Search Results - "Ghosez, Leon"

A lifetime journey into the world of chemistry by Ghosez, Léon

“…The professional life of the author has been a fascinating journey through the magnificent landscapes of synthetic organic chemistry. A friendly editor invited…”
Get full text

Synthesis: Science or Technology?» A Few Comments from an Old‐timer by Ghosez, Léon

“…This short commentary adresses some problems associated with the present status and the future of research in organic synthesis. It simply reflects the…”
Get full text

A mild method for the replacement of a hydroxyl group by halogen: 3. the dichotomous behavior of α-haloenamines towards allylic and propargylic alcohols by Munyemana, François, Patiny, Luc, Ghosez, Léon

“…A study of the deoxyhalogenation of allylic and propargylic alcohols with tetramethyl-α-halo-enamines is reported. Primary allylic and primary and secondary…”
Get full text

Computational Exploration of Anomalous Regioselectivities in Cycloadditions of Ketenes to Oxazolines by Zhu, Ledong, Maskeri, Mark A, Ramirez, Melissa, Le Bideau, F, Ghosez, Léon, Houk, K. N

“…Thermal (2 + 2) cycloadditions of several N-carboalkoxy (R)-2-tert-butyldihydrooxazoles with ketenes have been studied experimentally by the Ghosez group…”
Get full text

Brönsted acid-catalyzed synthesis of diarylmethanes under non-genotoxic conditions by Mendoza, Oscar, Rossey, Guy, Ghosez, Léon

“…Triflic acid and triflimide were found to efficiently catalyze the formation of a wide diversity of diarylmethanes from the non-genotoxic benzylic acetates and…”
Get full text

A mild method for the replacement of a hydroxyl group by halogen: 2. unified procedure and stereochemical studies by Gati, Wafa, Munyemana, François, Colens, Alain, Srour, Aladdin, Dufour, Mathilde, Vardhan Reddy, K. Harsha, Téchy, Brigitte, Rosse, Gérard, Schweiger, Ed, Qiao, Qi, Ghosez, Léon

“…N,N-Dimethyl- and N,N-diisopropyl-1-halo-2-methyl-l-propenylamines are readily available reagents for the mild deoxyhalogenation of alcohols and hydroxyacids…”
Get full text

Design and synthesis of spirocyclic ligands of glucocorticoid receptors by Badarau, Eduard, Robert, Frédéric, Massip, Stéphane, Jakob, Florian, Lucas, Simon, Frormann, Sven, Ghosez, Léon

“…Spirocyclic indazoles were designed as potential ligands for the glucocorticoid receptors (GRs). A short and efficient synthetic sequence was developed…”
Get full text

Productive Syntheses of Privileged Scaffolds Inspired by the Recognition of a Diels–Alder Pattern Common to Three Classes of Natural Products by Badarau, Eduard, Reddy, K. Harsha Vardhan, Loudet, Aurore, Simon, Charles, Trembleau, Laurent, Claerhout, Stijn, Pair, Etienne, Massip, Stéphane, Breton, Philippe, Lesur, Brigitte, Goldstein, Solo, Fourquez, Jean‐Marie, Henlin, Jean Michel, Ghosez, Léon

“…Identification of a common Diels–Alder pattern in three classes of bioactive natural products led us to study the synthesis and cycloaddition of a new class of…”
Get full text

A mild method for the replacement of a hydroxyl group by halogen. 1. Scope and chemoselectivity by Munyemana, François, George, Isabelle, Devos, Alain, Colens, Alain, Badarau, Eduard, Frisque-Hesbain, Anne-Marie, Loudet, Aurore, Differding, Edmond, Damien, Jean-Marie, Rémion, Jeanine, Van Uytbergen, Jacqueline, Ghosez, Léon

“…α-Chloro-, bromo- and iodoenamines, which are readily prepared from the corresponding isobutyramides have been found to be excellent reagents for the…”
Get full text

Multicomponent Reactions for the Synthesis of Complex Piperidine Scaffolds by Zhu, Wei, Mena, Marisa, Jnoff, Eric, Sun, Na, Pasau, Patrick, Ghosez, Léon

“…Creating diversity: Multicomponent reactions for the synthesis of complex piperidine scaffolds lead to high levels of skeletal, functional, and stereochemical…”
Get full text

