Search Results - "Ghulam Muhammad, A K M"

Human Flt3L generates dendritic cells from canine peripheral blood precursors: implications for a dog glioma clinical trial by Xiong, Weidong, Candolfi, Marianela, Liu, Chunyan, Muhammad, A K M Ghulam, Yagiz, Kader, Puntel, Mariana, Moore, Peter F, Avalos, Julie, Young, John D, Khan, Dorothy, Donelson, Randy, Pluhar, G Elizabeth, Ohlfest, John R, Wawrowsky, Kolja, Lowenstein, Pedro R, Castro, Maria G

“…Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults and carries a dismal prognosis. We have developed a conditional…”
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HMGB1 mediates endogenous TLR2 activation and brain tumor regression by Curtin, James F, Liu, Naiyou, Candolfi, Marianela, Xiong, Weidong, Assi, Hikmat, Yagiz, Kader, Edwards, Matthew R, Michelsen, Kathrin S, Kroeger, Kurt M, Liu, Chunyan, Muhammad, A K M Ghulam, Clark, Mary C, Arditi, Moshe, Comin-Anduix, Begonya, Ribas, Antoni, Lowenstein, Pedro R, Castro, Maria G

“…Glioblastoma multiforme (GBM) is the most aggressive primary brain tumor that carries a 5-y survival rate of 5%. Attempts at eliciting a clinically relevant…”
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High-Capacity Adenovirus Vector-Mediated Anti-Glioma Gene Therapy in the Presence of Systemic Antiadenovirus Immunity by KING, Gwendalyn D, GHULAM MUHAMMAD, A. K. M, WEIDONG XIONG, KROEGER, Kurt M, PUNTEL, Mariana, LAROCQUE, Daniel, PALMER, Donna, NG, Philip, LOWENSTEIN, Pedro R, CASTRO, Maria G

“…Erratum ( vol. 82 , p. 6087 ) Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious…”
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Release of HMGB1 in Response to Proapoptotic Glioma Killing Strategies: Efficacy and Neurotoxicity by CANDOLFI, Marianela, YAGIZ, Kader, CURTIN, James F, KING, Gwendalyn D, LERNER, Jonathan, SATO, Katsuaki, MINEHARU, Yohei, WEIDONG XIONG, LOWENSTEIN, Pedro R, CASTRO, Maria G, FOULAD, David, ALZADEH, Gabrielle E, TESARFREUND, Matthew, GHULAM MUHAMMAD, A. K. M, PUNTEL, Mariana, KROEGER, Kurt M, CHUNYAN LIU, LEE, Sharon

“…Purpose: In preparation for a phase I clinical trial using a combined cytotoxic/immunotherapeutic strategy with adenoviruses (Ad) expressing Flt3L (Ad-Flt3L)…”
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Gene therapy and targeted toxins for glioma by Castro, Maria G, Candolfi, Marianela, Kroeger, Kurt, King, Gwendalyn D, Curtin, James F, Yagiz, Kader, Mineharu, Yohei, Assi, Hikmat, Wibowo, Mia, Ghulam Muhammad, A K M, Foulad, David, Puntel, Mariana, Lowenstein, Pedro R

“…The most common primary brain tumor in adults is glioblastoma. These tumors are highly invasive and aggressive with a mean survival time of 15-18 months from…”
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Safety profile, efficacy, and biodistribution of a bicistronic high-capacity adenovirus vector encoding a combined immunostimulation and cytotoxic gene therapy as a prelude to a phase I clinical trial for glioblastoma by Puntel, Mariana, A.K.M., Ghulam Muhammad, Farrokhi, Catherine, VanderVeen, Nathan, Paran, Christopher, Appelhans, Ashley, Kroeger, Kurt M., Salem, Alireza, Lacayo, Liliana, Pechnick, Robert N., Kelson, Kyle R., Kaur, Sukhpreet, Kennedy, Sean, Palmer, Donna, Ng, Philip, Liu, Chunyan, Krasinkiewicz, Johnny, Lowenstein, Pedro R., Castro, Maria G.

