Search Results - "Ghosh, Prahlad C."

Purification and characterization of a novel and robust L-asparaginase having low-glutaminase activity from Bacillus licheniformis: in vitro evaluation of anti-cancerous properties by Mahajan, Richi V, Kumar, Vinod, Rajendran, Vinoth, Saran, Saurabh, Ghosh, Prahlad C, Saxena, Rajendra Kumar

“…L-asparaginase having low glutaminase has been a key therapeutic agent in the treatment of acute lymphpoblastic leukemia (A.L.L). In the present study, an…”
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Hydroxyethylamine Based Phthalimides as New Class of Plasmepsin Hits: Design, Synthesis and Antimalarial Evaluation by Singh, Anil K, Rathore, Sumit, Tang, Yan, Goldfarb, Nathan E, Dunn, Ben M, Rajendran, Vinoth, Ghosh, Prahlad C, Singh, Neelu, Latha, N, Singh, Brajendra K, Rawat, Manmeet, Rathi, Brijesh

“…A novel class of phthalimides functionalized with privileged scaffolds was designed, synthesized and evaluated as potential inhibitors of plasmepsin 2 (Ki:…”
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Design, synthesis and biological evaluation of functionalized phthalimides: A new class of antimalarials and inhibitors of falcipain-2, a major hemoglobinase of malaria parasite by Singh, Anil K., Rajendran, Vinoth, Pant, Akansha, Ghosh, Prahlad C., Singh, Neelu, Latha, N., Garg, Sandeep, Pandey, Kailash C., Singh, Brajendra K., Rathi, Brijesh

“…[Display omitted] Phthalimides functionalized with cyclic amines were synthesized, characterized and screened for their in vitro antimalarial efficacy against…”
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Synergistic blending of high-valued heterocycles inhibits growth of Plasmodium falciparum in culture and P. berghei infection in mouse model by Kumar, Prashant, Achieng, Angela O., Rajendran, Vinoth, Ghosh, Prahlad C., Singh, Brajendra K., Rawat, Manmeet, Perkins, Douglas J., Kempaiah, Prakasha, Rathi, Brijesh

“…A series of phthalimide analogues, novelized with high-valued bioactive scaffolds was synthesized by means of click-chemistry under non-conventional microwave…”
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Cellular iron homeostasis and therapeutic implications of iron chelators in cancer by Raza, Mohsin, Chakraborty, Sankalpa, Choudhury, Monjoy, Ghosh, Prahlad C, Nag, Alo

“…Iron metabolism and homeostasis are imperative for the maintenance of normal physiological activities due to the element's critical involvement in a wide…”
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Mechanistic insights into a novel exporter-importer system of Mycobacterium tuberculosis unravel its role in trafficking of iron by Farhana, Aisha, Kumar, Sandeep, Rathore, Shailendra S, Ghosh, Prahlad C, Ehtesham, Nasreen Z, Tyagi, Anil K, Hasnain, Seyed E

“…Elucidation of the basic mechanistic and biochemical principles underlying siderophore mediated iron uptake in mycobacteria is crucial for targeting this…”
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Enhanced efficacy of anti-miR-191 delivery through stearylamine liposome formulation for the treatment of breast cancer cells by Sharma, Shivani, Rajendran, Vinoth, Kulshreshtha, Ritu, Ghosh, Prahlad C.

“…[Display omitted] MicroRNAs are gaining rapid attention as promising targets for cancer treatment; however, efficient delivery of therapeutic miRNA or…”
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P53-miR-191- SOX4 regulatory loop affects apoptosis in breast cancer by Sharma, Shivani, Nagpal, Neha, Ghosh, Prahlad C, Kulshreshtha, Ritu

“…miRNAs have emerged as key participants of p53 signaling pathways because they regulate or are regulated by p53. Here, we provide the first study demonstrating…”
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Synthesis and Characterization of Nano Selenium Using Plant Biomolecules and Their Potential Applications by Alam, Hammad, Khatoon, Nafeesa, Raza, Mohsin, Ghosh, Prahlad C., Sardar, Meryam

“…The present study reports the eco-friendly synthesis of selenium nanoparticles (SeNps) and their characterization. Synthesis of SeNps was carried out by…”
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Enhanced anti-malarial efficacy of mefloquine delivered via cationic liposome in a murine model of experimental cerebral malaria by Raza, Mohsin, Bharti, Hina, Chauhan, Charu, Singal, Aakriti, Jha, Deepa, Ghosh, Prahlad C., Nag, Alo

