Search Results - "Ghosh, Supurna"

Upregulation of DJ-1 in Dopaminergic Neurons by a Physically-Modified Saline: Implications for Parkinson's Disease by Jana, Malabendu, Dasarathy, Sridevi, Ghosh, Supurna, Pahan, Kalipada

“…Parkinson's disease (PD) is the second most common neurodegenerative disorder in human and loss-of-functions DJ-1 mutations are associated with a familial form…”
Get full text

A physically-modified saline suppresses neuronal apoptosis, attenuates tau phosphorylation and protects memory in an animal model of Alzheimer's disease by Modi, Khushbu K, Jana, Arundhati, Ghosh, Supurna, Watson, Richard, Pahan, Kalipada

“…Alzheimer's disease (AD), the leading cause of dementia in the aging population, is characterized by the presence of neuritic plaques, neurofibrillary tangles…”
Get full text

Neuroprotective effect of the RNS60 in a mouse model of transient focal cerebral ischemia by Baena-Caldas, Gloria Patricia, Li, Jie, Pedraza, Lina, Ghosh, Supurna, Kalmes, Andreas, Barone, Frank C, Moreno, Herman, Hernández, A Iván

“…Stroke is a major cause of death, disability, and public health problems. Its intervention is limited to early treatment with thrombolytics and/or endovascular…”
Get full text

Protection of Tregs, suppression of Th1 and Th17 cells, and amelioration of experimental allergic encephalomyelitis by a physically-modified saline by Mondal, Susanta, Martinson, Jeffrey A, Ghosh, Supurna, Watson, Richard, Pahan, Kalipada

“…In multiple sclerosis (MS) and other autoimmune diseases, the autoreactive T cells overcome the resistance provided by the regulatory T cells (Tregs) due to a…”
Get full text

RNS60 exerts therapeutic effects in the SOD1 ALS mouse model through protective glia and peripheral nerve rescue by Vallarola, Antonio, Sironi, Francesca, Tortarolo, Massimo, Gatto, Noemi, De Gioia, Roberta, Pasetto, Laura, De Paola, Massimiliano, Mariani, Alessandro, Ghosh, Supurna, Watson, Richard, Kalmes, Andreas, Bonetto, Valentina, Bendotti, Caterina

“…Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects the motor neuromuscular system leading to complete paralysis and…”
Get full text

Engagement of collagen-binding integrins promotes matrix metalloproteinase-9-dependent e-cadherin ectodomain shedding in ovarian carcinoma cells by SYMOWICZ, Jaime, ADLEY, Brian P, GLEASON, Kara J, JOHNSON, Jeffrey J, GHOSH, Supurna, FISHMAN, David A, HUDSON, Laurie G, STACK, M. Sharon

“…Reversible modulation of cell-cell adhesion, cell-matrix adhesion, and proteolytic activity plays a critical role in remodeling of the neoplastic ovarian…”
Get full text

Correction: A Physically-Modified Saline Suppresses Neuronal Apoptosis, Attenuates Tau Phosphorylation and Protects Memory in an Animal Model of Alzheimer's Disease by Modi, Khushbu K, Jana, Arundhati, Ghosh, Supurna, Watson, Richard, Pahan, Kalipada

“…[This corrects the article DOI: 10.1371/journal.pone.0103606.]…”
Get full text

Enhancement of morphological plasticity in hippocampal neurons by a physically modified saline via phosphatidylinositol-3 kinase by Roy, Avik, Modi, Khushbu K, Khasnavis, Saurabh, Ghosh, Supurna, Watson, Richard, Pahan, Kalipada

“…Increase of the density of dendritic spines and enhancement of synaptic transmission through ionotropic glutamate receptors are important events, leading to…”
Get full text

A Phase I Assessment Of Safety and Tolerability Of RNS60, a Novel Therapeutic Containing Charge-Stabilized Nanostructures In Asthma by Ghosh, Supurna, PhD, Kalmes, Andreas, PhD, Mock, Jarrad, Sutherland, Jocelyn, Watson, Richard, MD

Get full text

Polypyrimidine Tract-binding Protein (PTB) Differentially Affects Malignancy in a Cell Line-dependent Manner by Wang, Chen, Norton, John T., Ghosh, Supurna, Kim, Julie, Fushimi, Kazuo, Wu, Jane Y., Stack, M. Sharon, Huang, Sui

“…RNA processing is altered during malignant transformation, and expression of the polypyrimidine tract-binding protein (PTB) is often increased in cancer cells…”
Get full text

