Search Results - "Ghribi, O"

Oxidative stress in blood in Alzheimer's disease and mild cognitive impairment: A meta-analysis by Schrag, M, Mueller, C, Zabel, M, Crofton, A, Kirsch, W.M, Ghribi, O, Squitti, R, Perry, G

“…Abstract Abnormal oxidative stress is an established feature of Alzheimer's disease, but clinical trials aiming to reduce oxidative stress have not yet proven…”
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Regional and Selective Effects of Oestradiol and Progesterone on NMDA and AMPA Receptors in the Rat Brain by Cyr, M, Ghribi, O, Di Paolo, T

“…We investigated the effect of 10 months ovariectomy and a correction therapy, 2 weeks before the rats were killed, of oestradiol, progesterone or their…”
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Cholinergic systems and long-term potentiation in memory-impaired apolipoprotein E-deficient mice by Krzywkowski, P., Ghribi, O., Gagné, J., Chabot, C., Kar, S., Rochford, J., Massicotte, G., Poirier, J.

“…Impairments in cholinergic neurotransmitter systems of the basal forebrain are a hallmark of Alzheimer's disease pathophysiology. The presence of the ε4 allele…”
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Potential mechanisms linking cholesterol to Alzheimer's disease-like pathology in rabbit brain, hippocampal organotypic slices, and skeletal muscle by Ghribi, Othman

“…Epidemiological, animal, and cellular studies suggest that abnormalities in cholesterol metabolism are important in the pathogenesis of Alzheimer's disease…”
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Elevated clozapine plasma concentrations after fluvoxamine initiation by DuMortier, G, Lochu, A, Colen de Melo, P, Ghribi, O, Roche-Rabreau, D, DeGrassat, K, Desce, J M

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Mechanisms of aluminum-induced neurodegeneration in animals: Implications for Alzheimer's disease by Savory, John, Herman, Mary M, Ghribi, Othman

“…For four decades the controversial question concerning a possible role for aluminum neurotoxicity in contributing to the pathogenesis of Alzheimer's disease…”
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Blockers of NMDA-operated channels decrease glutamate and aspartate extracellular accumulation in striatum during forebrain ischaemia in rats by Ghribi, O, Callebert, J, Verrecchia, C, Plotkine, M, Boulu, R G

“…Brain microdialysis was used to study changes in the glutamate and aspartate extracellular concentrations in the striatum of conscious rats submitted to 30…”
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Intracellular mechanisms underlying aluminum-induced apoptosis in rabbit brain by Savory, John, Herman, Mary M., Ghribi, Othman

“…Loss of neurons is a hallmark of neurodegenerative disorders and there is increasing evidence suggesting that apoptosis is a key mechanism by which neurons die…”
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Inhibition of glutamate release in rat hippocampus by kynurenic acid does not protect CA1 cells from forebrain ischemia by Lekieffre, D, Ghribi, O, Callebert, J, Allix, M, Plotkine, M, Boulu, R G

“…We assessed the effect of a broad spectrum glutamatergic receptor antagonist, kynurenic acid (500 mg/kg) on ischemia-induced hippocampal glutamate release and…”
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Targeted glycomics by selected reaction monitoring for highly sensitive glycan compositional analysis by Zhang, Hongquan, Wang, Zhaohui, Stupak, Jacek, Ghribi, Othman, Geiger, Jonathan D., Liu, Qing Yan, Li, Jianjun

“…The development of glycomics increasingly requires the detection and quantification of large numbers of glycans, which is only partially achieved by current…”
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Lithium inhibits Aβ-induced stress in endoplasmic reticulum of rabbit hippocampus but does not prevent oxidative damage and tau phosphorylation by Ghribi, Othman, Herman, Mary M., Savory, John

“…The goal of this study was to assess the in vivo effect of Aβ on apoptosis pathways involving the endoplasmic reticulum and mitochondria, and its relationship…”
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Lithium inhibits aluminum‐induced apoptosis in rabbit hippocampus, by preventing cytochrome c translocation, Bcl‐2 decrease, Bax elevation and caspase‐3 activation by Ghribi, Othman, Herman, Mary M., Spaulding, Natalie K., Savory, John

“…A variety of studies on neuronal death models suggest that lithium has neuroprotective properties. In the present investigation, we have examined the effect of…”
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MPP+ Induces the Endoplasmic Reticulum Stress Response in Rabbit Brain Involving Activation of the ATF-6 and NF-κB Signaling Pathways by GHRIBI, OTHMAN, HERMAN, MARY M, PRAMOONJAGO, PATCHARIN, SAVORY, JOHN

“…Inhibition of mitochondrial function and the subsequent generation of oxidative stress are strongly suggested to underlie MPTP/MPP-induced neurotoxicity, which…”
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GDNF Protects against Aluminum-Induced Apoptosis in Rabbits by Upregulating Bcl-2 and Bcl-XL and Inhibiting Mitochondrial Bax Translocation by Ghribi, Othman, Herman, Mary M., Forbes, Michael S., DeWitt, David A., Savory, John

“…Direct (intracisternal) injection of aluminum complexes into rabbit brain results in a number of similarities with the neuropathological and biochemical…”
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Alteration of glutamate receptors in the striatum of dyskinetic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkeys following dopamine agonist treatment by Calon, Frédéric, Morissette, Marc, Ghribi, Othman, Goulet, Martin, Grondin, Richard, Blanchet, Pierre J, Bédard, Paul J, DiPaolo, Thérèse

“…The effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced nigrostriatal lesion and dopaminomimetic treatment on parameters of glutamatergic…”
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Co-involvement of mitochondria and endoplasmic reticulum in regulation of apoptosis: changes in cytochrome c, Bcl-2 and Bax in the hippocampus of aluminum-treated rabbits by Ghribi, Othman, DeWitt, David A, Forbes, Michael S, Herman, Mary M, Savory, John

“…Neurodegenerative diseases, including Alzheimer’s disease, are characterized by a progressive and selective loss of neurons. Apoptosis under mitochondrial…”
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Ovarian steroids and selective estrogen receptor modulators activity on rat brain NMDA and AMPA receptors by Cyr, Michel, Ghribi, Othman, Thibault, Caroline, Morissette, Marc, Landry, Michelle, Di Paolo, Therese

“…Glutamate and glutamate receptors are well known to play a major excitatory role in the brain. Recent findings on ovarian steroids and selective estrogen…”
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The endoplasmic reticulum is the main site for caspase-3 activation following aluminum-induced neurotoxicity in rabbit hippocampus by GHRIBI, Othman, HERMAN, Mary M, SAVORY, John

“…We have assessed the distribution of caspase-3 in subcellular fractions from rabbit brain hippocampus and find that in controls the pro-caspase-3 form is…”
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Contrôle de qualité des monodoses de 7 principes actifs by FELDMAN, D, GHRIBI, O, OLIARY, J, DUMORTIER, G, DEGRASSAT, K, LEVERGE, R

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Aluminium and neuronal cell injury: inter-relationships between neurofilamentous arrays and apoptosis by Savory, John, Ghribi, Othman, Forbes, Michael S., Herman, Mary M.

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