“…[Display omitted] Malaria is a longstanding global health challenge that continues to afflict over 90 countries located in tropical and subtropical regions of…”
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Stearylamine Liposomal Delivery of Monensin in Combination with Free Artemisinin Eliminates Blood Stages of Plasmodium falciparum in Culture and P. berghei Infection in Murine Malaria by Rajendran, Vinoth, Rohra, Shilpa, Raza, Mohsin, Hasan, Gulam Mustafa, Dutt, Suparna, Ghosh, Prahlad C

“…The global emergence of drug resistance in malaria is impeding the therapeutic efficacy of existing antimalarial drugs. Therefore, there is a critical need to…”
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Long circulatory liposomal maduramicin inhibits the growth of Plasmodium falciparum blood stages in culture and cures murine models of experimental malaria by Raza, Mohsin, Bharti, Hina, Singal, Aakriti, Nag, Alo, Ghosh, Prahlad C

“…Malaria continues to be one of the deadliest infectious diseases and a global health menace. The emergence and spread of drug-resistant strains of malaria…”
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Potential therapeutic applications of plant toxin-ricin in cancer: challenges and advances by Tyagi, Nikhil, Tyagi, Monika, Pachauri, Manendra, Ghosh, Prahlad C.

“…Cancer is one of the most common devastating disease affecting millions of people per year worldwide. To fight against cancer, a number of natural plant…”
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Cell mediated immune response after challenge in Omp25 liposome immunized mice contributes to protection against virulent Brucella abortus 544 by Goel, Divya, Rajendran, Vinoth, Ghosh, Prahlad C, Bhatnagar, Rakesh

“…Highlights ► rOmp25 was encapsulated in egg PC–PE liposomes and PLGA microparticles. ► Single dose and booster dose regimen was assessed for liposomes and…”
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Synthesis, characterization, and antiplasmodial efficacy of sulfonamide‐appended [1,2,3]‐triazoles by Batra, Neha, Rajendran, Vinoth, Wadi, Ishan, Lathwal, Ankit, Dutta, Roshan Kumar, Ghosh, Prahlad C., Gupta, Rinkoo D., Nath, Mahendra

“…A series of benzenesulfonamide‐appended [1,2,3]‐triazole hybrids was synthesized by using [3 + 2] cycloaddition of primary, secondary, and tertiary sulfonamide…”
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Improved efficacy of doxycycline in liposomes against Plasmodium falciparum in culture and Plasmodium berghei infection in mice by Rajendran, Vinoth, Singh, Chanchal, Ghosh, Prahlad C

“…The rate at which Plasmodium falciparum is developing resistance to clinically used antimalarial drugs is alarming. Therefore, there is a compelling need to…”
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Folate receptor mediated targeted delivery of ricin entrapped into sterically stabilized liposomes to human epidermoid carcinoma (KB) cells: Effect of monensin intercalated into folate-tagged liposomes by Tyagi, Nikhil, Ghosh, Prahlad C.

“…The effect of folate on the surface of liposomes on the cytotoxicity of ricin entrapped into liposomes in combination with monensin intercalated into folate…”
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Author Correction: Synergistic blending of high-valued heterocycles inhibits growth of Plasmodium falciparum in culture and P. berghei infection in mouse model by Kumar, Prashant, Achieng, Angela O., Rajendran, Vinoth, Ghosh, Prahlad C., Singh, Brajendra K., Rawat, Manmeet, Perkins, Douglas J., Kempaiah, Prakasha, Rathi, Brijesh

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Synthesis and Evaluation of Antiplasmodial Activity of 2,2,2-Trifluoroethoxychalcones and 2-Fluoroethoxy Chalcones against Plasmodium falciparum in Culture by Devi, Kavita, Rajendran, Vinoth, Rangarajan, T M, Singh, Rishi Pal, Ghosh, Prahlad C, Singh, Manjula

“…A new class of compounds comprising two series of chalcones with 2,2,2-trifluoroethoxy group and 2-fluoroethoxy groups were synthesized and screened for in…”
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Identification of Mycobacterium tuberculosis BioA inhibitors by using structure-based virtual screening by Singh, Swati, Khare, Garima, Bahal, Ritika Kar, Ghosh, Prahlad C, Tyagi, Anil K

“…7,8-Diaminopelargonic acid synthase (BioA), an enzyme of biotin biosynthesis pathway, is a well-known promising target for anti-tubercular drug development. In…”
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