Search Results - "Giacomini, Arianna"

Fibroblast growth factors (FGFs) in cancer: FGF traps as a new therapeutic approach by Presta, Marco, Chiodelli, Paola, Giacomini, Arianna, Rusnati, Marco, Ronca, Roberto

“…Originally characterized as angiogenic factors, fibroblast growth factors (FGFs) are pleiotropic factors that exert autocrine and paracrine functions on tumor…”
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The potential of fibroblast growth factor/fibroblast growth factor receptor signaling as a therapeutic target in tumor angiogenesis by Ronca, Roberto, Giacomini, Arianna, Rusnati, Marco, Presta, Marco

“…Fibroblast growth factors (FGFs) are endowed with a potent pro-angiogenic activity. Activation of the FGF/FGF receptor (FGFR) system occurs in a variety of…”
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Future applications of FGF/FGFR inhibitors in cancer by Ghedini, Gaia Cristina, Ronca, Roberto, Presta, Marco, Giacomini, Arianna

“…Introduction: Deregulation of the fibroblast growth factor (FGF)/FGF receptor (FGFR) network occurs frequently in tumors due to gene amplification, activating…”
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Long-Pentraxin 3 Derivative as a Small-Molecule FGF Trap for Cancer Therapy by Ronca, Roberto, Giacomini, Arianna, Di Salle, Emanuela, Coltrini, Daniela, Pagano, Katiuscia, Ragona, Laura, Matarazzo, Sara, Rezzola, Sara, Maiolo, Daniele, Torella, Rubben, Moroni, Elisabetta, Mazzieri, Roberta, Escobar, Giulia, Mor, Marco, Colombo, Giorgio, Presta, Marco

“…The fibroblast growth factor (FGF)/FGF receptor (FGFR) system plays a crucial role in cancer by affecting tumor growth, angiogenesis, drug resistance, and…”
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Quantification of 3D Brain Microangioarchitectures in an Animal Model of Krabbe Disease by Righi, Marco, Belleri, Mirella, Presta, Marco, Giacomini, Arianna

“…We performed a three-dimensional (3D) analysis of the microvascular network of the cerebral cortex of twitcher mice (an authentic model of Krabbe disease)…”
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Cannabidiol alters mitochondrial bioenergetics via VDAC1 and triggers cell death in hormone-refractory prostate cancer by Mahmoud, Ali Mokhtar, Kostrzewa, Magdalena, Marolda, Viviana, Cerasuolo, Marianna, Maccarinelli, Federica, Coltrini, Daniela, Rezzola, Sara, Giacomini, Arianna, Mollica, Maria Pina, Motta, Andrea, Paris, Debora, Zorzano, Antonio, Di Marzo, Vincenzo, Ronca, Roberto, Ligresti, Alessia

“…In spite of the huge advancements in both diagnosis and interventions, hormone refractory prostate cancer (HRPC) remains a major hurdle in prostate cancer…”
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Inhibition of the FGF/FGFR System Induces Apoptosis in Lung Cancer Cells via c-Myc Downregulation and Oxidative Stress by Giacomini, Arianna, Taranto, Sara, Rezzola, Sara, Matarazzo, Sara, Grillo, Elisabetta, Bugatti, Mattia, Scotuzzi, Alessia, Guerra, Jessica, Di Trani, Martina, Presta, Marco, Ronca, Roberto

“…Lung cancer represents an extremely diffused neoplastic disorder with different histological/molecular features. Among the different lung tumors,…”
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Discovery of novel FGF trap small molecules endowed with anti-myeloma activity by Taranto, Sara, Castelli, Riccardo, Marseglia, Giuseppe, Scalvini, Laura, Vacondio, Federica, Gianoncelli, Alessandra, Ribaudo, Giovanni, Faletti, Jessica, Gazzaroli, Giorgia, Rocca, Edoardo, Ronca, Roberto, Rusnati, Marco, Sacco, Antonio, Roccaro, Aldo Maria, Presta, Marco, Mor, Marco, Giacomini, Arianna, Rivara, Silvia

“…Fibroblast growth factors (FGFs) act as proangiogenic and mitogenic cytokines in several cancers, including multiple myeloma (MM). Indeed, corrupted FGF…”
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PTX3 Modulates Neovascularization and Immune Inflammatory Infiltrate in a Murine Model of Fibrosarcoma by Annese, Tiziana, Ronca, Roberto, Tamma, Roberto, Giacomini, Arianna, Ruggieri, Simona, Grillo, Elisabetta, Presta, Marco, Ribatti, Domenico

“…Fibrosarcoma is an aggressive subtype of soft tissue sarcoma categorized in infantile/congenital-type and adult-type. Fibrosarcoma cells and its surrounding…”
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The FGF/FGFR/c-Myc axis as a promising therapeutic target in multiple myeloma by Giacomini, Arianna, Taranto, Sara, Gazzaroli, Giorgia, Faletti, Jessica, Capoferri, Davide, Marcheselli, Raffaella, Sciumè, Margherita, Presta, Marco, Sacco, Antonio, Roccaro, Aldo M

“…Among blood cancers, multiple myeloma (MM) represents the second most common neoplasm and is characterized by the accumulation and proliferation of monoclonal…”
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Synthesis, Structural Elucidation, and Biological Evaluation of NSC12, an Orally Available Fibroblast Growth Factor (FGF) Ligand Trap for the Treatment of FGF-Dependent Lung Tumors by Castelli, Riccardo, Giacomini, Arianna, Anselmi, Mattia, Bozza, Nicole, Vacondio, Federica, Rivara, Silvia, Matarazzo, Sara, Presta, Marco, Mor, Marco, Ronca, Roberto