Discovery of a subnanomolar and selective spirocyclic agonist of the glucocorticoid receptor by Badarau, Eduard, Robert, Frédéric, Massip, Stéphane, Jakob, Florian, Lucas, Simon, Friebe, Daniela, Hennen, Stephanie, Frormann, Sven, Ghosez, Léon

“…Pure diastereomeric spirocyclic analogs of fluorocortivazol were conveniently prepared by a short and efficient synthetic sequence recently developed in our…”
Get full text

Trialkylsilyl triflimides as easily tunable organocatalysts for allylation and benzylation of silyl carbon nucleophiles with non-genotoxic reagents by Mendoza, Oscar, Rossey, Guy, Ghosez, Léon

“…Trialkylsilyl triflimides generated in situ are unique catalysts for the electrophilic benzylation or allylation of trialkylsilylenol ethers or allyl…”
Get full text

Functionalization of C60 via organometallic reagents by Champeil, Elise, Crean, Conor, Larraya, Carlos, Pescitelli, Gennaro, Proni, Gloria, Ghosez, Léon

“…The reaction of [60]fullerene with organolithium and Grignard reagents carrying orthoester, acetal or other end groups yielded adducts 3– 5 at the 6–6 bond of…”
Get full text

Synthesis of Enantiopure α-Chlorocyclobutanones and Cyclobutanols as Scaffolds for the Diverted Synthesis of Serine Protease Inhibitors by Yang, Gaoqiang, Ghosez, Léon

“…Synthetic paths towards highly functionalized α‐chlorocyclobutanone scaffolds susceptible to lead to serine proteases inhibitors were explored. The syntheses…”
Get full text

Study of the oxidation of 3-hydroxypyrroloindoles to pyrrolobenzoxazine alkaloids by Commandeur, Claude, Commandeur, Malgorzata, Bathany, Kathell, Kauffmann, Brice, Edmunds, Andrew J.F., Maienfisch, Peter, Ghosez, Léon

“…This report describes a detailed study of the oxidation-Meisenheimer rearrangement of N-methyl-3-hydroxy-7-chloropyrroloindoline ethyl ester and the…”
Get full text

Studies related to the total synthesis of the sesquiterpene core of the pyrrolobenzoxazine natural products CJ-12662 and CJ-12663 by Commandeur, Małgorzata, Commandeur, Claude, Paolis, Michael De, Edmunds, Andrew J.F., Maienfisch, Peter, Ghosez, Léon

“…A highly effective procedure is reported to synthesize a substituted bicyclo[4.2.0]octenol derivative by regioselective cycloaddition of phenyl-1-propynyl…”
Get full text

The search for tolerant Lewis acid catalysts. Part 2: Enantiopure cycloalkyldialkylsilyl triflimide catalysts by Tang, Zilong, Mathieu, Benoit, Tinant, Bernard, Dive, Georges, Ghosez, Léon

“…A series of 2-aryl- and arylmethyl-3-dialkylphenylsilyl cycloalkanones have been prepared and resolved. The pure enantiomers were reduced to the corresponding…”
Get full text

Acid promoted enantioselective oxygen-atom transfer from N-alkyl binaphthyl-derived oxaziridines onto sulfides by Akhatou, Abdeslam, Rahimi, Maryam, Cheboub, Karima, Ghosez, Léon, Hanquet, Gilles

“…Acid-promoted asymmetric sulfoxidations of prochiral sulfides using binaphthyl-derived oxaziridines have been studied. The reactions of dialkyl or aryl-alkyl…”
Get full text

Mechanisms and Conformational Control of (4 + 2) and (2 + 2) Cycloadditions of Dienes to Keteniminium Cations by Ramirez, Melissa, Li, Wenfei, Lam, Yu-hong, Ghosez, Léon, Houk, K. N

“…Selectivities in (4 + 2) and (2 + 2) cycloadditions of keteniminium cations with 1,3-dienes studied experimentally by Ghosez et al. were explored with ωB97X-D…”
Get full text

Selective targeting of synthetic antioxidants to mitochondria: towards a mitochondrial medicine for neurodegenerative diseases? by Dessolin, Jean, Schuler, Marie, Quinart, Alice, De Giorgi, Francesca, Ghosez, Leon, Ichas, François

“…Mitochondria are the major source of superoxide, and are responsible for activating apoptosis and oxidative damage during acute neuronal cell death and…”
Get full text