Search Results - "Ghoshal, Kalpana"

miR-122 is a unique molecule with great potential in diagnosis, prognosis of liver disease, and therapy both as miRNA mimic and antimir by Thakral, Sharda, Ghoshal, Kalpana

“…miR-122, a completely conserved liver-specific miRNA in vertebrates, is essential for the maintenance of liver homeostasis. This 22 nucleotide RNA regulates…”
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Blocking the CCL2-CCR2 Axis Using CCL2-Neutralizing Antibody Is an Effective Therapy for Hepatocellular Cancer in a Mouse Model by Teng, Kun-Yu, Han, Jianfeng, Zhang, Xiaoli, Hsu, Shu-Hao, He, Shun, Wani, Nissar A, Barajas, Juan M, Snyder, Linda A, Frankel, Wendy L, Caligiuri, Michael A, Jacob, Samson T, Yu, Jianhua, Ghoshal, Kalpana

“…Hepatocellular carcinoma, a deadly disease, commonly arises in the setting of chronic inflammation. C-C motif chemokine ligand 2 (CCL2/MCP1), a chemokine that…”
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mRNA Destabilization Is the Dominant Effect of Mammalian MicroRNAs by the Time Substantial Repression Ensues by Eichhorn, Stephen W., Guo, Huili, McGeary, Sean E., Rodriguez-Mias, Ricard A., Shin, Chanseok, Baek, Daehyun, Hsu, Shu-hao, Ghoshal, Kalpana, Villén, Judit, Bartel, David P.

“…MicroRNAs (miRNAs) regulate target mRNAs through a combination of translational repression and mRNA destabilization, with mRNA destabilization dominating at…”
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MicroRNA-21 Regulates Expression of the PTEN Tumor Suppressor Gene in Human Hepatocellular Cancer by Meng, Fanyin, Henson, Roger, Wehbe–Janek, Hania, Ghoshal, Kalpana, Jacob, Samson T, Patel, Tushar

“…Background & Aims: microRNAs (miRNAs) are short noncoding RNAs that regulate gene expression negatively. Although a role for aberrant miRNA expression in…”
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Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver by Hsu, Shu-Hao, Wang, Bo, Kota, Janaiah, Yu, Jianhua, Costinean, Stefan, Kutay, Huban, Yu, Lianbo, Bai, Shoumei, La Perle, Krista, Chivukula, Raghu R, Mao, Hsiaoyin, Wei, Min, Clark, K Reed, Mendell, Jerry R, Caligiuri, Michael A, Jacob, Samson T, Mendell, Joshua T, Ghoshal, Kalpana

“…miR-122, an abundant liver-specific microRNA (miRNA), regulates cholesterol metabolism and promotes hepatitis C virus (HCV) replication. Reduced miR-122…”
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Stat3-mediated activation of microRNA-23a suppresses gluconeogenesis in hepatocellular carcinoma by down-regulating Glucose-6-phosphatase and peroxisome proliferator-activated receptor gamma, coactivator 1 alpha by Wang, Bo, Hsu, Shu-Hao, Frankel, Wendy, Ghoshal, Kalpana, Jacob, Samson T.

“…Considerable effort has been made in elucidating the mechanism and functional significance of high levels of aerobic glycolysis in cancer cells, commonly…”
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MicroRNA-122 Inhibits Tumorigenic Properties of Hepatocellular Carcinoma Cells and Sensitizes These Cells to Sorafenib by Bai, Shoumei, Nasser, Mohd W., Wang, Bo, Hsu, Shu-Hao, Datta, Jharna, Kutay, Huban, Yadav, Arti, Nuovo, Gerard, Kumar, Pawan, Ghoshal, Kalpana

“…MicroRNAs are negative regulators of protein coding genes. The liver-specific microRNA-122 (miR-122) is frequently suppressed in primary hepatocellular…”
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MicroRNA-221/222 Confers Tamoxifen Resistance in Breast Cancer by Targeting p27Kip1 by Miller, Tyler E., Ghoshal, Kalpana, Ramaswamy, Bhuvaneswari, Roy, Satavisha, Datta, Jharna, Shapiro, Charles L., Jacob, Samson, Majumder, Sarmila

“…We explored the role of microRNAs (miRNAs) in acquiring resistance to tamoxifen, a drug successfully used to treat women with estrogen receptor-positive breast…”
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The role of miR-122 in the dysregulation of glucose-6-phosphate dehydrogenase (G6PD) expression in hepatocellular cancer by Barajas, Juan M., Reyes, Ryan, Guerrero, Maria J., Jacob, Samson T., Motiwala, Tasneem, Ghoshal, Kalpana

“…Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide. Thus, a better understanding of molecular aberrations involved…”
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Cationic lipid nanoparticles for therapeutic delivery of siRNA and miRNA to murine liver tumor by Hsu, Shu-hao, PhD, Yu, Bo, PhD, Wang, Xinmei, PhD, Lu, Yuanzhi, PhD, Schmidt, Carl R., MD, Lee, Robert J., PhD, Lee, L. James, PhD, Jacob, Samson T., PhD, Ghoshal, Kalpana, PhD

“…Abstract miR-122, a liver-specific tumor suppressor microRNA, is frequently down-regulated in hepatocellular carcinoma (HCC). LNP-DP1, a cationic lipid…”
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Mouse models of acute and chronic hepacivirus infection by Billerbeck, Eva, Wolfisberg, Raphael, Fahnøe, Ulrik, Xiao, Jing W., Quirk, Corrine, Luna, Joseph M., Cullen, John M., Hartlage, Alex S., Chiriboga, Luis, Ghoshal, Kalpana, Lipkin, W. Ian, Bukh, Jens, Scheel, Troels K. H., Kapoor, Amit, Rice, Charles M.

