Search Results - "Giachino, Claudio"

Id4 Downstream of Notch2 Maintains Neural Stem Cell Quiescence in the Adult Hippocampus by Zhang, Runrui, Boareto, Marcelo, Engler, Anna, Louvi, Angeliki, Giachino, Claudio, Iber, Dagmar, Taylor, Verdon

“…Neural stem cells (NSCs) in the adult mouse hippocampal dentate gyrus (DG) are mostly quiescent, and only a few are in cell cycle at any point in time. DG NSCs…”
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Oncogenic and Tumor-Suppressive Functions of NOTCH Signaling in Glioma by Parmigiani, Elena, Taylor, Verdon, Giachino, Claudio

“…Although the role of NOTCH signaling has been extensively studied in health and disease, many questions still remain unresolved. Being crucial for tissue…”
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Notch2 Signaling Maintains NSC Quiescence in the Murine Ventricular-Subventricular Zone by Engler, Anna, Rolando, Chiara, Giachino, Claudio, Saotome, Ichiko, Erni, Andrea, Brien, Callum, Zhang, Runrui, Zimber-Strobl, Ursula, Radtke, Freddy, Artavanis-Tsakonas, Spyros, Louvi, Angeliki, Taylor, Verdon

“…Neurogenesis continues in the ventricular-subventricular zone (V-SVZ) of the adult forebrain from quiescent neural stem cells (NSCs). V-SVZ NSCs are a…”
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A Tumor Suppressor Function for Notch Signaling in Forebrain Tumor Subtypes by Giachino, Claudio, Boulay, Jean-Louis, Ivanek, Robert, Alvarado, Alvaro, Tostado, Cristobal, Lugert, Sebastian, Tchorz, Jan, Coban, Mustafa, Mariani, Luigi, Bettler, Bernhard, Lathia, Justin, Frank, Stephan, Pfister, Stefan, Kool, Marcel, Taylor, Verdon

“…In the brain, Notch signaling maintains normal neural stem cells, but also brain cancer stem cells, indicating an oncogenic role. Here, we identify an…”
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Molecular Diversity Subdivides the Adult Forebrain Neural Stem Cell Population by Giachino, Claudio, Basak, Onur, Lugert, Sebastian, Knuckles, Philip, Obernier, Kirsten, Fiorelli, Roberto, Frank, Stephan, Raineteau, Olivier, Alvarez‐Buylla, Arturo, Taylor, Verdon

“…Neural stem cells (NSCs) in the ventricular domain of the subventricular zone (V‐SVZ) of rodents produce neurons throughout life while those in humans become…”
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SAFB regulates hippocampal stem cell fate by targeting Drosha to destabilize Nfib mRNA by Forcella, Pascal, Ifflander, Niklas, Rolando, Chiara, Balta, Elli-Anna, Lampada, Aikaterini, Giachino, Claudio, Mukhtar, Tanzila, Bock, Thomas, Taylor, Verdon

“…Neural stem cells (NSCs) are multipotent and correct fate determination is crucial to guarantee brain formation and homeostasis. How NSCs are instructed to…”
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Chain formation and glial tube assembly in the shift from neonatal to adult subventricular zone of the rodent forebrain by Peretto, Paolo, Giachino, Claudio, Aimar, Patrizia, Fasolo, Aldo, Bonfanti, Luca

“…The subventricular zone (SVZ) is regarded as an embryonic germinal layer persisting at the end of cerebral cortex neurogenesis and capable of generating…”
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A modified RMCE-compatible Rosa26 locus for the expression of transgenes from exogenous promoters by Tchorz, Jan S, Suply, Thomas, Ksiazek, Iwona, Giachino, Claudio, Cloëtta, Dimitri, Danzer, Claus-Peter, Doll, Thierry, Isken, Andrea, Lemaistre, Marianne, Taylor, Verdon, Bettler, Bernhard, Kinzel, Bernd, Mueller, Matthias

“…Generation of gain-of-function transgenic mice by targeting the Rosa26 locus has been established as an alternative to classical transgenic mice produced by…”
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cAMP Response Element-Binding Protein Regulates Differentiation and Survival of Newborn Neurons in the Olfactory Bulb by Giachino, Claudio, De Marchis, Silvia, Giampietro, Costanza, Parlato, Rosanna, Perroteau, Isabelle, Schutz, Gunther, Fasolo, Aldo, Peretto, Paolo

“…The transcription factor cAMP response element-binding protein (CREB) is involved in multiple aspects of neuronal development and plasticity. Here, we…”
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Newborn interneurons in the accessory olfactory bulb promote mate recognition in female mice by Oboti, Livio, Schellino, Roberta, Giachino, Claudio, Chamero, Pablo, Pyrski, Martina, Leinders-Zufall, Trese, Zufall, Frank, Fasolo, Aldo, Peretto, Paolo

“…In the olfactory bulb of adult rodents, local interneurons are constantly replaced by immature precursors derived from the subventricular zone. Whether any…”
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Genetic Inactivation of Notch1 Synergizes with Loss of Trp53 to Induce Tumor Formation in the Adult Mouse Forebrain by Parmigiani, Elena, Giachino, Claudio