Functional Relevance of Urinary-type Plasminogen Activator Receptor-α3β1 Integrin Association in Proteinase Regulatory Pathways by Ghosh, Supurna, Johnson, Jeff J., Sen, Ratna, Mukhopadhyay, Subhendu, Liu, Yueying, Zhang, Feng, Wei, Ying, Chapman, Harold A., Stack, M. Sharon

“…Squamous cell carcinoma of the oral cavity is characterized by persistent, disorganized expression of integrin α3β1 and enhanced production of urinary-type…”
Get full text

Proteinase Suppression by E-cadherin-mediated Cell-Cell Attachment in Premalignant Oral Keratinocytes by Munshi, Hidayatullah G., Ghosh, Supurna, Mukhopadhyay, Subhendu, Wu, Yi I., Sen, Ratna, Green, Kathleen J., Stack, M. Sharon

“…The expression and activity of epithelial proteinases is under stringent control to prevent aberrant hydrolysis of structural proteins and disruption of tissue…”
Get full text

RNS60, a physically-modified saline, inhibits glial activation, suppresses neuronal apoptosis and protects memory in a mouse model of traumatic brain injury by Rangasamy, Suresh B., Ghosh, Supurna, Pahan, Kalipada

“…Traumatic brain injury (TBI) is a serious health issue that causes long-term neurological disability, particularly in young adults, athletes and war veterans…”
Get full text

Proteolytic modification of laminins: Functional consequences by Ghosh, Supurna, Stack, M. Sharon

“…The laminin family contains a number of complex, multi‐domain proteins that participate in a large variety of biologic processes. Limited proteolysis has been…”
Get full text

Upregulation of Myelin Gene Expression by a Physically-Modified Saline via Phosphatidylinositol 3-Kinase-Mediated Activation of CREB: Implications for Multiple Sclerosis by Jana, Malabendu, Ghosh, Supurna, Pahan, Kalipada

“…An increase in central nervous system (CNS) remyelination and a decrease in CNS inflammation are important steps to halt the progression of multiple sclerosis…”
Get full text

Abstract WP259: Acute Stroke Neuroprotection With Intravenous Rns60 In The Cynomolgus Macaque by Nashed, Joseph, Harrison, Kathleen A, Chen, Yining, Ghosh, Supurna, Kalmes, Andreas, Cook, Douglas J

“…IntroductionRNS60 is an experimental therapy comprised of stable oxygenated nanobubbles in a sodium chloride solution with an oxygen content of 55+/-5 ppm…”
Get full text

Abstract TP219: Rns60 Brain Protection In Mouse Ischemic Stroke Mitigates Plasma Tau And Cortical Microvascular Perfusion by Baena-Caldas, Gloria P, Li, Jie, Ghosh, Supurna, Kalmes, Andreas A, Barone, Frank C, Moreno, Herman, Hernandez, A. Ivan

“…IntroductionRNS60 is 0.9% saline solution hypothesized to contain oxygen nanobubbles. Recently, we showed that 13 days of RNS60 treatment after transient…”
Get full text

Suppression of Nuclear Factor-κB Activation and Inflammation in Microglia by Physically Modified Saline by Khasnavis, Saurabh, Jana, Arundhati, Roy, Avik, Mazumder, Monalisa, Bhushan, Bharat, Wood, Tony, Ghosh, Supurna, Watson, Richard, Pahan, Kalipada

“…Chronic inflammation involving activated microglia and astroglia is becoming a hallmark of many human diseases, including neurodegenerative disorders. Although…”
Get full text

RESCUE: A Randomized, Blinded, Placebo-controlled, Parallel Group Study Design to Determine the Safety of RNS60 in Large Vessel Occlusion Stroke Patients Undergoing Endovascular Thrombectomy (P10-5.029) by Ghosh, Supurna, Dubow, Jordan, Sutherland, Jocelyn, Kalmes, Andreas, Baird, Grayson, Mock, Jarrad, Smith, Wendy, Cook, Douglas, Madsen, Tracy E., Jayaraman, Mahesh, Moldovan, Krisztina, Torabi, Radmehr, Ansari, Sameer, Favilla, Christopher, Chiu, David, Clark, Wayne, Liebeskind, David, McTaggart, Ryan A.

“…Abstract only…”
Get full text

Protection of Dopaminergic Neurons in a Mouse Model of Parkinson’s Disease by a Physically-Modified Saline Containing Charge-Stabilized Nanobubbles by Khasnavis, Saurabh, Roy, Avik, Ghosh, Supurna, Watson, Richard, Pahan, Kalipada

“…Neuroinflammation underlies the pathogenesis of various neurodegenerative disorders including Parkinson’s disease (PD). Despite intense investigations, no…”
Get full text