“…Adenoviral vectors (Ads) are promising gene delivery vehicles due to their high transduction efficiency; however, their clinical usefulness has been hampered…”
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Combined Flt3L/TK Gene Therapy Induces Immunological Surveillance Which Mediates an Immune Response Against a Surrogate Brain Tumor Neoantigen by King, Gwendalyn D, Muhammad, AKM Ghulam, Larocque, Daniel, Kelson, Kyle R, Xiong, Weidong, Liu, Chunyan, Sanderson, Nicholas SR, Kroeger, Kurt M, Castro, Maria G, Lowenstein, Pedro R

“…Glioblastoma multiforme (GBM) is a primary brain tumor with a median survival of 14.6 months postdiagnosis. The infiltrative nature of GBM prevents complete…”
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C9orf72 deficiency promotes microglial-mediated synaptic loss in aging and amyloid accumulation by Lall, Deepti, Lorenzini, Ileana, Mota, Thomas A., Bell, Shaughn, Mahan, Thomas E., Ulrich, Jason D., Davtyan, Hayk, Rexach, Jessica E., Muhammad, A.K.M. Ghulam, Shelest, Oksana, Landeros, Jesse, Vazquez, Michael, Kim, Junwon, Ghaffari, Layla, O’Rourke, Jacqueline Gire, Geschwind, Daniel H., Blurton-Jones, Mathew, Holtzman, David M., Sattler, Rita, Baloh, Robert H.

“…C9orf72 repeat expansions cause inherited amyotrophic lateral sclerosis (ALS)/frontotemporal dementia (FTD) and result in both loss of C9orf72 protein…”
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Safety profile of gutless adenovirus vectors delivered into the normal brain parenchyma: implications for a glioma phase 1 clinical trial by Muhammad, A K M Ghulam, Xiong, Weidong, Puntel, Mariana, Farrokhi, Catherine, Kroeger, Kurt M, Salem, Alireza, Lacayo, Liliana, Pechnick, Robert N, Kelson, Kyle R, Palmer, Donna, Ng, Philip, Liu, Chunyan, Lowenstein, Pedro R, Castro, Maria G

“…Adenoviral vectors (Ads) have been evaluated in clinical trials for glioma. However, systemic immunity against the vectors can hamper therapeutic efficacy. We…”
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Gene Therapy-Mediated Reprogramming Tumor Infiltrating T Cells Using IL-2 and Inhibiting NF-κB Signaling Improves the Efficacy of Immunotherapy in a Brain Cancer Model by Mineharu, Yohei, Muhammad, AKM Ghulam, Yagiz, Kader, Candolfi, Marianela, Kroeger, Kurt M., Xiong, Weidong, Puntel, Mariana, Liu, Chunyan, Levy, Eva, Lugo, Claudia, Kocharian, Adrina, Allison, James P., Curran, Michael A., Lowenstein, Pedro R., Castro, Maria G.

“…Immune-mediated gene therapy using adenovirus expressing Flt3 ligand and thymidine kinase followed by ganciclovir administration (Flt3/TK) effectively elicits…”
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Antiglioma Immunological Memory in Response to Conditional Cytotoxic/Immune-Stimulatory Gene Therapy: Humoral and Cellular Immunity Lead to Tumor Regression by Ghulam Muhammad, A K M, Candolfi, Marianela, King, Gwendalyn D, Yagiz, Kader, Foulad, David, Mineharu, Yohei, Kroeger, Kurt M, Treuer, Katherine A, Nichols, W Stephen, Sanderson, Nicholas S, Yang, Jieping, Khayznikov, Maksim, Van Rooijen, Nico, Lowenstein, Pedro R, Castro, Maria G

“…Purpose: Glioblastoma multiforme is a deadly primary brain cancer. Because the tumor kills due to recurrences, we tested the hypothesis that a new treatment…”
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Plasmacytoid Dendritic Cells in the Tumor Microenvironment: Immune Targets for Glioma Therapeutics by Candolfi, Marianela, King, Gwendalyn D, Yagiz, Kader, Curtin, James F, Mineharu, Yohei, Muhammad, AKM Ghulam, Foulad, David, Kroeger, Kurt M, Barnett, Nick, Josien, Regis, Lowenstein, Pedro R, Castro, Maria G