“…NSC12 is an orally available pan-FGF trap able to inhibit FGF2/FGFR interaction and endowed with promising antitumor activity. It was identified by virtual…”
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FGF-trapping hampers cancer stem-like cells in uveal melanoma by Loda, Alessandra, Calza, Stefano, Giacomini, Arianna, Ravelli, Cosetta, Krishna Chandran, Adwaid Manu, Tobia, Chiara, Tabellini, Giovanna, Parolini, Silvia, Semeraro, Francesco, Ronca, Roberto, Rezzola, Sara

“…Cancer stem-like cells (CSCs) are a subpopulation of tumor cells responsible for tumor initiation, metastasis, chemoresistance, and relapse. Recently, CSCs…”
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β-Galactosylceramidase Deficiency Causes Bone Marrow Vascular Defects in an Animal Model of Krabbe Disease by Belleri, Mirella, Coltrini, Daniela, Righi, Marco, Ravelli, Cosetta, Taranto, Sara, Chiodelli, Paola, Mitola, Stefania, Presta, Marco, Giacomini, Arianna

“…Krabbe disease (KD) is an autosomal recessive sphingolipidosis caused by the deficiency of the lysosomal hydrolase β-galactosylceramidase (GALC)…”
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The natural FGF-trap long pentraxin 3 inhibits lymphangiogenesis and lymphatic dissemination by Turati, Marta, Giacomini, Arianna, Rezzola, Sara, Maccarinelli, Federica, Gazzaroli, Giorgia, Valentino, Sonia, Bottazzi, Barbara, Presta, Marco, Ronca, Roberto

“…Abstract The lymphatic vascular system represents a major route for dissemination of several solid tumors, including melanoma. Even though the members of the…”
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The Antitumor Didox Acts as an Iron Chelator in Hepatocellular Carcinoma Cells by Asperti, Michela, Cantamessa, Luca, Ghidinelli, Simone, Gryzik, Magdalena, Denardo, Andrea, Giacomini, Arianna, Longhi, Giovanna, Fanzani, Alessandro, Arosio, Paolo, Poli, Maura

“…Ribonucleotide reductase (RR) is the rate-limiting enzyme that controls the deoxynucleotide triphosphate synthesis and it is an important target of cancer…”
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Long Pentraxin 3-Mediated Fibroblast Growth Factor Trapping Impairs Fibrosarcoma Growth by Rodrigues, Priscila Fabiana, Matarazzo, Sara, Maccarinelli, Federica, Foglio, Eleonora, Giacomini, Arianna, Silva Nunes, João Paulo, Presta, Marco, Dias, Adriana Abalen Martins, Ronca, Roberto

“…Fibrosarcomas are soft tissue mesenchymal tumors originating from transformed fibroblasts. Fibroblast growth factor-2 (FGF2) and its tyrosine-kinase receptors…”
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Targeting the Endothelin-1 Receptors Curtails Tumor Growth and Angiogenesis in Multiple Myeloma by Russignan, Anna, Dal Collo, Giada, Bagnato, Anna, Tamassia, Nicola, Bugatti, Mattia, Belleri, Mirella, Lorenzi, Luisa, Borsi, Enrica, Bazzoni, Riccardo, Gottardi, Michele, Terragna, Carolina, Vermi, William, Giacomini, Arianna, Presta, Marco, Cassatella, Marco Antonio, Krampera, Mauro, Tecchio, Cristina

“…The endothelin-1 (ET-1) receptors were recently found to mediate pro-survival functions in multiple myeloma (MM) cells in response to autocrine ET-1. This…”
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Iron supplementation enhances RSL3-induced ferroptosis to treat naïve and prevent castration-resistant prostate cancer by Maccarinelli, Federica, Coltrini, Daniela, Mussi, Silvia, Bugatti, Mattia, Turati, Marta, Chiodelli, Paola, Giacomini, Arianna, De Cillis, Floriana, Cattane, Nadia, Cattaneo, Annamaria, Ligresti, Alessia, Asperti, Michela, Poli, Maura, Vermi, William, Presta, Marco, Ronca, Roberto

“…Prostate cancer (PCa) is a leading cause of death in the male population commonly treated with androgen deprivation therapy that often relapses as…”
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The PTX3/TLR4 autocrine loop as a novel therapeutic target in triple negative breast cancer by Giacomini, Arianna, Turati, Marta, Grillo, Elisabetta, Rezzola, Sara, Ghedini, Gaia Cristina, Schuind, Ander Churruca, Foglio, Eleonora, Maccarinelli, Federica, Faletti, Jessica, Filiberti, Serena, Chambery, Angela, Valletta, Mariangela, Melocchi, Laura, Gofflot, Stephanie, Chiavarina, Barbara, Turtoi, Andrei, Presta, Marco, Ronca, Roberto

“…Abstract Background The pattern recognition receptor long pentraxin-3 (PTX3) plays conflicting roles in cancer by acting as an oncosuppressor or as a pro-tumor…”
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(3)D [corrected] quantification of tumor vasculature in lymphoma xenografts in NOD/SCID mice allows to detect differences among vascular-targeted therapies by Righi, Marco, Giacomini, Arianna, Cleris, Loredana, Carlo-Stella, Carmelo

“…Quantitative characterization of the in vivo effects of vascular-targeted therapies on tumor vessels is hampered by the absence of useful 3D vascular network…”
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