Search Results - "Giampaolo, Tortora"

Maintenance Olaparib for Germline BRCA-Mutated Metastatic Pancreatic Cancer by Golan, Talia, Hammel, Pascal, Reni, Michele, Van Cutsem, Eric, Macarulla, Teresa, Hall, Michael J, Park, Joon-Oh, Hochhauser, Daniel, Arnold, Dirk, Oh, Do-Youn, Reinacher-Schick, Anke, Tortora, Giampaolo, Algül, Hana, O’Reilly, Eileen M, McGuinness, David, Cui, Karen Y, Schlienger, Katia, Locker, Gershon Y, Kindler, Hedy L

“…Approximately 7% of pancreatic cancers occur in patients with a germline mutation in BRCA1 or BRCA2 , an alteration that compromises DNA repair. In a…”
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Gut microbiome, big data and machine learning to promote precision medicine for cancer by Cammarota, Giovanni, Ianiro, Gianluca, Ahern, Anna, Carbone, Carmine, Temko, Andriy, Claesson, Marcus J., Gasbarrini, Antonio, Tortora, Giampaolo

“…The gut microbiome has been implicated in cancer in several ways, as specific microbial signatures are known to promote cancer development and influence…”
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Faecal microbiota transplantation for the treatment of diarrhoea induced by tyrosine-kinase inhibitors in patients with metastatic renal cell carcinoma by Ianiro, Gianluca, Rossi, Ernesto, Thomas, Andrew M., Schinzari, Giovanni, Masucci, Luca, Quaranta, Gianluca, Settanni, Carlo Romano, Lopetuso, Loris Riccardo, Armanini, Federica, Blanco-Miguez, Aitor, Asnicar, Francesco, Consolandi, Clarissa, Iacovelli, Roberto, Sanguinetti, Maurizio, Tortora, Giampaolo, Gasbarrini, Antonio, Segata, Nicola, Cammarota, Giovanni

“…Diarrhoea is one of the most burdensome and common adverse events of chemotherapeutics, and has no standardised therapy to date. Increasing evidence suggests…”
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Differential Activity of Nivolumab, Pembrolizumab and MPDL3280A according to the Tumor Expression of Programmed Death-Ligand-1 (PD-L1): Sensitivity Analysis of Trials in Melanoma, Lung and Genitourinary Cancers by Carbognin, Luisa, Pilotto, Sara, Milella, Michele, Vaccaro, Vanja, Brunelli, Matteo, Caliò, Anna, Cuppone, Federica, Sperduti, Isabella, Giannarelli, Diana, Chilosi, Marco, Bronte, Vincenzo, Scarpa, Aldo, Bria, Emilio, Tortora, Giampaolo

“…The potential predictive role of programmed death-ligand-1 (PD-L1) expression on tumor cells in the context of solid tumor treated with checkpoint inhibitors…”
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Angiopoietin-Like Proteins in Angiogenesis, Inflammation and Cancer by Carbone, Carmine, Piro, Geny, Merz, Valeria, Simionato, Francesca, Santoro, Raffaela, Zecchetto, Camilla, Tortora, Giampaolo, Melisi, Davide

“…Altered expression of secreted factors by tumor cells or cells of the tumor microenvironment is a key event in cancer development and progression. In the last…”
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Predictive value of NLR, TILs (CD4+/CD8+) and PD-L1 expression for prognosis and response to preoperative chemotherapy in gastric cancer by Zurlo, Ina Valeria, Schino, Mattia, Strippoli, Antonia, Calegari, Maria Alessandra, Cocomazzi, Alessandra, Cassano, Alessandra, Pozzo, Carmelo, Di Salvatore, Mariantonietta, Ricci, Riccardo, Barone, Carlo, Bria, Emilio, Tortora, Giampaolo, Larocca, Luigi Maria, Basso, Michele, Martini, Maurizio