“…Abstract Adenovirus-mediated delivery of the immune-stimulatory cytokine Flt3L and the conditionally cytotoxic thymidine kinase (TK) induces tumor regression…”
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Giant cell type of primary intracranial malignant fibrous histiocytoma: a case report by Maruno, Motohiko, Ghulam Muhammad, A K M, Taguchi, Junji, Suzuki, Tsuyoshi, Wada, Kouichi, Isaka, Toshihiko, Yoshimine, Toshiki

“…The primary intracranial giant cell type of malignant fibrous histiocytoma (GC-MFH) is rare, and the resemblance to meningioma causes diagnostic confusion…”
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Gene therapy and virotherapy: novel therapeutic approaches for brain tumors by Kroeger, Kurt M, Muhammad, A K M Ghulam, Baker, Gregory J, Assi, Hikmat, Wibowo, Mia K, Xiong, Weidong, Yagiz, Kader, Candolfi, Marianela, Lowenstein, Pedro R, Castro, Maria G

“…Glioblastoma multiforme (GBM) is a deadly primary brain tumor in adults, with a median survival of ~12-18 months post-diagnosis. Despite recent advances in…”
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Optimization of adenoviral vector-mediated transgene expression in the canine brain in vivo, and in canine glioma cells in vitro by Candolfi, Marianela, Pluhar, G Elizabeth, Kroeger, Kurt, Puntel, Mariana, Curtin, James, Barcia, Carlos, Muhammad, A K M Ghulam, Xiong, Weidong, Liu, Chunyan, Mondkar, Sonali, Kuoy, William, Kang, Terry, McNeil, Elizabeth A, Freese, Andrew B, Ohlfest, John R, Moore, Peter, Palmer, Donna, Ng, Phillip, Young, John D, Lowenstein, Pedro R, Castro, Maria G

“…Expression of the immune-stimulatory molecule Fms-like tyrosine kinase 3 ligand (Flt3L) and the conditional cytotoxic enzyme herpes simplex virus type 1…”
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Whole-genome analysis of human astrocytic tumors by comparative genomic hybridization by Maruno, M, Ninomiya, H, Ghulam Muhammad, A K, Hirata, M, Kato, A, Yoshimine, T

“…Frozen sections of 35 astrocytic tumors of various histologic malignancies were analyzed by comparative genomic hybridization in an attempt to characterize the…”
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Chromosome 22q Allelic Losses at Microsatellite Loci in Human Astrocytic Tumors by A. K. M. Ghulam MUHAMMAD, YOSHIMINE, Toshiki, MARUNO, Motohiko, TOKIYOSHI, Koji, TAKEMOTO, Osamu, HAYAKAWA, Toru

“…Common regions of deletion(s) on chromosome 22q and the correlations between loss of heterozygosity and patient survival were analyzed in 19 deoxyribonucleic…”
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Ultrastructural changes of the vascular endothelium after intra-arterial administration of tumor necrosis factor-alpha (TNFα) in rat gliomas by ISAKA, T, MARUNO, M, GHULAM MUHAMMAD, A. K. M, KATO, A, NAKAGAWA, H, YOSHIMINE, T

“…The ensuing ultrastructural changes in tumor vascular endothelial cells following intra-arterial administration of tumor necrosis factor-alpha (TNFalpha) were…”
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Flt3L and TK gene therapy eradicate multifocal glioma in a syngeneic glioblastoma model by King, Gwendalyn D, Muhammad, A K M Ghulam, Curtin, James F, Barcia, Carlos, Puntel, Mariana, Liu, Chunyan, Honig, Sarah B, Candolfi, Marianela, Mondkar, Sonali, Lowenstein, Pedro R, Castro, Maria G

“…The disseminated characteristics of human glioblastoma multiforme (GBM) make it a particularly difficult tumor to treat with long-term efficacy. Most…”
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Flt3L in Combination With HSV1-TK-mediated Gene Therapy Reverses Brain Tumor–induced Behavioral Deficits by King, Gwendalyn D, Kroeger, Kurt M, Bresee, Catherine J, Candolfi, Marianela, Liu, Chunyan, Manalo, Charlene M, Muhammad, AKM Ghulam, Pechnick, Robert N, Lowenstein, Pedro R, Castro, Maria G

“…Glioblastoma multiforme (GBM) is an invasive and aggressive primary brain tumor which is associated with a dismal prognosis. We have earlier developed a…”
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