Search Results - "Ghyselinck, N"

A directional strategy for monitoring Cre-mediated recombination at the cellular level in the mouse by Ghyselinck, Norbert B, Schnütgen, Frank, Doerflinger, Nathalie, Wendling, Olivia, Calléja, Cécile, Chambon, Pierre

“…Functional redundancies, compensatory mechanisms, and lethal phenotypes often prevent the full analysis of gene functions through generation of germline null…”
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Cellular retinol-binding protein I is essential for vitamin A homeostasis by Ghyselinck, Norbert B., Båvik, Claes, Sapin, Vincent, Mark, Manuel, Bonnier, Dominique, Hindelang, Colette, Dierich, Andrée, Nilsson, Charlotte B., Håkansson, Helen, Sauvant, Patrick, Azaïs-Braesco, Véronique, Frasson, Maria, Picaud, Serge, Chambon, Pierre

“…The gene encoding cellular retinol (ROL, vitA)‐binding protein type I (CRBPI) has been inactivated. Mutant mice fed a vitA‐enriched diet are healthy and…”
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[OP.3A.02] RETINOIC ACID RECEPTOR SIGNALING CONTRIBUTES TO ADRENAL CORTEX MORPHOLOGY AND FUNCTIONAL ZONATION by Boulkroun, S, Rickard, A, Dzib, J Golib, Samson-couterie, B, Rocha, A, Gomez-sanchez, C, Amar, L, Fernandes-rosa, F, Ghyselinck, N, Benecke, A, Lalli, E, Zennaro, M.-C

“…OBJECTIVE:Recurrent somatic mutations in KCNJ5, CACNA1D, ATP1A1 and ATP2B3 have been identified in aldosterone producing adenoma (APA). Although the role of…”
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Retinoids enhance glucocorticoid-induced apoptosis of T cells by facilitating glucocorticoid receptor-mediated transcription by Tóth, K, Sarang, Z, Scholtz, B, Brázda, P, Ghyselinck, N, Chambon, P, Fésüs, L, Szondy, Z

“…Glucocorticoid-induced apoptosis of thymocytes is one of the first recognized forms of programmed cell death. It was shown to require gene activation induced…”
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Systematic Immunolocalization of Retinoid Receptors in Developing and Adult Mouse Eyes by Mori, Mikiro, Ghyselinck, Norbert B, Chambon, Pierre, Mark, Manuel

“…To determine the localization of retinoic acid receptors (RAR) alpha, beta, and gamma and retinoid X receptors (RXR) alpha, beta, and gamma in developing and…”
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Roles of retinoic acid receptors in early embryonic morphogenesis and hindbrain patterning by Wendling, O, Ghyselinck, N B, Chambon, P, Mark, M

“…Mutants mice carrying targeted inactivations of both retinoic acid receptor (RAR) α and RARγ (Aα/Aγ mutants) were analyzed at different embryonic stages,…”
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Genetic evidence that the retinoid signal is transduced by heterodimeric RXR/RAR functional units during mouse development by Kastner, P, Mark, M, Ghyselinck, N, Krezel, W, Dupé, V, Grondona, J M, Chambon, P

“…We describe here the analysis of congenital malformations in compound mutant fetuses bearing null alleles in one RXR (alpha, beta or gamma) and one RAR (alpha,…”
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A Newborn Lethal Defect Due to Inactivation of Retinaldehyde Dehydrogenase Type 3 Is Prevented by Maternal Retinoic Acid Treatment by Dupé, Valérie, Matt, Nicolas, Garnier, Jean-Marie, Chambon, Pierre, Mark, Manuel, Ghyselinck, Norbert B.

“…The retinoic acid (RA) signal, produced locally from vitamin A by retinaldehyde dehydrogenase (Raldh) and transduced by the nuclear receptors for retinoids (RA…”
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Retinoic acid signalling in the development of branchial arches by Mark, Manuel, Ghyselinck, Norbert B, Chambon, Pierre

“…Branchial arches develop through a complex sequence of interactions between migrating cells, derived from neural crest and mesoderm, and epithelia of…”
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Retinoic acid-induced developmental defects are mediated by RARβ/RXR heterodimers in the pharyngeal endoderm by Matt, Nicolas, Ghyselinck, Norbert B., Wendling, Olivia, Chambon, Pierre, Mark, Manuel

