Integrating frontiers: a holistic, quantum and evolutionary approach to conquering cancer through systems biology and multidisciplinary synergy

Cancer therapy is facing increasingly significant challenges, marked by a wide range of techniques and research efforts centered around somatic mutations, precision oncology, and the vast amount of big data. Despite this abundance of information, the quest to cure cancer often seems more elusive, wi...

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Published in:	Frontiers in oncology Vol. 14; p. 1419599
Main Authors:	Casotti, Matheus Correia, Meira, Débora Dummer, Zetum, Aléxia Stefani Siqueira, Campanharo, Camilly Victória, da Silva, Danielle Ribeiro Campos, Giacinti, Giulia Maria, da Silva, Iris Moreira, Moura, João Augusto Diniz, Barbosa, Karen Ruth Michio, Altoé, Lorena Souza Castro, Mauricio, Lorena Souza Rittberg, Góes, Luíza Santa Brígida de Barros, Alves, Lyvia Neves Rebello, Linhares, Sarah Sophia Guedes, Ventorim, Vinícius do Prado, Guaitolini, Yasmin Moreto, Dos Santos, Eldamária de Vargas Wolfgramm, Errera, Flavia Imbroisi Valle, Groisman, Sonia, de Carvalho, Elizeu Fagundes, de Paula, Flavia, de Sousa, Marcelo Victor Pires, Fechine, Pierre Basílio Almeida, Louro, Iuri Drumond
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 19-08-2024
Subjects:	biological evolution carcinogenesis chaos and quantum theory dynamics neoplasms Oncology translational science biological evolution dynamics carcinogenesis chaos and quantum theory neoplasms translational science
Online Access:	Get full text
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Summary:	Cancer therapy is facing increasingly significant challenges, marked by a wide range of techniques and research efforts centered around somatic mutations, precision oncology, and the vast amount of big data. Despite this abundance of information, the quest to cure cancer often seems more elusive, with the "war on cancer" yet to deliver a definitive victory. A particularly pressing issue is the development of tumor treatment resistance, highlighting the urgent need for innovative approaches. Evolutionary, Quantum Biology and System Biology offer a promising framework for advancing experimental cancer research. By integrating theoretical studies, translational methods, and flexible multidisciplinary clinical research, there's potential to enhance current treatment strategies and improve outcomes for cancer patients. Establishing stronger links between evolutionary, quantum, entropy and chaos principles and oncology could lead to more effective treatments that leverage an understanding of the tumor's evolutionary dynamics, paving the way for novel methods to control and mitigate cancer. Achieving these objectives necessitates a commitment to multidisciplinary and interprofessional collaboration at the heart of both research and clinical endeavors in oncology. This entails dismantling silos between disciplines, encouraging open communication and data sharing, and integrating diverse viewpoints and expertise from the outset of research projects. Being receptive to new scientific discoveries and responsive to how patients react to treatments is also crucial. Such strategies are key to keeping the field of oncology at the forefront of effective cancer management, ensuring patients receive the most personalized and effective care. Ultimately, this approach aims to push the boundaries of cancer understanding, treating it as a manageable chronic condition, aiming to extend life expectancy and enhance patient quality of life.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 Reviewed by: Sushil Shakyawar, University of Nebraska Medical Center, United States These authors have contributed equally to this work Edited by: Cecilia Ana Suarez, National Scientific and Technical Research Council (CONICET), Argentina Georgia Tourassi, Oak Ridge National Laboratory (DOE), United States
ISSN:	2234-943X 2234-943X
DOI:	10.3389/fonc.2024.1419599