“…An estimated 71 million people worldwide are infected with hepatitis C virus (HCV). The lack of small-animal models has impeded studies of antiviral immune…”
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Downregulation of miR-122 in the rodent and human hepatocellular carcinomas by Kutay, Huban, Bai, Shoumei, Datta, Jharna, Motiwala, Tasneem, Pogribny, Igor, Frankel, Wendy, Jacob, Samson T., Ghoshal, Kalpana

“…MicroRNAs (miRs) are conserved small non‐coding RNAs that negatively regulate gene expression. The miR profiles are markedly altered in cancers and some of…”
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ERK Activation Globally Downregulates miRNAs through Phosphorylating Exportin-5 by Sun, Hui-Lung, Cui, Ri, Zhou, JianKang, Teng, Kun-yu, Hsiao, Yung-Hsuan, Nakanishi, Kotaro, Fassan, Matteo, Luo, Zhenghua, Shi, Guqin, Tili, Esmerina, Kutay, Huban, Lovat, Francesca, Vicentini, Caterina, Huang, Han-Li, Wang, Shih-Wei, Kim, Taewan, Zanesi, Nicola, Jeon, Young-Jun, Lee, Tae Jin, Guh, Jih-Hwa, Hung, Mien-Chie, Ghoshal, Kalpana, Teng, Che-Ming, Peng, Yong, Croce, Carlo M.

“…MicroRNAs (miRNA) are mostly downregulated in cancer. However, the mechanism underlying this phenomenon and the precise consequence in tumorigenesis remain…”
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Role of microRNA‐155 at early stages of hepatocarcinogenesis induced by choline‐deficient and amino acid–defined diet in C57BL/6 mice by Wang, Bo, Majumder, Sarmila, Nuovo, Gerard, Kutay, Huban, Volinia, Stefano, Patel, Tushar, Schmittgen, Thomas D., Croce, Carlo, Ghoshal, Kalpana, Jacob, Samson T.

“…MicroRNAs (miRs) are conserved, small (20‐25 nucleotide) noncoding RNAs that negatively regulate expression of messenger RNAs (mRNAs) at the…”
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Reciprocal regulation of microRNA‐122 and c‐Myc in hepatocellular cancer: Role of E2F1 and transcription factor dimerization partner 2 by Wang, Bo, Hsu, Shu‐hao, Wang, Xinmei, Kutay, Huban, Bid, Hemant Kumar, Yu, Jianhua, Ganju, Ramesh K., Jacob, Samson T., Yuneva, Mariia, Ghoshal, Kalpana

“…c‐Myc is a well‐known oncogene frequently up‐regulated in different malignancies, whereas liver‐specific microRNA (miR)‐122, a bona fide tumor suppressor, is…”
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Extracellular mRNA detected by molecular beacons in tethered lipoplex nanoparticles for diagnosis of human hepatocellular carcinoma by Wang, Xinmei, Kwak, Kwang Joo, Yang, Zhaogang, Zhang, Aili, Zhang, Xiaoli, Sullivan, Rachael, Lin, Dan, Lee, Robert L, Castro, Carlos, Ghoshal, Kalpana, Schmidt, Carl, Lee, L James

“…Hepatocellular carcinoma (HCC) remains one of the major causes of cancer related deaths. Although ultrasonography (US), computed tomography (CT) and/or…”
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MicroRNA‐122 regulates polyploidization in the murine liver by Hsu, Shu‐hao, Delgado, Evan R., Otero, P. Anthony, Teng, Kun‐yu, Kutay, Huban, Meehan, Kolin M., Moroney, Justin B., Monga, Jappmann K., Hand, Nicholas J., Friedman, Joshua R., Ghoshal, Kalpana, Duncan, Andrew W.

“…A defining feature of the mammalian liver is polyploidy, a numerical change in the entire complement of chromosomes. The first step of polyploidization…”
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miRNA-122 Protects Mice and Human Hepatocytes from Acetaminophen Toxicity by Regulating Cytochrome P450 Family 1 Subfamily A Member 2 and Family 2 Subfamily E Member 1 Expression by Chowdhary, Vivek, Teng, Kun-yu, Thakral, Sharda, Zhang, Bo, Lin, Cho-hao, Wani, Nissar, Bruschweiler-Li, Lei, Zhang, Xiaoli, James, Laura, Yang, Dakai, Junge, Norman, Brüschweiler, Rafael, Lee, William M., Ghoshal, Kalpana

“…Acetaminophen toxicity is a leading cause of acute liver failure (ALF). We found that miRNA-122 (miR-122) is down-regulated in liver biopsy specimens of…”
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Lactosylated gramicidin-based lipid nanoparticles (Lac-GLN) for targeted delivery of anti-miR-155 to hepatocellular carcinoma by Zhang, Mengzi, Zhou, Xiaoju, Wang, Bo, Yung, Bryant C., Lee, Ly J., Ghoshal, Kalpana, Lee, Robert J.

“…Lactosylated gramicidin-containing lipid nanoparticles (Lac-GLN) were developed for delivery of anti-microRNA-155 (anti-miR-155) to hepatocellular carcinoma…”
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Enhanced hepatic delivery of siRNA and microRNA using oleic acid based lipid nanoparticle formulations by Wang, Xinmei, Yu, Bo, Ren, Wei, Mo, Xiaokui, Zhou, Chenguang, He, Hongyan, Jia, HuLiang, Wang, Lu, Jacob, Samson T., Lee, Robert J., Ghoshal, Kalpana, Lee, L. James

“…Many cationic lipids have been developed for lipid-based nanoparticles (LNPs) for delivery of siRNA and microRNA (miRNA). However, less attention has been paid…”
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