Pediatric intervertebral disc calcification: case series and systematic review of the literature
Pediatric intervertebral disc calcification (PIDC) is an uncommon disease with an unclear etiology. The clinical picture may suggest a severe spinal disease, thus involving an extensive differential diagnosis. The aim of this study was to find a diagnostic and treatment approach for PIDC on the basi...
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| Published in: | Journal of pediatric orthopaedics. B Vol. 29; no. 6; pp. 590 - 598 |
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| Main Authors: | , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
Wolters Kluwer Health, Inc. All rights reserved
01-11-2020
Copyright Wolters Kluwer Health, Inc. All rights reserved |
| Online Access: | Get full text |
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| Summary: | Pediatric intervertebral disc calcification (PIDC) is an uncommon disease with an unclear etiology. The clinical picture may suggest a severe spinal disease, thus involving an extensive differential diagnosis. The aim of this study was to find a diagnostic and treatment approach for PIDC on the basis of the literature. The Medline, Embase, Web of Science, and Cochrane Systematic Review databases were searched for relevant studies, whose reference lists were checked manually for additional articles. For each study, year of publication, study design, demographics, onset type, history of trauma, clinical and neurological signs and symptoms, imaging studies performed, blood test results, treatment strategies, and outcomes were recorded. The charts of eight patients with symptomatic PIDC treated at our institution from 2000 to 2016 were reviewed. Of 1522 articles identified by the search, 51 level IV studies involving 91 patients fulfilled the inclusion criteria. Most patients were treated conservatively and achieved complete recovery. Of the 13 patients who were treated surgically, one had a persistent myelopathy at the final follow-up. All the patients of our case series were treated conservatively and achieved complete symptom resolution at the final follow-up. PIDC is predominantly a benign and self-limiting condition. Surgery should be considered only in case of failure of conservative treatment in the presence of severe neurological impairment and myelopathy. Level of EvidenceIV (case series and systematic review of level IV studies). |
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| Bibliography: | ObjectType-Case Study-3 SourceType-Scholarly Journals-1 content type line 23 ObjectType-Feature-5 ObjectType-Undefined-1 ObjectType-Report-2 ObjectType-Article-4 |
| ISSN: | 1060-152X 1473-5865 |
| DOI: | 10.1097/BPB.0000000000000638 |