“…The combination of perioperative chemotherapy plus complete surgical resection is currently accounted as the first-choice strategy in patients with locally…”
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Mutational status of plasma exosomal KRAS predicts outcome in patients with metastatic colorectal cancer by Lucchetti, Donatella, Zurlo, Ina Valeria, Colella, Filomena, Ricciardi-Tenore, Claudio, Di Salvatore, Mariantonietta, Tortora, Giampaolo, De Maria, Ruggero, Giuliante, Felice, Cassano, Alessandra, Basso, Michele, Crucitti, Antonio, Laurenzana, Ilaria, Artemi, Giulia, Sgambato, Alessandro

“…Liquid biopsy has become a useful alternative in metastatic colorectal cancer (mCRC) patients when tissue biopsy of metastatic sites is not feasible. In this…”
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Unmasking the impact of Rictor in cancer: novel insights of mTORC2 complex by Gkountakos, Anastasios, Pilotto, Sara, Mafficini, Andrea, Vicentini, Caterina, Simbolo, Michele, Milella, Michele, Tortora, Giampaolo, Scarpa, Aldo, Bria, Emilio, Corbo, Vincenzo

“…In this review, we highlighted and discussed current knowledge about the role of Rictor in development and progression of cancer focusing on the major…”
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KRAS-Dependency in Pancreatic Ductal Adenocarcinoma: Mechanisms of Escaping in Resistance to KRAS Inhibitors and Perspectives of Therapy by Gurreri, Enrico, Genovese, Giannicola, Perelli, Luigi, Agostini, Antonio, Piro, Geny, Carbone, Carmine, Tortora, Giampaolo

“…Pancreatic ductal adenocarcinoma (PDAC) is still one of the deadliest cancers in oncology because of its increasing incidence and poor survival rate. More than…”
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A Novel Approach in the Treatment of Cancer: Targeting the Epidermal Growth Factor Receptor by CIARDIELLO, Fortunato, TORTORA, Giampaolo

“…The epidermal growth factor receptor (EGFR) autocrine pathway contributes to a number of processes important to cancer development and progression, including…”
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Molecular alterations in basal cell carcinoma subtypes by Di Nardo, Lucia, Pellegrini, Cristina, Di Stefani, Alessandro, Ricci, Francesco, Fossati, Barbara, Del Regno, Laura, Carbone, Carmine, Piro, Geny, Corbo, Vincenzo, Delfino, Pietro, De Summa, Simona, Maturo, Maria Giovanna, Rocco, Tea, Tortora, Giampaolo, Fargnoli, Maria Concetta, Peris, Ketty

“…A number of genes have been implicated in the pathogenesis of BCC in addition to the Hedgehog pathway, which is known to drive the initiation of this tumour…”
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Post nephrectomy management of localized renal cell carcinoma. From risk stratification to therapeutic evidence in an evolving clinical scenario by Ciccarese, Chiara, Strusi, Alessandro, Arduini, Daniela, Russo, Pierluigi, Palermo, Giuseppe, Foschi, Nazario, Racioppi, Marco, Tortora, Giampaolo, Iacovelli, Roberto

“…•About 35% of localized RCC patients recur after nephrectomy.•A unique and universally accepted risk factor model is still missing.•VEGFR-TKIs failed in…”
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PTEN in Colorectal Cancer: Shedding Light on Its Role as Predictor and Target by Salvatore, Lisa, Calegari, Maria Alessandra, Loupakis, Fotios, Fassan, Matteo, Di Stefano, Brunella, Bensi, Maria, Bria, Emilio, Tortora, Giampaolo

