Search Results - "Ghufran, Mehreen"

Polyphenol-enriched Desmodium elegans DC. ameliorate scopolamine-induced amnesia in animal model of Alzheimer’s disease: In Vitro, In Vivo and In Silico approaches by Mahnashi, Mater H., Ashraf, Muhammad, Alhasaniah, Abdulaziz Hassan, Ullah, Hammad, Zeb, Alam, Ghufran, Mehreen, Fahad, Shah, Ayaz, Muhammad, Daglia, Maria

“…The current study aims to quantify HPLC-DAD polyphenolics in the crude extracts of Desmodium elegans, evaluating its cholinesterase inhibitory, antioxidant,…”
Get full text

In-depth in-vitro and in-vivo anti-diabetic evaluations of Fagonia cretica mediated biosynthesized selenium nanoparticles by Khan, Haider Ali, Ghufran, Mehreen, Shams, Sulaiman, Jamal, Alam, Ayaz, Muhammad, Ullah, Mehran, Khan, Abbas, Khan, Mohammad Imran, Awan, Zuhier A.

“…Therapeutic moieties derived from medicinal plants as well as plants-based ecofriendly processes for producing selenium nanoparticles have shown great promise…”
Get full text

Green synthesis of silver nanoparticles from plant Fagonia cretica and evaluating its anti-diabetic activity through indepth in-vitro and in-vivo analysis by Khan, Haider Ali, Ghufran, Mehreen, Shams, Sulaiman, Jamal, Alam, Khan, Abbas, Abdullah, Awan, Zuhier A., Khan, Mohammad Imran

“…One of the most widespread metabolic diseases, Type-2 Diabetes Mellitus (T2DM) is defined by high blood sugar levels brought on by decreased insulin secretion,…”
Get full text

In silico identification of promiscuous scaffolds as potential inhibitors of 1-deoxy-d-xylulose 5-phosphate reductoisomerase for treatment of Falciparum malaria by Wadood, Abdul, Ghufran, Mehreen, Hassan, Syed Fahad, Khan, Huma, Azam, Syed Sikandar, Rashid, Umer

“…Context: Malaria remains one of the prevalent infectious diseases worldwide. Plasmodium falciparum 1-deoxy-d-xylulose-5-phosphate reductoisomerase (PfDXR)…”
Get full text

In-Silico Lead Druggable Compounds Identification against SARS COVID-19 Main Protease Target from In-House, Chembridge and Zinc Databases by Structure-Based Virtual Screening, Molecular Docking and Molecular Dynamics Simulations by Ghufran, Mehreen, Ullah, Mehran, Khan, Haider Ali, Ghufran, Sabreen, Ayaz, Muhammad, Siddiq, Muhammad, Abbas, Syed Qamar, Hassan, Syed Shams Ul, Bungau, Simona

“…Pharmacological strategies to lower the viral load among patients suffering from severe diseases were researched in great detail during the SARS-CoV-2…”
Get full text

HPLC-DAD phenolics analysis, α-glucosidase, α-amylase inhibitory, molecular docking and nutritional profiles of Persicaria hydropiper L by Mahnashi, Mater H, Alqahtani, Yahya S, Alyami, Bandar A, Alqarni, Ali O, Alqahl, Sultan A, Ullah, Farhat, Sadiq, Abdul, Zeb, Alam, Ghufran, Mehreen, Kuraev, Alexey, Nawaz, Asif, Ayaz, Muhammad

“…Natural phenolic compounds and Phenolics-rich medicinal plants are also of great interest in the management of diabetes. The current study was aimed to analyze…”
Get full text

Exploration of organotin(IV) derivatives for medicinal applications: Synthesis, spectroscopic characterization, structural elucidation and molecular docking study by Sirajuddin, Muhammad, Ali, Saqib, McKee, Vickie, Wadood, Abdul, Ghufran, Mehreen

“…Organotin (IV) derivatives of carboxylate ligand, 4-(4-methoxyanilino)-4-oxobutanoic acid, have been synthesized and characterized by FTIR, NMR, CHN analysis,…”
Get full text

New Hybrid Hydrazinyl Thiazole Substituted Chromones: As Potential α-Amylase Inhibitors and Radical (DPPH & ABTS) Scavengers by Salar, Uzma, Khan, Khalid Mohammed, Chigurupati, Sridevi, Taha, Muhammad, Wadood, Abdul, Vijayabalan, Shantini, Ghufran, Mehreen, Perveen, Shahnaz

“…Current research is based on the identification of novel inhibitors of α -amylase enzyme. For that purpose, new hybrid molecules of hydrazinyl thiazole…”
Get full text

In-silico design of peptide inhibitors of K-Ras target in cancer disease by Ghufran, Mehreen, Rehman, Ashfaq Ur, Shah, Masaud, Ayaz, Muhammad, Ng, Ho Leung, Wadood, Abdul

“…Cancer is a leading cause of death, over one million individuals analyzed, and around 500,000 deaths happen due to cancer every year alone in the United…”
Get full text

In-silico evaluations of the isolated phytosterols from polygonum hydropiper L against BACE1 and MAO drug targets by Ayaz, Muhammad, Wadood, Abdul, Sadiq, Abdul, Ullah, Farhat, Anichkina, Olga, Ghufran, Mehreen

“…Our previous anti-Alzheimer's studies on crude extracts, essential oils and isolated compounds including β-sitostrol from Polygonum hydropiper L, motivated us…”
Get full text

