Search Results - "Ghosh, Deepraj"

Ovarian Cancer Exosomes Trigger Differential Biophysical Response in Tumor-Derived Fibroblasts by Lee, Amy H., Ghosh, Deepraj, Quach, Nhat, Schroeder, Devin, Dawson, Michelle R.

“…Exosomes are cell-secreted microvesicles that play important roles in epithelial ovarian cancer (EOC) progression, as they are constantly secreted into ascites…”
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Nuclear Membrane-Targeted Gold Nanoparticles Inhibit Cancer Cell Migration and Invasion by Ali, Moustafa R. K, Wu, Yue, Ghosh, Deepraj, Do, Brian H, Chen, Kuangcai, Dawson, Michelle R, Fang, Ning, Sulchek, Todd A, El-Sayed, Mostafa A

“…Most cancer patients die from metastasis. Recent studies have shown that gold nanoparticles (AuNPs) can slow down the migration/invasion speed of cancer cells…”
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Dysregulation in Actin Cytoskeletal Organization Drives Increased Stiffness and Migratory Persistence in Polyploidal Giant Cancer Cells by Xuan, Botai, Ghosh, Deepraj, Cheney, Emily M., Clifton, Elizabeth M., Dawson, Michelle R.

“…Polyploidal giant cancer cells (PGCCs) have been observed by pathologists in patient tumor samples and are especially prominent in late stage, high grade…”
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Metronomic and single high-dose paclitaxel treatments produce distinct heterogenous chemoresistant cancer cell populations by Mejia Peña, Carolina, Skipper, Thomas A., Hsu, Jeffrey, Schechter, Ilexa, Ghosh, Deepraj, Dawson, Michelle R.

“…More than 75% of epithelial ovarian cancer (EOC) patients experience disease recurrence after initial treatment, highlighting our incomplete understanding of…”
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Differential mechanical response of mesenchymal stem cells and fibroblasts to tumor-secreted soluble factors by McGrail, Daniel J, Ghosh, Deepraj, Quach, Nhat D, Dawson, Michelle R

“…The progression of neoplastic malignancies is a complex process resulting not only from the accumulation of mutations within tumor cells, but also modulation…”
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Fibroblast senescence-associated extracellular matrix promotes heterogeneous lung niche by Howes, Andrew M., Dea, Nova C., Ghosh, Deepraj, Krishna, Krishangi, Wang, Yihong, Li, Yanxi, Morrison, Braxton, Toussaint, Kimani C., Dawson, Michelle R.

“…Senescent cell accumulation in the pulmonary niche is associated with heightened susceptibility to age-related disease, tissue alterations, and ultimately a…”
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Senescence‐Associated Exosome Exchange Activates Myofibroblast Phenotype in Mesenchymal Stem Cells by Lee, Amy, Ghosh, Deepraj, Dawson, Michelle

“…Introduction Bone marrow derived mesenchymal stem cells (MSCs) are recruited and accumulate in primary tumors due to their natural tropism for inflammatory…”
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Contributions of the distinct biophysical phenotype of polyploidal giant cancer cells to cancer progression by Xuan, Botai, Ghosh, Deepraj, Dawson, Michelle R.

“…Polyploid giant cancer cells (PGCCs) are a commonly observed histological feature of human tumors and are particularly prominent in late stage and drug…”
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Vimentin filaments drive migratory persistence in polyploidal cancer cells by Xuan, Botai, Ghosh, Deepraj, Jiang, Joy, Shao, Rachelle, Dawson, Michelle R.

“…Polyploidal giant cancer cells (PGCCs) are multinucleated chemoresistant cancer cells found in heterogeneous solid tumors. Due in part to their apparent…”
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Abstract A002: Physical and metabolic aspects of therapy induced senescence and polyploidy in an evolving tumor microenvironment by Dawson, Michelle R., Ghosh, Deepraj

“…Abstract This abstract is being presented as a short talk in the scientific program. A full abstract is available in the Short Talks from Proffered Abstracts…”
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Abstract PR007: Physical and metabolic aspects of therapy induced senescence and polyploidy in an evolving tumor microenvironment by Dawson, Michelle R., Ghosh, Deepraj

“…Abstract Radiation and chemotherapy are highly effective at killing cancer cells but cells that survive treatment often develop therapy-induced senescence…”
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Abstract 1315: Biophysics of polyploidal cancer cells in an aging stroma by Dawson, Michelle, Xuan, Botai, Ghosh, Deepraj

“…Abstract Senescence is a potent tumor-suppressive mechanism that irreversibly arrests the growth of damaged cells. However, senescent cells that accumulate in…”
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Mechanosensitivity Analysis of Breast Cancer Tumor Cells from Needle Biopsy by Bedoya, Santiago Acero, Ghosh, Deepraj, Dawson, Michelle

“…Tumor stiffness has been associated with malignancy and increased risk for metastasis. Extensive research has been done investigating breast cancer cell lines'…”
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Development of a Novel 3D Model to Investigate the Role of Heterogeneity in Ovarian Cancer Chemoresistance by Mejia Peña, Carolina, Skipper, Thomas, Hsu, Jeffrey, Schechter, Ilexa, Ghosh, Deepraj, Dawson, Michelle

“…More than 70% of all patients diagnosed with epithelial ovarian cancer (EOC) succumb to their disease making EOC the most lethal gynecological cancer. The…”
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Senescence-associated exosomes transfer miRNA-induced fibrosis to neighboring cells by Lee, Amy H, Ghosh, Deepraj, Koh, Ivy L, Dawson, Michelle R

“…Radiation-induced fibrosis is a common side effect of radiotherapy, which is the most common treatment for cancer. However, radiation also causes p53-mediated…”
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Senescent mesenchymal stem cells remodel extracellular matrix driving breast cancer cells to a more-invasive phenotype by Ghosh, Deepraj, Mejia Pena, Carolina, Quach, Nhat, Xuan, Botai, Lee, Amy H, Dawson, Michelle R

“…Mesenchymal stem cells (MSCs) are essential for the regenerative process; however, biological aging and environmental stress can induce senescence - an…”
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Force balancing ACT-IN the tumor microenvironment: Cytoskeletal modifications in cancer and stromal cells to promote malignancy by Dawson, Michelle R, Xuan, Botai, Hsu, Jeffrey, Ghosh, Deepraj

“…The tumor microenvironment is a complex milieu that dictates the growth, invasion, and metastasis of cancer cells. Both cancer and stromal cells in the tumor…”
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Spatial Heterogeneity in Cytoskeletal Mechanics Response to TGF-β1 and Hypoxia Mediates Partial Epithelial-to-Mesenchymal Transition in Epithelial Ovarian Cancer Cells by Ghosh, Deepraj, Hsu, Jeffrey, Soriano, Kylen, Peña, Carolina, Lee, Amy, Dizon, Don, Dawson, Michelle

“…Metastatic progression of epithelial ovarian cancer (EOC) involves the partial epithelial-to-mesenchymal transition (EMT) of cancer cells in the primary tumor…”
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3D Spheroid Model of Fibroid Growth: Quantifying the Effect of Mechanical Environment Stiffness on Development [11E] by Gupta, Shabnam, Ghosh, Deepraj, Schutte, Stacey, Dawson, Michelle

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Microenvironment Influences Cancer Cell Mechanics from Tumor Growth to Metastasis by Ghosh, Deepraj, Dawson, Michelle R

“…The microenvironment in a solid tumor includes a multitude of cell types, matrix proteins, and growth factors that profoundly influence cancer cell mechanics…”
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