“…Fusion and hypoplasia of the first two branchial arches, a defect typically observed in retinoic acid (RA) embryopathy, is generated in cultured mouse embryos…”
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Stage-dependent responses of the developing lung to retinoic acid signaling by Mollard, R, Ghyselinck, N B, Wendling, O, Chambon, P, Mark, M

“…Morphological analysis of vitamin A-deficient rat fetuses and of retinoic acid receptor (RAR and RXR) mutant mice have demonstrated that retinoic acid (RA) is…”
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Differential contributions of AF-1 and AF-2 activities to the developmental functions of RXR alpha by Mascrez, B, Mark, M, Krezel, W, Dupé, V, LeMeur, M, Ghyselinck, N B, Chambon, P

“…We have engineered a mouse mutation that specifically deletes most of the RXR alpha N-terminal A/B region, which includes the activation function AF-1 and…”
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Retinoic acid receptor-beta: an endogenous inhibitor of the perinatal formation of pulmonary alveoli by Massaro, G D, Massaro, D, Chan, W Y, Clerch, L B, Ghyselinck, N, Chambon, P, Chandraratna, R A

“…Pulmonary alveoli are formed, in part, by subdivision (septation) of the gas-exchange saccules of the immature lung. Septation is developmentally regulated,…”
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Physiological and retinoid-induced proliferations of epidermis basal keratinocytes are differently controlled by Chapellier, Benoit, Mark, Manuel, Messaddeq, Nadia, Calléja, Cécile, Warot, Xavier, Brocard, Jacques, Gérard, Christelle, Li, Mei, Metzger, Daniel, Ghyselinck, Norbert B., Chambon, Pierre

“…To investigate the roles of retinoic acid (RA) receptors (RARs) in the physiology of epidermis that does not express RARβ, conditional spatio‐temporally…”
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Cellular Retinol-Binding Protein I, a Regulator of Breast Epithelial Retinoic Acid Receptor Activity, Cell Differentiation, and Tumorigenicity by Farias, Eduardo F., Ong, David E., Ghyselinck, Norbert B., Nakajo, Shigeo, Kuppumbatti, Yuvarani S., Mira y Lopez, Rafael

“…Background: Retinoic acid receptor (RAR) activation induces cell differentiation and may antagonize cancer progression. Cellular retinol-binding protein I…”
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Key roles of retinoic acid receptors alpha and beta in the patterning of the caudal hindbrain, pharyngeal arches and otocyst in the mouse by Dupé, V, Ghyselinck, N B, Wendling, O, Chambon, P, Mark, M

“…Mouse fetuses carrying targeted inactivations of both the RAR(α) and the RARbeta genes display a variety of malformations in structures known to be partially…”
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The RXRα ligand-dependent activation function 2 (AF-2) is important for mouse development by Mascrez, Bénédicte, Mark, Manuel, Dierich, Andrée, Ghyselinck, Norbert B., Kastner, Philippe, Chambon, Pierre

“…ABSTRACT We have engineered a mouse mutation that specifically deletes the C-terminal 18 amino acid sequence of the RXRα protein. This deletion corresponds to…”
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O-133 Retinoic acid has an essential role in meiotic progression beyond the zygotene stage in mouse testis by Condrea, D, Souali-Crespo, S, Féret, B, Klopfenstein, M, Haili, Z, Grandgirard, E, Messaddeq, N, Teletin, M, Ghyselinck, N B, Vernet, N

“…Abstract Study question Is all-trans retinoic acid (ATRA) instrumental to male germ cell differentiation in the mouse beyond the A1 spermatogonia cell stage?…”
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Structural organization and regulation of the gene for the androgen-dependent glutathione peroxidase-like protein specific to the mouse epididymis by Ghyselinck, N B, Dufaure, I, Lareyre, J J, Rigaudière, N, Mattéi, M G, Dufaure, J P

“…Genomic clones containing the gene for the glutathione peroxidase-like androgen-regulated murine epididymal protein of 24 kilodaltons (arMEP24) were isolated…”
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Role of the retinoic acid receptor beta (RARbeta) during mouse development by Ghyselinck, N B, Dupé, V, Dierich, A, Messaddeq, N, Garnier, J M, Rochette-Egly, C, Chambon, P, Mark, M

“…Homozygous RAR beta mutants are growth-deficient, but are fertile and have a normal longevity. They display homeotic transformations and malformations of…”
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