Selective glycosidase inhibitors: A patent review (2012–present) by Wadood, Abdul, Ghufran, Mehreen, Khan, Ajmal, Azam, Syed Sikander, Jelani, Musharraf, Uddin, Reaz

“…In the recent decades, the interest on glycosidases has dramatically increased, mainly because these enzymes play a vital role in many biological processes…”
Get full text

Synthesis, in vitro alpha-glucosidase inhibitory potential of benzimidazole bearing bis-Schiff bases and their molecular docking study by Rahim, Fazal, Zaman, Khalid, Taha, Muhammad, Ullah, Hayat, Ghufran, Mehreen, Wadood, Abdul, Rehman, Wajid, Uddin, Nizam, Shah, Syed Adnan Ali, Sajid, Muhammad, Nawaz, Faisal, Khan, Khalid Mohammed

“…[Display omitted] •Synthesis of benzimidazole bearing bis Schiff base derivatives.•In vitro alpha-glucosidase activity.•Identification of a new class of…”
Get full text

New lead compounds identification against KRas mediated cancers through pharmacophore-based virtual screening and in vitro assays by Ghufran, Mehreen, Rehman, Ashfaq Ur, Ayaz, Muhammad, ul-Haq, Zaheer, Uddin, Reaz, Azam, Syed Sikander, Wadood, Abdul

“…Cancer remains the leading cause of mortality and morbidity in the world, with 19.3 million new diagnoses and 10.1 million deaths in 2020. Cancer is caused due…”
Get full text

Appraisal of the Neuroprotective Potentials of Isoeugenol Using In-vitro, In-vivo and In-silico Approaches by Alyami, Bandar A., Ahmad, Zeeshan, Ghufran, Mehreen, Mahnashi, Mater H., Sadiq, Abdul, Ayaz, Muhammad

“…Background: Alzheimer's disease (AD) is a neurodegenerative condition that affects the elder population and is linked to behavioral instability and cognitive…”
Get full text

Synthesis, characterization, biological screenings and molecular docking study of Organotin(IV) derivatives of 2,4-dichlorophenoxyacetic acid by Naz, Nida, Sirajuddin, Muhammad, Haider, Ali, Abbas, Syed Mustansar, Ali, Saqib, Wadood, Abdul, Ghufran, Mehreen, Rehman, Gauhar, Mirza, Bushra

“…New tri- and diorganotin (IV) derivatives of 2,4-dichlorophenoxyacetic acid with general formula: R3SnL and R2SnL2: {Me3SnL (1), Bu3SnL (2), Me2SnL2 (3),…”
Get full text

Dihydropyrimidones: As novel class of β-glucuronidase inhibitors by Ali, Farman, Khan, Khalid Mohammed, Salar, Uzma, Iqbal, Sarosh, Taha, Muhammad, Ismail, Nor Hadiani, Perveen, Shahnaz, Wadood, Abdul, Ghufran, Mehreen, Ali, Basharat

“…[Display omitted] •Dihydropyrimidones 1–37 were synthesized by ‘one pot’ three component reaction.•In vitro β-glucuronidase inhibitory activity were…”
Get full text

Synthesis, crystal structure, DNA binding and molecular docking studies of zinc(II) carboxylates by Muhammad, Niaz, Ikram, Muhammad, Wadood, Abdul, Rehman, Sadia, Shujah, Shaukat, Erum, Ghufran, Mehreen, Rahim, Shahnaz, Shah, Muzamil, Schulzke, Carola

“…New zinc(II) carboxylate complexes [Zn(3-F-C6H4CH2COO)2]n (1), [Zn3(3-F-C6H4CH2COO)6(Phen)2] (2) and [Zn3(3-F-C6H4CH2COO)6(bipy)2] (3) were synthesized and…”
Get full text

Synthesis, in vitro urease inhibitory activity and molecular docking of 3,5‐disubstituted thiadiazine‐2‐thiones by Shah, Muhammad Ishaq Ali, Khan, Rasool, Arfan, Mohammad, Wadood, Abdul, Ghufran, Mehreen

“…A series of 3,5‐disubstituted‐tetrahydro‐thiadiazine‐2‐thione (1‐16) have been synthesized, characterized by elemental analysis, infrared (IR), UV‐visible, 1H…”
Get full text

Synthesis, in vitro β-glucuronidase inhibitory potential and molecular docking studies of quinolines by Bano, Bilquees, Arshia, Khan, Khalid Mohammed, Kanwal, Fatima, Bibi, Taha, Muhammad, Ismail, Nor Hadiani, Wadood, Abdul, Ghufran, Mehreen, Perveen, Shahnaz

“…In this study synthesis and β-glucuronidase inhibitory potential of 3/5/8 sulfonamide and 8-sulfonate derivatives of quinoline (1–40) are discussed. Studies…”
Get full text

In Silico Strategies for Designing of Peptide Inhibitors of Oncogenic K-Ras G12V Mutant: Inhibiting Cancer Growth and Proliferation by Ghufran, Mehreen, Khan, Haider Ali, Ullah, Mehran, Ghufran, Sabreen, Ayaz, Muhammad, Siddiq, Muhammad, Hassan, Syed Shams Ul, Bungau, Simona

“…Ras plays a pivotal function in cell proliferation and is an important protein in signal transduction pathways. Mutations in genes encoding the Ras protein…”
Get full text