“…Simultaneous genetic inactivation of the key Notch signaling mediator RBP-Jk and p53 leads to the formation of forebrain tumors in mice, suggesting a tumor…”
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Genetic Inactivation of INotch1/I Synergizes with Loss of ITrp53/I to Induce Tumor Formation in the Adult Mouse Forebrain by Parmigiani, Elena, Giachino, Claudio

“…Notch signaling plays a context-dependent role in multiple cancer types by either promoting or suppressing tumor development. The role of the Notch receptors…”
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Lineage analysis of quiescent regenerative stem cells in the adult brain by genetic labelling reveals spatially restricted neurogenic niches in the olfactory bulb by Giachino, Claudio, Taylor, Verdon

“…The subventricular zone (SVZ) of the lateral ventricles is the major neurogenic region in the adult mammalian brain, harbouring neural stem cells within…”
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Neurogenic subventricular zone stem/progenitor cells are Notch1-dependent in their active but not quiescent state by Basak, Onur, Giachino, Claudio, Fiorini, Emma, Macdonald, H Robson, Taylor, Verdon

“…The adult mammalian forebrain contains neural stem/progenitor cells (NSCs) that generate neurons throughout life. As in other somatic stem cell systems, NSCs…”
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Quiescent and Active Hippocampal Neural Stem Cells with Distinct Morphologies Respond Selectively to Physiological and Pathological Stimuli and Aging by Lugert, Sebastian, Basak, Onur, Knuckles, Philip, Haussler, Ute, Fabel, Klaus, Götz, Magdalena, Haas, Carola A., Kempermann, Gerd, Taylor, Verdon, Giachino, Claudio

“…New neurons are generated in the adult hippocampus throughout life by neural stem/progenitor cells (NSCs), and neurogenesis is a plastic process responsive to…”
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GABA suppresses neurogenesis in the adult hippocampus through GABAB receptors by Giachino, Claudio, Barz, Michael, Tchorz, Jan S, Tome, Mercedes, Gassmann, Martin, Bischofberger, Josef, Bettler, Bernhard, Taylor, Verdon

“…Adult neurogenesis is tightly regulated through the interaction of neural stem/progenitor cells (NSCs) with their niche. Neurotransmitters, including GABA…”
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Hippocampal development and neural stem cell maintenance require Sox2 -dependent regulation of Shh by Ottolenghi, Sergio, Tosetti, Valentina, Nicolis, Silvia K, Latorre, Elisa, Giachino, Claudio, Lancini, Cesare, Valotta, Menella, Ferri, Anna L M, Favaro, Rebecca, Mariani, Jessica, Taylor, Verdon

“…Deleting the transcription factor SOX2 in mouse embryonic brain causes a loss of neural stem cells and neurogenesis in the hippocampus. An SHH pharmacological…”
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RBPJκ-Dependent Signaling Is Essential for Long-Term Maintenance of Neural Stem Cells in the Adult Hippocampus by Ehm, Oliver, Göritz, Christian, Covic, Marcela, Schäffner, Iris, Schwarz, Tobias J., Karaca, Esra, Kempkes, Bettina, Kremmer, Elisabeth, Pfrieger, Frank W., Espinosa, Lluis, Bigas, Anna, Giachino, Claudio, Taylor, Verdon, Frisén, Jonas, Lie, D. Chichung

“…The generation of new neurons from neural stem cells in the adult hippocampal dentate gyrus contributes to learning and mood regulation. To sustain hippocampal…”
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Interferon-γ resistance and immune evasion in glioma develop via Notch-regulated co-evolution of malignant and immune cells by Parmigiani, Elena, Ivanek, Robert, Rolando, Chiara, Hafen, Katrin, Turchinovich, Gleb, Lehmann, Frank Michael, Gerber, Alexandra, Brkic, Sime, Frank, Stephan, Meyer, Sara C., Wakimoto, Hiroaki, Günel, Murat, Louvi, Angeliki, Mariani, Luigi, Finke, Daniela, Holländer, Georg, Hutter, Gregor, Tussiwand, Roxane, Taylor, Verdon, Giachino, Claudio

“…Immune surveillance is critical to prevent tumorigenesis. Gliomas evade immune attack, but the underlying mechanisms remain poorly understood. We show that…”
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An In Vivo CRISPR Screen Identifies Stepwise Genetic Dependencies of Metastatic Progression by Scheidmann, Manuel C, Castro-Giner, Francesc, Strittmatter, Karin, Krol, Ilona, Paasinen-Sohns, Aino, Scherrer, Ramona, Donato, Cinzia, Gkountela, Sofia, Szczerba, Barbara M, Diamantopoulou, Zoi, Muenst, Simone, Vlajnic, Tatjana, Kunz, Leo, Vetter, Marcus, Rochlitz, Christoph, Taylor, Verdon, Giachino, Claudio, Schroeder, Timm, Platt, Randall J, Aceto, Nicola

“…Blood-borne metastasis of breast cancer involves a series of tightly regulated sequential steps, including the growth of a primary tumor lesion, intravasation…”
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