…”
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Perfluoroalkyl Substances of Significant Environmental Concern Can Strongly Inhibit Human Carbonic Anhydrase Isozymes
Published in Analytical chemistry (Washington) (17-03-2020)“…Perfluoroalkyl substances (PFASs) persist and are ubiquitous in the environment. The origins of PFAS toxicity and how they specifically affect the functions of…”
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Total Synthesis of Circular Bacteriocins by Butelase 1
Published in Journal of the American Chemical Society (08-06-2016)“…Circular bacteriocins, ranging from 35 to 70 amino acids, are the largest cyclic peptides produced by lactic acid bacteria to suppress growth of other…”
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Neutrophils to the ROScue: Mechanisms of NADPH Oxidase Activation and Bacterial Resistance
Published in Frontiers in cellular and infection microbiology (25-08-2017)“…Reactive oxygen species (ROS) generated by NADPH oxidase play an important role in antimicrobial host defense and inflammation. Their deficiency in humans…”
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10
Butelase-mediated cyclization and ligation of peptides and proteins
Published in Nature protocols (01-10-2016)“…This protocol from Nguyen et al . describes the use of the plant cyclase butelase 1 for the efficient cyclization and ligation of peptides and proteins. After…”
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11
Graph Convolutional Networks for Drug Response Prediction
Published in IEEE/ACM transactions on computational biology and bioinformatics (01-01-2022)“…Background : Drug response prediction is an important problem in computational personalized medicine. Many machine-learning-based methods, especially deep…”
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A coupled fluid-solid SPH approach to modelling flow through deformable porous media
Published in International journal of solids and structures (15-10-2017)“…•A new coupled fluid-solid approach to modelling flow through deformable porous media is presented.•Both solid and fluid phases are evolved in two different…”
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Mechanism for the Binding of Netropsin to Hairpin DNA Revealed Using Nanoscale Ion Emitters in Native Mass Spectrometry
Published in Analytical chemistry (Washington) (07-01-2020)“…Netropsin is one of the first ligands to be discovered that selectively binds to the minor groove of DNA and is actively used as a scaffold for developing…”
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Multiplexed Screening of Thousands of Natural Products for Protein–Ligand Binding in Native Mass Spectrometry
Published in Journal of the American Chemical Society (22-12-2021)“…The structural diversity of natural products offers unique opportunities for drug discovery, but challenges associated with their isolation and screening can…”
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Enzymatic Engineering of Live Bacterial Cell Surfaces Using Butelase 1
Published in Angewandte Chemie International Edition (26-06-2017)“…Butelase‐mediated ligation (BML) can be used to modify live bacterial cell surfaces with diverse cargo molecules. Surface‐displayed butelase recognition motif…”
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Chemical Probing of the Human Sirtuin 5 Active Site Reveals Its Substrate Acyl Specificity and Peptide-Based Inhibitors
Published in Angewandte Chemie International Edition (26-09-2014)“…Sirtuins are NAD+‐dependent deacetylases acting as sensors in metabolic pathways and stress response. In mammals there are seven isoforms. The mitochondrial…”
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17
Liquidity and volatility in the U.S. Treasury market
Published in Journal of econometrics (01-08-2020)“…We model the joint dynamics of intraday liquidity, volume, and volatility in the U.S. Treasury market, especially through the 2007–09 financial crisis and…”
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Butelase-Mediated Macrocyclization of d-Amino-Acid-Containing Peptides
Published in Angewandte Chemie International Edition (04-10-2016)“…Macrocyclic compounds have received increasing attention in recent years. With their large surface area, they hold promise for inhibiting protein–protein…”
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Low-noise GaAs quantum dots for quantum photonics
Published in Nature communications (21-09-2020)“…Quantum dots are both excellent single-photon sources and hosts for single spins. This combination enables the deterministic generation of…”
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Site-Specific N-Terminal Labeling of Peptides and Proteins using Butelase 1 and Thiodepsipeptide
Published in Angewandte Chemie International Edition (21-12-2015)“…An efficient ligase with exquisite site‐specificity is highly desirable for protein modification. Recently, we discovered the fastest known ligase called…”
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