“…Molecular assessment of colorectal cancer (CRC) is receiving growing attention, beyond RAS and BRAF, because of its influence on prognosis and prediction in…”
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Sex-Based Dimorphism of Anticancer Immune Response and Molecular Mechanisms of Immune Evasion by Conforti, Fabio, Pala, Laura, Pagan, Eleonora, Bagnardi, Vincenzo, De Pas, Tommaso, Queirolo, Paola, Pennacchioli, Elisabetta, Catania, Chiara, Cocorocchio, Emilia, Ferrucci, Pier Francesco, Saponara, Maristella, Orsolini, Gianmarco, Zagami, Paola, Nicoló, Eleonora, De Marinis, Filippo, Tortora, Giampaolo, Bria, Emilio, Minucci, Saverio, Joffe, Hadine, Veronesi, Paolo, Wargo, Jennifer, Rosenthal, Rachel, Swanton, Charles, Mantovani, Alberto, Gelber, Richard D, Viale, Giuseppe, Goldhirsch, Aron, Giaccone, Giuseppe

“…We previously demonstrated that sex influences response to immune checkpoint inhibitors. In this article, we investigate sex-based differences in the molecular…”
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Prostate Cancer Heterogeneity: Discovering Novel Molecular Targets for Therapy by Ciccarese, Chiara, Massari, Francesco, Iacovelli, Roberto, Fiorentino, Michelangelo, Montironi, Rodolfo, Di Nunno, Vincenzo, Giunchi, Francesca, Brunelli, Matteo, Tortora, Giampaolo

“…Highlights • Prostate cancer (PCa) shows a broad spectrum of biological and clinical behavior, which represents the epiphenomenon of an extreme genetic…”
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Homeobox B9 Mediates Resistance to Anti-VEGF Therapy in Colorectal Cancer Patients by Carbone, Carmine, Piro, Geny, Simionato, Francesca, Ligorio, Francesca, Cremolini, Chiara, Loupakis, Fotios, Alì, Greta, Rossini, Daniele, Merz, Valeria, Santoro, Raffaela, Zecchetto, Camilla, Zanotto, Marco, Di Nicolantonio, Federica, Bardelli, Alberto, Fontanini, Gabriella, Tortora, Giampaolo, Melisi, Davide

“…The identification of predictive biomarkers for antiangiogenic therapies remains an unmeet need. We hypothesized that the transcription factor Homeobox B9…”
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Can histogram analysis of MR images predict aggressiveness in pancreatic neuroendocrine tumors? by De Robertis, Riccardo, Maris, Bogdan, Cardobi, Nicolò, Tinazzi Martini, Paolo, Gobbo, Stefano, Capelli, Paola, Ortolani, Silvia, Cingarlini, Sara, Paiella, Salvatore, Landoni, Luca, Butturini, Giovanni, Regi, Paolo, Scarpa, Aldo, Tortora, Giampaolo, D’Onofrio, Mirko

“…Objectives To evaluate MRI derived whole-tumour histogram analysis parameters in predicting pancreatic neuroendocrine neoplasm (panNEN) grade and…”
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The Interplay between Immunity and Microbiota at Intestinal Immunological Niche: The Case of Cancer by Cianci, Rossella, Franza, Laura, Schinzari, Giovanni, Rossi, Ernesto, Ianiro, Gianluca, Tortora, Giampaolo, Gasbarrini, Antonio, Gambassi, Giovanni, Cammarota, Giovanni

“…The gut microbiota is central to the pathogenesis of several inflammatory and autoimmune diseases. While multiple mechanisms are involved, the immune system…”
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Emerging concepts on drug resistance in bladder cancer: Implications for future strategies by Massari, Francesco, Santoni, Matteo, Ciccarese, Chiara, Brunelli, Matteo, Conti, Alessandro, Santini, Daniele, Montironi, Rodolfo, Cascinu, Stefano, Tortora, Giampaolo

“…Highlights • We examine the recent findings on the mechanisms of drug resistance in bladder cancer. • We report the methods employed in the assessment of these…”
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Pneumonitis from immune checkpoint inhibitors and COVID-19: current concern in cancer treatment by Rossi, Ernesto, Schinzari, Giovanni, Tortora, Giampaolo

“…Pneumonitis is a rare but serious adverse event caused by cancer immunotherapy. The diagnosis between COVID-19-induced pneumonia and immunotherapy-induced…”
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